Justiciamide - Compound Card

Justiciamide

Select a section from the left sidebar

Justiciamide

Structure
Zoomed Structure
  • Family: Plantae - Acanthaceae
  • Kingdom: Plantae
  • Class: Amide
    • Subclass: Amide Of Hydroxyglutamic Acid
Canonical Smiles COc1cc(NC(=O)[C@H](C[C@@H](C(=O)O)N)O)c(cc1OC)O
InChI InChI=1S/C13H18N2O7/c1-21-10-4-7(8(16)5-11(10)22-2)15-12(18)9(17)3-6(14)13(19)20/h4-6,9,16-17H,3,14H2,1-2H3,(H,15,18)(H,19,20)/t6-,9-/m0/s1
InChIKey VNFIARTUELZYAE-RCOVLWMOSA-N
Formula C13H18N2O7
HBA 7
HBD 5
MW 314.29
Rotatable Bonds 7
TPSA 151.34
LogP -0.49
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.38
Exact Mass 314.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Justicia ghiesbreghtiana Acanthaceae Plantae 141992

Showing of synonyms

  • Lorenz P, Stermitz FR and Ismail LD. (1999). An amide of L-threo-gamma-hydroxyglutamic acid from Justicia ghiesbreghtiana. Phytochemistry,1999,52(1),63-66. [View] [PubMed]
Pubchem: 11723138
Nmrshiftdb2: 70071510

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 314.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-6.1
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.480
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-4.72

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.410
Plasma Protein Binding
21.25
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.930
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
-1.430
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.650
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
8.540
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.520
Rat (Acute)
2.070
Rat (Chronic Oral)
2.840
Fathead Minnow
3.870
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
434.900
Hydration Free Energy
-8.430
Log(D) at pH=7.4
-2.120
Log(P)
-2.76
Log S
-1.3
Log(Vapor Pressure)
-11.32
Melting Point
192.73
pKa Acid
3.17
pKa Basic
7.55
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9563
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9563
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9553
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9553
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9536
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9536
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9382
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9382
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9340
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9340
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9256
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9256
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9248
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9248
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9211
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9211
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.9098
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.9098
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9060
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9060
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9011
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9011
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8968
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8968
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8957
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8957
Tyrosyl-DNA phosphodiesterase 2 Q9JJX7 TYDP2_MOUSE Mus musculus 3 0.8853
Tyrosyl-DNA phosphodiesterase 2 Q9JJX7 TYDP2_MOUSE Mus musculus 3 0.8853
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8848
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8848
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8837
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8837
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8829
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8829
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8805
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8805
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.8784
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.8784
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8774
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8774
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8773
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8773
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.8766
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.8766
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8665
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8665
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8656
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8656
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 5 0.8647
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 5 0.8647
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8635
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8635
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8610
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8610
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.8606
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.8606
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8585
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8585
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8576
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8576
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8555
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8555
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8543
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8543
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8524
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8524
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8505
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8505
Nucleoside diphosphate kinase O58429 NDK_PYRHO Pyrococcus horikoshii 3 0.8442
Nucleoside diphosphate kinase O58429 NDK_PYRHO Pyrococcus horikoshii 3 0.8442
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8430
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8430
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8419
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8419
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8378
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8378
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8351
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8351
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8326
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8326
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8324
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8324
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8233
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8233
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8232
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8232
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8203
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8203
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8198
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8198
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8190
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8190
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 3 0.8177
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 3 0.8177
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8134
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8134
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 3 0.8121
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 3 0.8121
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8077
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8077
Putative choline kinase Q5CUP2 Q5CUP2_CRYPI Cryptosporidium parvum 3 0.8042
Putative choline kinase Q5CUP2 Q5CUP2_CRYPI Cryptosporidium parvum 3 0.8042
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 3 0.8037
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 3 0.8037
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.8031
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.8031
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7974
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7974
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7956
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7956
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7920
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7920
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7910
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7910
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.7849
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.7849
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.7844
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.7844
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7831
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7831
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7820
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7820
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7790
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7790
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7787
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7787
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7784
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7784
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7783
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7783
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7754
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7754
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7751
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7751
2-dehydro-3-deoxyphosphooctonate aldolase P0A715 KDSA_ECOLI Escherichia coli 3 0.7730
2-dehydro-3-deoxyphosphooctonate aldolase P0A715 KDSA_ECOLI Escherichia coli 3 0.7730
Proline--tRNA ligase Q8I5R7 SYP_PLAF7 Plasmodium falciparum 3 0.7705
Proline--tRNA ligase Q8I5R7 SYP_PLAF7 Plasmodium falciparum 3 0.7705
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7695
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7695
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 4 0.7680
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 4 0.7680
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 3 0.7678
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 3 0.7678
Regucalcin Q64374 RGN_MOUSE Mus musculus 3 0.7668
Regucalcin Q64374 RGN_MOUSE Mus musculus 3 0.7668
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7622
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7622
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7609
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7609
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7591
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7591
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7577
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7577
Polyamine oxidase FMS1 P50264 FMS1_YEAST Saccharomyces cerevisiae 3 0.7577
Polyamine oxidase FMS1 P50264 FMS1_YEAST Saccharomyces cerevisiae 3 0.7577
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7570
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7570
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7540
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7540
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7537
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7537
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7527
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7527
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7525
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7525
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7503
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7503
Proline--tRNA ligase Q8I5R7 SYP_PLAF7 Plasmodium falciparum 3 0.7502
Proline--tRNA ligase Q8I5R7 SYP_PLAF7 Plasmodium falciparum 3 0.7502
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7484
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7484
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7472
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7472
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7469
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7469
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7454
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7454
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7447
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7447
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7447
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7447
Biphenyl dioxygenase ferredoxin reductase subunit E7FJB9 E7FJB9_9BURK Acidovorax sp. KKS102 3 0.7446
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7446
Biphenyl dioxygenase ferredoxin reductase subunit E7FJB9 E7FJB9_9BURK Acidovorax sp. KKS102 3 0.7446
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7446
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7433
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7433
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7417
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7417
Aminopeptidase A2V759 A2V759_9BACL Aneurinibacillus sp. AM-1 4 0.7410
Aminopeptidase A2V759 A2V759_9BACL Aneurinibacillus sp. AM-1 4 0.7410
RNA-directed RNA polymerase P11124 RDRP_BPPH6 Pseudomonas phage phi6 3 0.7409
RNA-directed RNA polymerase P11124 RDRP_BPPH6 Pseudomonas phage phi6 3 0.7409
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7403
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7403
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7397
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7397
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7397
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7397
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7379
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7379
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7367
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7367
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 4 0.7364
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 4 0.7364
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7362
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7362
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7359
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7359
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 3 0.7350
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 3 0.7350
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7349
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7349
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7349
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7349
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7346
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7346
mRNA cleavage and polyadenylation factor CLP1 Q08685 CLP1_YEAST Saccharomyces cerevisiae 4 0.7344
mRNA cleavage and polyadenylation factor CLP1 Q08685 CLP1_YEAST Saccharomyces cerevisiae 4 0.7344
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7334
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7334
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7327
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7327
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7327
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7327
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7322
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7322
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7320
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7320
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7318
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7318
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7316
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7316
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7300
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7300
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7291
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7291
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7270
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7270
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.7270
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.7270
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7256
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7256
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7249
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7249
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7248
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7248
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7248
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7248
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7245
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7245
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7244
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7244
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7242
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7242
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7236
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7236
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7224
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7224
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7222
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7222
Mitomycin-binding protein O05205 O05205_STRLA Streptomyces lavendulae 2 0.7219
Mitomycin-binding protein O05205 O05205_STRLA Streptomyces lavendulae 2 0.7219
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7218
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7218
Glycerol kinase P0A6F3 GLPK_ECOLI Escherichia coli 4 0.7201
Glycerol kinase P0A6F3 GLPK_ECOLI Escherichia coli 4 0.7201
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7197
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7197
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7195
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7195
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7193
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7193
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7187
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7187
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7182
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7182
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7180
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7180
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7179
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7179
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 3 0.7168
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 3 0.7168
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7163
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7163
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7155
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7155
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7154
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7154
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7152
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7152
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7121
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7121
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7118
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7118
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7116
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7116
2'-5'-oligoadenylate synthase 1 P00973 OAS1_HUMAN Homo sapiens 2 0.7115
2'-5'-oligoadenylate synthase 1 P00973 OAS1_HUMAN Homo sapiens 2 0.7115
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7113
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7113
Thymidylate kinase P9WKE1 KTHY_MYCTU Mycobacterium tuberculosis 4 0.7108
Thymidylate kinase P9WKE1 KTHY_MYCTU Mycobacterium tuberculosis 4 0.7108
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7107
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7107
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 3 0.7101
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 3 0.7101
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7097
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7097
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7094
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7094
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7092
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7092
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7090
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7090
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7087
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7087
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7082
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7082
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7081
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7081
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7079
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7079
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7078
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7078
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7076
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7076
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7076
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7076
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7075
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7075
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7074
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7074
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7074
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7074
Nucleoside diphosphate kinase, cytosolic P22887 NDKC_DICDI Dictyostelium discoideum 3 0.7071
Nucleoside diphosphate kinase, cytosolic P22887 NDKC_DICDI Dictyostelium discoideum 3 0.7071
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7070
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7070
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7064
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7064
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.7055
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.7055
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7048
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7048
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7046
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7046
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7044
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7044
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7044
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7044
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7044
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7044
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7039
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7039
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7032
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7032
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7023
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7023
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7015
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7015
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7014
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7014
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7014
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7014
Succinate-semialdehyde dehydrogenase, mitochondrial P51649 SSDH_HUMAN Homo sapiens 4 0.7008
Succinate-semialdehyde dehydrogenase, mitochondrial P51649 SSDH_HUMAN Homo sapiens 4 0.7008
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7006
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7006
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7006
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7006
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7005
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7005
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7003
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7003
Glycerol kinase P0A6F3 GLPK_ECOLI Escherichia coli 4 0.7001
Glycerol kinase P0A6F3 GLPK_ECOLI Escherichia coli 4 0.7001
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7000
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7000

Download SDF