Quercitrin - Compound Card

Quercitrin

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Quercitrin

Structure
Zoomed Structure
  • Family: Plantae - Umbelliferae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Glycoside
Canonical Smiles Oc1cc(O)c2c(c1)oc(c(c2=O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)c1ccc(c(c1)O)O
InChI InChI=1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-26,28-29H,1H3/t7-,15-,17+,18+,21-/m0/s1
InChIKey OXGUCUVFOIWWQJ-HQBVPOQASA-N
Formula C21H20O11
HBA 11
HBD 7
MW 448.38
Rotatable Bonds 3
TPSA 190.28
LogP 0.49
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 32
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 448.1
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Viburnum tinus Adoxaceae Plantae 237959
2 Borago officinalis Boraginaceae Plantae 13363
3 Echium sericeum Boraginaceae Plantae 3046404
4 Helianthemum sessiliflorum Cistaceae Plantae 2650562
5 Ephedra alata Ephedraceae Plantae 302006
6 Euphorbia species Euphorbiaceae Plantae 1501592
7 Euphorbia helioscopia Euphorbiaceae Plantae 154990
8 Jatropha multifida Euphorbiaceae Plantae 3996
9 Euphorbia retusa Euphorbiaceae Plantae 1091645
10 Quercus suber Fagaceae Plantae 58331
11 Epilobium hirsutum Onagraceae Plantae 210355
12 Argania spinosa Sapotaceae Plantae 2945705
13 Coriandrum sativum Apiaceae Plantae 4047
14 Tetraclinis articulata Cupressaceae Plantae 13717
15 Warburgia ugandensis Canellaceae Plantae 549619
16 Ficus sur Moraceae Plantae 100575
17 Embelia schimperi Myrsinaceae Plantae 2595069
18 Embelia schimperi Myrsinaceae Plantae 2595069
19 Myrsine africana Myrsinaceae Plantae 59982
20 Eucalyptus globulous maidenii Myrtaceae Plantae 3932
21 Embelia schimperi Myrsinaceae Plantae 2595069
22 Pseudospondias microcarpa Anacardiaceae Plantae 1321805
23 Hypericum riparium Hypericaceae Plantae 269018
24 Euphorbia gaditana Euphorbiaceae Plantae 3990
25 Euphorbia sanctae-catharinae Euphorbiaceae Plantae 3990
26 Rhamnus disperma Rhamnaceae Plantae 1813078
27 Tamarix balansae Tamaricaceae Plantae 512632
28 Ferula longipes Umbelliferae Plantae 1514033

Showing of synonyms

  • Arot LO, Williams LA. (1997). A flavonol glycoside from Embelia schimperi leaves.. Phytochemistry,1997,44(7),1397-1398. [View] [PubMed]
  • Manguro LO, Mukonyi KW, et al. (1995). A New Flavonol Glycoside from Eucalyptus globulous Subsp. Maidenii.. Natural Product Letters,1995,7(3),163-167. [View] [PubMed]
  • Manguro LO, Midiwo JO, et al. (1996). A new flavonol Tetraglycoside from Myrsine africana leaves.. Natural Product Letters,1996,9(2),121-126. [View] [PubMed]
  • Tala MF, Talontsi FM, et al. (2015). Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium.. Fitoterapia,2015, 102, 149-155. [View] [PubMed]
  • Msaada K, Ben Jemia M, et al. (2014). Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties. Arabian Journal of Chemistry,2014, in press. [View]
  • Badaoui M, Magid A, et al. (2020). Antioxidant activity-guided isolation of constituents from Euphorbia gaditana Coss. and their antioxidant and tyrosinase inhibitory activities. Phytochemistry Letters, 2020, 39, 99-104. [View]
  • Klika KD, Khallouki F, et al. (2015). Carboxy methyl and carboxy analogs argaminolics B and C. Records of Natural Products,2015,9(4),597-602. [View]
  • Bouratoua A, Khalfallah A, et al. (2018). Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury. Nat Prod Res,2018,32(16),1873-1880. [View] [PubMed]
  • Zemmouri H, Ammar S, et al. (2014). Chemical composition and antioxidant activity of Borago officinalis L. leaf extract growing in Algeria. Arabian Journal of Chemistry,2014,in press. [View]
  • Benmerache A, Benteldjoune M, et al. (2017). Chemical composition, antioxidant and antibacterial activities of Tamarix balansae J. Gay aerial parts. Nat Prod Res,2017,31(24),2828-2835. [View] [PubMed]
  • Ito H, Yamaguchi K, et al. (2002). Dimeric and trimeric hydrolyzable tannins from Quercus coccifera and Quercus suber. Journal of Natural Products,2002,65(3),339-345. [View] [PubMed]
  • Mohamed AH, Hegazy MF, et al. (2012). Euphorbia helioscopia: Chemical constituents and biological activities. International Journal of Phytopharmacology,2012,3(1),78-90. [View]
  • Hegazy M.F, Hamed A.R, et al. (2018). Euphosantianane A–D: Antiproliferative premyrsinane diterpenoids from the endemic Egyptian plant Euphorbia sanctae-atharinae. Molecules, 2018, 23(9), 2221. [View] [PubMed]
  • Nawwar MAM, El-Sissi HI, et al. (1984). Flavonoid constituents of Ephedra alata. Phytochemistry,1984,23(12),2937-2939. [View]
  • Saleh NAM (1985). Flavonol glycosides of Euphorbia retusa and E. sanctae-catharinae. Phytochemistry,1985,24(2),371-372. [View]
  • Manguro LO, Ugi I, et al. (2003). Flavonol glycosides of Warburgia ugandensis leaves. Phytochemistry,2003,64(4),891-896. [View] [PubMed]
  • Manguro LO, Ugi I, et al. (2004). Further flavonol glycosides of Embelia schimperi leaves.. Bulletin of the Chemical Society of Ethiopia,2004,18(1),51-57. [View] [PubMed]
  • Hussein G, Miyashiro H, et al. (2000). Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease.. Phytotherapy Research,2000,14(7),510-516. [View] [PubMed]
  • Greenham JR, Grayer RJ, et al. (2007). Intra-and interspecific variations in vacuolar flavonoids among Ficus species from the Budongo Forest, Uganda.. Biochemical systematics and ecology,2007,35(2),81-90. [View] [PubMed]
  • Benabdelaziz I, Haba H, et al. (2015). Lignans and other constituents from Helianthemum sessiliflorum Pers.. Records of Natural Products,2015,9(3),342-348. [View]
  • Marzouk MS, Moharram FA, et al. (2012). Novel biflavone diglycosides and biological activity of Jatropha multifida leaves. Chemistry of Natural Compounds,2012,48(5),765-770. [View]
  • Guetchueng ST, Nahar L, et al. (2020). Phenolic compounds from the leaves and stem bark of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae). Biochemical Systematics and Ecology, 2020, 91, 104078. [View]
  • Zidane A, Tits M, et al. (2014). Phytochemical analysis of Tetraclinis articula in relation to its vasorelaxant property. Journal of Materials and Environmental Sciences,2014,5(5),1368-1375. [View]
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  • Mohamed MA, Marzouk MSA, et al. (2005). Phytochemical constituents and hepatoprotective activity of Viburnum tinus. Phytochemistry,2005,66,2780-2786. [View] [PubMed]
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Pubchem: 5280459
Kegg Ligand: C01750
Chebi: 17558
Nmrshiftdb2: 60021620
Metabolights: MTBLC17558
Pdb Ligand: QCT
Bindingdb: 50056315
CPRiL: 28255
Structure

SMILES: c1cccc(c12)oc(-c3ccccc3)c(c2=O)OC4CCCCO4

Level: 2

Mol. Weight: 448.38 g/mol

Structure

SMILES: c1cccc(c12)occ(c2=O)OC3CCCCO3

Level: 1

Mol. Weight: 448.38 g/mol

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 448.38 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 448.38 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 448.38 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 448.38 g/mol

Anti-hcv protease
Antihypertensive
Antioxidant

Absorption

Caco-2 (logPapp)
-6.72
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Non-Absorbed
Madin-Darby Canine Kidney
-5.61
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
0.89

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.89
Plasma Protein Binding
85.11
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
14.36
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
-1.77
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.21
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.64
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-62.04
Rat (Acute)
2.36
Rat (Chronic Oral)
3.97
Fathead Minnow
3.7
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
626.97
Hydration Free Energy
-6.04
Log(D) at pH=7.4
0.57
Log(P)
1.38
Log S
-4.16
Log(Vapor Pressure)
-11.41
Melting Point
207.35
pKa Acid
4.68
pKa Basic
7.49
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9738
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9738
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9267
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9267
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 8 0.9176
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 8 0.9176
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9041
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9041
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9013
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9013
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8961
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8961
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8956
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8956
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8830
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8830
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8460
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8460
Aldos-2-ulose dehydratase P84193 AUD_PHACH Phanerodontia chrysosporium 3 0.8460
Aldos-2-ulose dehydratase P84193 AUD_PHACH Phanerodontia chrysosporium 3 0.8460
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8431
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8431
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8424
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8424
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8417
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8417
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8372
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8372
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8309
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8309
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8276
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8276
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8216
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8216
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8182
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8182
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8170
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8170
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8050
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8050
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8005
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8005
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.7969
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.7969
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.7908
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.7908
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7892
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7892
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7881
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7881
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7830
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7830
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7816
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7816
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7813
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7813
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7751
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7751
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7744
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7744
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7741
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7741
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7733
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7733
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7732
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7732
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7645
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7645
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7583
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7583
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7577
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7577
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7564
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7564
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.7563
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.7563
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7553
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7553
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7489
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7489
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7361
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7361
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7355
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7355
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7325
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7325
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7255
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7255
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7249
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7249
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7230
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7230
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7207
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7207
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7171
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7171
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7119
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7119
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7104
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7104
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7067
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7067
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7056
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7056
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7025
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7025
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7019
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7019
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7015
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7015
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7002
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7002

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