(S)-4-methoxy-7-phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]isochromen-5-one - Compound Card

(S)-4-methoxy-7-phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]isochromen-5-one

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(S)-4-methoxy-7-phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]isochromen-5-one

Structure
Zoomed Structure
  • Family: Plantae - Amaranthaceae
  • Kingdom: Plantae
  • Class: Coumarin
    • Subclass: Dihydroisocoumarin
Canonical Smiles COc1c2C(=O)O[C@@H](Cc2cc2c1OCO2)c1ccccc1
InChI InChI=1S/C17H14O5/c1-19-16-14-11(8-13-15(16)21-9-20-13)7-12(22-17(14)18)10-5-3-2-4-6-10/h2-6,8,12H,7,9H2,1H3/t12-/m0/s1
InChIKey HIWRPYQCEDHZSU-LBPRGKRZSA-N
Formula C17H14O5
HBA 5
HBD 0
MW 298.29
Rotatable Bonds 2
TPSA 53.99
LogP 2.88
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 298.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Haloxylon scoparium Amaranthaceae Plantae 1665493

Showing of synonyms

  • Li Y, Plitzko I, et al. (2010). HPLC-based activity profiling for GABAA receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium. Journal of Natural Products,2010,73(4),768-770. [View] [PubMed]
Pubchem: 46210741
Nmrshiftdb2: 70110324

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)cc3c(c2)C(=O)OC(C3)c4ccccc4

Level: 1

Mol. Weight: 298.29 g/mol

Structure

SMILES: O1COc(c12)cc3c(c2)C(=O)OCC3

Level: 0

Mol. Weight: 298.29 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 298.29 g/mol

Gaba induction

Absorption

Caco-2 (logPapp)
-4.75
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.650
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.57

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.290
Plasma Protein Binding
75.76
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.280
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.320
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.580
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
5.850
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.550
Rat (Acute)
2.210
Rat (Chronic Oral)
1.540
Fathead Minnow
4.870
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
400.110
Hydration Free Energy
-7.280
Log(D) at pH=7.4
3.020
Log(P)
3.1
Log S
-4.07
Log(Vapor Pressure)
-6.98
Melting Point
127.09
pKa Acid
9.47
pKa Basic
2.69
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9912
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9912
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9605
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9605
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9496
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9496
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9433
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9433
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9405
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9405
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9359
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9359
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9317
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9317
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9288
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9288
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9247
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9247
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9187
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9187
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9011
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9011
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.9003
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.9003
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8988
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8988
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8986
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8986
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8945
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8945
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8926
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8926
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8893
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8893
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8860
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8860
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8803
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8803
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8753
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8753
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8694
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8694
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8670
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8670
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8660
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8660
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8626
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8626
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8618
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8618
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8610
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8610
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8608
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8608
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8589
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8589
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8520
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8520
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8516
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8516
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8508
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8508
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8506
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8506
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8504
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8504
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8466
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8466
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8445
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8445
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8436
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8436
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8418
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8418
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8286
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8286
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8228
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8228
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.8212
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.8212
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8169
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8169
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8158
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8158
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8025
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8025
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8009
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8009
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7984
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7984
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7941
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7941
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7901
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7901
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7895
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7895
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7893
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7893
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7879
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7879
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7863
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7863
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7857
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7857
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7848
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7848
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7841
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7841
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7797
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7797
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7791
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7791
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7784
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7784
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7751
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7751
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7749
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7749
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7749
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7749
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7740
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7740
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7701
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7701
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7692
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7692
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7674
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7674
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7669
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7669
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7639
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7639
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7625
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7625
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7610
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7610
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7604
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7604
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7555
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7555
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7519
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7519
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7497
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7497
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7495
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7495
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7476
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7476
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7465
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7465
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7454
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7454
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7426
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7426
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7422
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7422
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7419
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7419
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7414
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7414
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7413
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7413
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7407
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7407
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7403
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7403
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7385
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7385
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7380
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7380
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7377
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7377
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7375
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7375
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7366
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7366
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7353
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7353
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7330
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7330
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7326
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7326
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7314
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7314
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7303
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7303
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7298
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7298
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7291
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7291
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7284
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7284
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7283
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7283
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7276
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7276
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7272
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7272
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7271
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7271
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7265
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7265
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7264
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7264
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7238
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7238
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7224
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7224
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7220
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7220
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7219
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7219
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7219
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7219
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7217
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7217
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7217
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7217
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7215
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7215
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7215
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7215
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7212
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7212
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7206
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7206
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7182
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7182
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7178
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7178
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7168
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7168
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7166
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7166
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7165
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7165
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7158
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7158
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7152
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7152
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7152
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7152
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7146
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7146
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7145
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7145
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7137
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7137
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7137
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7137
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7134
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7134
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7134
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7134
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7128
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7128
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7123
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7123
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7121
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7121
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7115
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7115
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7112
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7112
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7101
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7101
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7099
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7099
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7096
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7096
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7095
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7095
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7093
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7093
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7091
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7091
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7086
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7086
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7082
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7082
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7079
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7079
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7064
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7064
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7063
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7063
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7061
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7061
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7058
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7058
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7055
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7055
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7054
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7054
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7054
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7054
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7051
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7051
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7047
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7047
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7041
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7041
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7032
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7032
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7024
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7024
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7022
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7022
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7021
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7021
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7021
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7021
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7016
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7016
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7014
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7014
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 3 0.7003
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 3 0.7003

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