N-(2-hydroxy-4,5-dimethoxyphenyl)-(S)-alpha-malamic acid - Compound Card

N-(2-hydroxy-4,5-dimethoxyphenyl)-(S)-alpha-malamic acid

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N-(2-hydroxy-4,5-dimethoxyphenyl)-(S)-alpha-malamic acid

Structure
Zoomed Structure
  • Family: Acanthaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles COc1cc(NC(=O)[C@H](CC(=O)O)O)c(cc1OC)O
InChI InChI=1S/C12H15NO7/c1-19-9-3-6(7(14)4-10(9)20-2)13-12(18)8(15)5-11(16)17/h3-4,8,14-15H,5H2,1-2H3,(H,13,18)(H,16,17)/t8-/m0/s1
InChIKey IBOBTFXQPXYKOL-QMMMGPOBSA-N
Formula C12H15NO7
HBA 6
HBD 4
MW 285.25
Rotatable Bonds 6
TPSA 125.32
LogP 0.18
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.33
Exact Mass 285.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Justicia ghiesbreghtiana Acanthaceae Plantae 141992

Showing of synonyms

  • Ismail LD, Lorenz P and Stermitz FR. (1998). Isolation and synthesis of an alpha-malamic acid derivative from Justicia ghiesbreghtiana. Journal of Natural Products,1998,61(9),1174-1176. [View] [PubMed]
Pubchem: 10755532
Nmrshiftdb2: 70083927

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.74
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.030
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-4.68

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.380
Plasma Protein Binding
32.1
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.260
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.190
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.630
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
3.920
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.150
Rat (Acute)
1.890
Rat (Chronic Oral)
2.810
Fathead Minnow
3.840
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
415.570
Hydration Free Energy
-8.090
Log(D) at pH=7.4
-1.810
Log(P)
-0.49
Log S
-1.7
Log(Vapor Pressure)
-10.04
Melting Point
169.56
pKa Acid
4.05
pKa Basic
5.2
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9617
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9617
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9585
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9585
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9562
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9562
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9534
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9534
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.9439
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.9439
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9382
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9382
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9357
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9357
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9340
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9340
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9248
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9248
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.9166
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.9166
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 3 0.9163
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 3 0.9163
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.9128
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.9128
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9061
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9061
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8994
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8994
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8991
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8991
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8978
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8978
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8970
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8970
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.8917
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.8917
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8825
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8825
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8771
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8771
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8738
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8738
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8732
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8732
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8721
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8721
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 4 0.8714
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 4 0.8714
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8640
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8640
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8621
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8621
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 3 0.8619
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 3 0.8619
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 3 0.8599
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 3 0.8599
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8591
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8591
Acetylornithine/succinyldiaminopimelate aminotransferase P40732 ARGD_SALTY Salmonella typhimurium 3 0.8531
Acetylornithine/succinyldiaminopimelate aminotransferase P40732 ARGD_SALTY Salmonella typhimurium 3 0.8531
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 3 0.8458
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 3 0.8458
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 3 0.8427
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 3 0.8427
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.8418
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.8418
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8392
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8392
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.8380
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.8380
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8350
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8350
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.8265
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.8265
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 3 0.8242
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 3 0.8242
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8235
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8235
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.8220
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.8220
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8199
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8199
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8197
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8197
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8194
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8194
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8191
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8191
Ficolin-2 Q15485 FCN2_HUMAN Homo sapiens 3 0.8168
Ficolin-2 Q15485 FCN2_HUMAN Homo sapiens 3 0.8168
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8157
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8157
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8103
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8103
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 3 0.8071
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 3 0.8071
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8068
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8068
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.8054
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.8054
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8047
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8047
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8039
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8039
Predicted acetyltransferase Q97ML2 Q97ML2_CLOAB Clostridium acetobutylicum 3 0.8034
Predicted acetyltransferase Q97ML2 Q97ML2_CLOAB Clostridium acetobutylicum 3 0.8034
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8008
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8008
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7983
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7983
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7932
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7932
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7921
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7921
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7906
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7906
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7886
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7886
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7868
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7868
Actin, alpha skeletal muscle P68135 ACTS_RABIT Oryctolagus cuniculus 3 0.7854
Actin, alpha skeletal muscle P68135 ACTS_RABIT Oryctolagus cuniculus 3 0.7854
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7853
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7853
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7853
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7853
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7852
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7852
Cytosolic IMP-GMP specific 5'-nucleotidase Q5ZZB6 Q5ZZB6_LEGPH Legionella pneumophila subsp. pneumophila 4 0.7812
Cytosolic IMP-GMP specific 5'-nucleotidase Q5ZZB6 Q5ZZB6_LEGPH Legionella pneumophila subsp. pneumophila 4 0.7812
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7796
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7796
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 3 0.7774
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 3 0.7774
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7750
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7750
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7747
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7747
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 3 0.7699
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 3 0.7699
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7656
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7656
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7647
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7647
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7645
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7645
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 3 0.7609
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 3 0.7609
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7603
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7603
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7602
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7602
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 3 0.7601
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 3 0.7601
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7587
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7587
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7583
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7583
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7573
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7573
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7572
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7572
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7569
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7569
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 3 0.7561
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 3 0.7561
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7541
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7541
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P12995 BIOA_ECOLI Escherichia coli 3 0.7539
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P12995 BIOA_ECOLI Escherichia coli 3 0.7539
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7529
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7529
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7518
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7518
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.7516
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7516
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7516
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.7516
2-dehydro-3-deoxyphosphooctonate aldolase P0A715 KDSA_ECOLI Escherichia coli 3 0.7512
2-dehydro-3-deoxyphosphooctonate aldolase P0A715 KDSA_ECOLI Escherichia coli 3 0.7512
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7489
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7489
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7488
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7488
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7478
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7478
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7472
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7472
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7470
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7470
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7455
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7455
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7446
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7446
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7442
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7442
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7441
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7441
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 5 0.7435
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 5 0.7435
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7434
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7434
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7430
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7430
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7425
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7425
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7423
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7423
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7419
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7419
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7418
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7418
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7418
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7418
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7410
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7410
Tryptophan synthase alpha chain P16608 TRPA_THET2 Thermus thermophilus 3 0.7385
Tryptophan synthase alpha chain P16608 TRPA_THET2 Thermus thermophilus 3 0.7385
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7380
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7380
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7365
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7365
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7356
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7356
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7350
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7350
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7350
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7350
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7340
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7340
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7340
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7340
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 5 0.7337
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 5 0.7337
Biphenyl dioxygenase ferredoxin reductase subunit E7FJB9 E7FJB9_9BURK Acidovorax sp. KKS102 3 0.7336
Biphenyl dioxygenase ferredoxin reductase subunit E7FJB9 E7FJB9_9BURK Acidovorax sp. KKS102 3 0.7336
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7335
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7335
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7322
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7322
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.7314
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7314
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.7314
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7314
Lipoprotein E P26093 HEL_HAEIN Haemophilus influenzae 3 0.7310
Lipoprotein E P26093 HEL_HAEIN Haemophilus influenzae 3 0.7310
MutT/nudix family protein O33199 O33199_MYCTO Mycobacterium tuberculosis 3 0.7309
MutT/nudix family protein O33199 O33199_MYCTO Mycobacterium tuberculosis 3 0.7309
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7306
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7306
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7305
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7305
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7304
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7304
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7292
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7292
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7288
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7288
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7278
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7278
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7278
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7278
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7274
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7274
GMP synthase [glutamine-hydrolyzing] Q8IJR9 Q8IJR9_PLAF7 Plasmodium falciparum 4 0.7271
GMP synthase [glutamine-hydrolyzing] Q8IJR9 Q8IJR9_PLAF7 Plasmodium falciparum 4 0.7271
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7269
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7269
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7268
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7268
Polymerase basic protein 2 Q2LG68 Q2LG68_9INFA Influenza A virus) 4 0.7266
Polymerase basic protein 2 Q2LG68 Q2LG68_9INFA Influenza A virus) 4 0.7266
Deoxycytidylate deaminase H6WFU3 H6WFU3_9CAUD Cyanophage S-TIM5 4 0.7264
Deoxycytidylate deaminase H6WFU3 H6WFU3_9CAUD Cyanophage S-TIM5 4 0.7264
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7260
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7260
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7255
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7255
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7243
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7243
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7236
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7236
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7236
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7236
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7235
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7235
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7227
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7227
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7222
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7222
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7214
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7214
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7214
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7214
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7193
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7193
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7187
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7187
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7182
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7182
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7178
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7178
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7173
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7173
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7164
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7164
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7162
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7162
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7155
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7155
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 4 0.7151
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 4 0.7151
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7145
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7145
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7144
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7144
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7142
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7142
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7141
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7141
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7141
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7141
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 4 0.7137
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 4 0.7137
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7132
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7132
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7127
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7127
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7127
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7127
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7125
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7125
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7120
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7120
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7119
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7119
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7116
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7116
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7114
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7114
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7106
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7106
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7092
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7092
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7088
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7088
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7083
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.7083
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.7083
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7083
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7081
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7081
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7081
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7081
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7080
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7080
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7077
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7077
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 3 0.7074
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 3 0.7074
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7073
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7073
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7067
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7067
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7066
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7066
6-phosphogluconate dehydrogenase, decarboxylating P96789 6PGD_LACLM Lactococcus lactis subsp. cremoris 3 0.7065
6-phosphogluconate dehydrogenase, decarboxylating P96789 6PGD_LACLM Lactococcus lactis subsp. cremoris 3 0.7065
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7063
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7063
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7059
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7059
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7058
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7058
Nucleoside diphosphate kinase Q9U1E1 Q9U1E1_LEIMA Leishmania major 3 0.7051
Nucleoside diphosphate kinase Q9U1E1 Q9U1E1_LEIMA Leishmania major 3 0.7051
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7049
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7049
UDP-N-acetylmuramoylalanine--D-glutamate ligase P14900 MURD_ECOLI Escherichia coli 2 0.7048
UDP-N-acetylmuramoylalanine--D-glutamate ligase P14900 MURD_ECOLI Escherichia coli 2 0.7048
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7045
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7045
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.7044
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.7044
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7031
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7031
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7030
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7030
ATP-dependent helicase/nuclease subunit A P23478 ADDA_BACSU Bacillus subtilis 2 0.7028
ATP-dependent helicase/nuclease subunit A P23478 ADDA_BACSU Bacillus subtilis 2 0.7028
Pyruvate:ferredoxin oxidoreductase P94692 PFOR_DESAF Desulfocurvibacter africanus 3 0.7023
Pyruvate:ferredoxin oxidoreductase P94692 PFOR_DESAF Desulfocurvibacter africanus 3 0.7023
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7021
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7021
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7019
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7019
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7018
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7018
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7016
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7016
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7011
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7011
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7005
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7005
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7004
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7004

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