Apigenin - Compound Card

Apigenin

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Apigenin

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae, Animalia
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles Oc1ccc(cc1)c1cc(=O)c2c(o1)cc(cc2O)O
InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChIKey KZNIFHPLKGYRTM-UHFFFAOYSA-N
Formula C15H10O5
HBA 5
HBD 3
MW 270.24
Rotatable Bonds 1
TPSA 90.9
LogP 2.58
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 270.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Allium myrianthum Amaryllidaceae Plantae 4678
2 Livistona australis Arecaceae Plantae 115491
3 Hyphaene thebaica Arecaceae Plantae 115479
4 Echium sericeum Boraginaceae Plantae 3046404
5 Artemisia judaica Asteraceae Plantae 205369
6 Artemisia monosperma Asteraceae Plantae 72348
7 Artemisia herba-alba Asteraceae Plantae 72329
8 Euphorbia species Euphorbiaceae Plantae 1501592
9 Chrozophora species Euphorbiaceae Plantae 316752
10 Moraea sisyrinchium Iridaceae Plantae 148530
11 Limonium axillare Plumbaginaceae Plantae 114150
12 Apis species Apidae Animalia 7459
13 Apis species Apidae Animalia 7459
14 Coriandrum sativum Apiaceae Plantae 4047
15 Chrysanthemum coronarium Asteraceae Plantae 99038
16 Centaurea nicaeensis Asteraceae Plantae 41503
17 Chrysanthemum macrocarpum Asteraceae Plantae 13422
18 Cynara cardunculus Asteraceae Plantae 4265
19 Centaurea alexandrina Asteraceae Plantae 363412
20 Centaurea calcitrapa Asteraceae Plantae 41511
21 Centaurea glomerata Asteraceae Plantae 363428
22 Centaurea pallescens Asteraceae Plantae 363441
23 Centaurea furfuracea Asteraceae Plantae 41503
24 Gaillardia aristata Asteraceae Plantae 55624
25 Launaea resedifolia Asteraceae Plantae 43198
26 Madia capitata Asteraceae Plantae 576756
27 Psiadia punctulata Asteraceae Plantae 72969
28 Ononis natrix Leguminosae/Fabaceae Plantae 200954

Showing of synonyms

  • Hammoud L, Seghiri R, et al. (2012). A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M.. Natural Product Research,2012,26(3),203-208. [View] [PubMed]
  • Kandil FE, Ahmed KM, et al. (2000). A new flavonoid from Limonium axillare. Archiv der Pharmazie,2000,333(8),275-277. [View] [PubMed]
  • Boutaghane N, Voutquenne-Nazabadioko L, et al. (2013). A new triterpenic diester from the aerial parts of Chrysanthemum macrocarpum. Phytochemistry Letters,2013,6,519-525. [View]
  • Kassem MES, Shoela S, et al. (2012). A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity. Natural Product Research,2012,26(15),1381-1387. [View] [PubMed]
  • Msaada K, Ben Jemia M, et al. (2014). Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties. Arabian Journal of Chemistry,2014, in press. [View]
  • Piccinelli AL, Mencherini T, et al. (2013). Chemical composition and antioxidant activity of Algerian propolis. Journal of Agricultural and Food Chemistry,2013,61(21),5080-5088. [View] [PubMed]
  • Mhamdi B, Abbassi F, et al. (2015). Chemical composition, antioxidant and antimicrobial activities of the edible medicinal Ononis natrix growing wild in Tunisia. Natural product research, 2015, 29(12), 1157-60. [View] [PubMed]
  • Salama MM, Kandil ZA and Islam WT. (2012). Cytotoxic compounds from the leaves of Gaillardia aristata Pursh. growing in Egypt. Natural Product Research,2012,26(22),2057-2062. [View] [PubMed]
  • Moussaoui F, Zellagui A, et al. (2010). Flavonoid constituents from Algerian Launaea resedifolia (O.K.) and their antimicrobial activity. Records of Natural Products,2010,4(1),91-95. [View]
  • Wollenweber E, Dörr M, et al. (2003). Flavonoids and terpenoids from the resinous exudates of Madia species (Asteraceae, Helenieae). Zeitschrift fur Naturforschung C,2003,58,153-160. [View] [PubMed]
  • Segueni N, Zellagui A, et al. (2016). Flavonoids from Algerian propolis. Arabian Journal of Chemistry,2016,9,S425-S428. [View]
  • El Shabrawy MOA, Hosni HA, et al. (2014). Flavonoids from Allium myrianthum Boiss.. Biochemical Systematics and Ecology,2014,56,125-128. [View]
  • Akkal S, Benayache F, et al. (2003). Flavonoids from Centaurea furfuracea (Asteraceae). Biochemical Systematics and Ecology,2003,31,641-643. [View]
  • El-Shabrawy MOA Marzouk MM, Kawashty SA, et al. (2013). Flavonoids from Moraea sisyrinchium (L.) Ker Gawl. (Iridaceae) in Egypt. International Conference on Applied Life Sciences (ICALS2013),2013,UAE. September 15-17, 2013. [View]
  • Saleh NAM, El-Negoumy SI, et al. (1987). Flavonoids of Artemisia judaica, A. monosperma and A. Herba-alba.. Phytochemistry,1987,26(11),3059-3064. [View]
  • Farag MA, El-Ahmady SH, et al. (2013). Metabolomics driven analysis of artichoke leaf and its commercial products via UHPLC–q-TOF-MS and chemometrics. Phytochemistry,2013,95,177-187. [View] [PubMed]
  • Ibrahim LF, El-Senousy WM, et al. (2007). NMR spectral analysis of flavonoids from Chrysanthemum coronarium. Chemistry of Natural Compounds,2007,43(6),659-662. [View]
  • Radwan HM, Shams KA, et al. (2007). Phytochemical and biological investigation of Echium sericeum (Vahl) growing in Egypt. Planta Medica,2007,73,334. [View]
  • Eldahshan OA, Ayoub NA, et al. (2008). Potential superoxide anion radical scavenging activity of doum palm (Hyphaene thebaica L.) leaves extract. Records of Natural Products,2008,2(3),83-93. [View]
  • Kawashty SA, Abdalla MF, et al. (1990). The chemosystematics of Egyptian Euphorbia species. Biochemical Systematics and Ecology,1990,18(7-8),487-490. [View]
  • Ahmed ZF, Rimpler H, et al. (1970). The flavonoid constituents of certain centaurea species grown in Egypt. Phytochemistry,1970,9,1595-1601. [View]
  • Hashim OK, Abou-Zaid MM, et al. (1990). The flavonoids of Egyptian Chrozophora species. Biochemical Systematics and Ecology,1990,18(2-3),151-152. [View]
  • Abou-Zaid MM, El-Karemy Z, et al. (1991). The flavonoids of Psiadia punctulata. Bulletin of the Chemical Society of Ethiopia,1991,5(1),37-40. [View]
Pubchem: 5280443
Kegg Ligand: C01477
Chebi: 18388
Nmrshiftdb2: 60018797
Metabolights: MTBLC18388
Chembl: CHEMBL28
Drugbank: DB07352
Pdb Ligand: AGI
Bindingdb: 7458
Selleck: Apigenin
CPRiL: 25415
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 270.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 270.24 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 270.24 g/mol

Antimicrobial
Cytotoxic

Absorption

Caco-2 (logPapp)
-4.95
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.950
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.46

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.810
Plasma Protein Binding
83.17
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.070
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.300
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.440
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.670
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.730
Rat (Acute)
2.140
Rat (Chronic Oral)
2.750
Fathead Minnow
4.470
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
467.600
Hydration Free Energy
-12.880
Log(D) at pH=7.4
3.260
Log(P)
3.18
Log S
-4.32
Log(Vapor Pressure)
-8.69
Melting Point
330.43
pKa Acid
6.72
pKa Basic
6.8
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9791
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9791
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9778
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9778
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9649
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9649
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9542
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9542
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9502
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9502
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9489
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9489
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9478
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9478
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.9416
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.9416
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9341
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9341
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9331
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9331
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9298
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9298
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9249
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9249
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9247
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9247
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9228
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9228
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9221
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9221
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9214
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9214
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9211
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9211
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9187
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9187
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9166
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9166
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9163
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9163
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9150
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9150
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9137
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9137
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9134
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9134
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9095
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9095
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9095
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9095
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9092
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9092
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9079
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9079
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.9052
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.9052
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9043
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9043
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9030
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9030
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9029
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9029
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8997
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8997
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8970
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8970
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8966
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8966
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8943
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8943
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8942
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8942
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8935
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8935
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8908
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8908
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8888
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8888
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8858
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8858
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8787
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8787
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8772
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8772
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8769
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8769
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8753
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8753
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8752
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8752
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8719
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8719
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8700
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8700
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8654
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8654
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8654
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8654
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8565
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8565
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8562
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8562
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8562
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8562
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8554
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8554
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8521
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8521
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8519
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8519
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8518
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8518
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8500
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8500
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8479
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8479
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8477
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8477
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8469
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8469
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.8443
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.8443
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8438
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8438
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8433
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8433
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8418
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8418
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8406
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8406
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8402
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8402
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8402
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8402
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8370
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8370
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8363
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8363
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8333
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8333
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8319
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8319
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8319
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8319
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8300
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8300
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8289
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8289
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8270
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8270
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8260
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8260
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8256
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8256
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8240
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8240
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8236
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8236
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8155
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8155
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8148
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8148
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8123
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8123
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8099
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8099
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8073
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8073
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8070
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8070
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8047
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8047
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8034
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8034
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8033
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8033
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8031
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8031
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8023
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8023
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8023
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8023
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8019
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8019
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8004
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8004
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8001
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8001
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7987
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7987
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7978
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7978
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7952
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7952
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7952
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7952
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7928
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7928
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7916
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7916
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7899
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7899
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7857
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7857
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7857
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7857
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7855
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7855
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7852
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7852
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7843
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7843
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7830
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7830
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7827
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7827
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7777
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7777
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7761
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7761
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7748
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7748
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7744
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7744
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7729
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7729
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7719
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7719
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7704
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7704
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7697
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7697
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7697
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7697
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7691
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7691
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7680
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7680
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7649
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7649
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7638
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7638
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7630
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7630
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7630
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7630
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7626
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7626
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7621
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7621
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7616
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7616
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7601
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7601
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7580
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7580
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7565
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7565
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7557
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7557
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7546
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7546
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7546
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7546
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7546
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7546
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7534
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7534
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7533
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7533
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7533
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7533
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7511
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7511
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7511
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7511
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7508
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7508
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7507
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7507
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7496
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7496
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7496
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7496
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7471
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7471
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7467
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7467
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7467
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7467
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7461
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7461
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7452
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7452
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7450
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7450
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7429
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7429
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7428
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7428
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7420
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7420
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7409
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7409
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7406
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7406
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7392
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7392
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7387
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7387
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7378
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7377
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7377
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7377
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7377
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7376
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7376
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7376
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7376
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7373
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7373
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7366
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7366
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7359
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7359
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7358
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7358
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7354
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7354
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7350
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7350
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7348
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7348
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7347
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7347
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7336
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7336
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7329
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7329
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7329
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7329
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7316
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7316
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7302
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7302
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7299
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7299
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7298
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7298
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7294
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7294
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7290
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7290
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7279
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7279
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7271
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7271
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7271
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7271
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7268
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7268
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7267
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7267
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7267
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7267
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7265
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7265
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7264
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7264
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7263
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7263
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7245
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7245
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7241
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7241
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7237
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7237
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7237
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7237
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7232
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7232
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7231
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7231
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7226
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7226
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7224
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7224
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7223
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7223
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7222
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7222
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7221
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7221
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7221
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7221
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7215
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7215
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7209
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7209
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7207
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7207
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7200
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7200
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7200
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7200
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7199
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7199
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7198
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7198
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7197
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7197
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7195
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7195
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7188
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7188
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7181
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7181
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7174
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7174
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7164
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7164
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7163
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7163
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7155
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7155
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7147
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7147
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7147
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7147
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7141
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7141
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7136
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7136
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7130
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7130
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7128
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7128
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7125
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7125
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7122
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7122
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7119
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7119
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7114
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7114
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7114
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7114
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7113
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7113
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7112
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7112
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7111
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7111
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7102
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7102
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7095
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7095
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7095
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7095
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7094
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7094
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7094
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7094
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7092
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7092
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7090
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7090
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7090
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7090
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7085
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7085
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7074
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7074
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7070
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7070
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7070
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7070
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7069
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7069
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7067
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7067
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7051
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7051
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7049
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7049
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7047
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7047
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7044
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7044
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7044
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7044
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7041
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7041
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7041
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7041
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7040
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7040
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7035
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7035
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7028
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7028
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7020
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7020
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7016
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7016
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7012
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7012
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7009
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7009
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7004
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7004
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7003
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7003
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7003
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7003

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