Luteolin - Compound Card

Luteolin

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Luteolin

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O
InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
InChIKey IQPNAANSBPBGFQ-UHFFFAOYSA-N
Formula C15H10O6
HBA 6
HBD 4
MW 286.24
Rotatable Bonds 1
TPSA 111.13
LogP 2.28
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 286.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Allium myrianthum Amaryllidaceae Plantae 4678
2 Livistona australis Arecaceae Plantae 115491
3 Hyphaene thebaica Arecaceae Plantae 115479
4 Pteranthus dichotomus Caryophyllaceae Plantae 325512
5 Anastatica hierochuntica Cruciferae-Brassicaceea Plantae 663965
6 Artemisia judaica Asteraceae Plantae 205369
7 Artemisia monosperma Asteraceae Plantae 72348
8 Artemisia herba-alba Asteraceae Plantae 72329
9 Euphorbia species Euphorbiaceae Plantae 1501592
10 Jatropha multifida Euphorbiaceae Plantae 3996
11 Chrozophora species Euphorbiaceae Plantae 316752
12 Limonium axillare Plumbaginaceae Plantae 114150
13 Hyparrhenia hirta Poaceae Plantae 42079
14 Cynara scolymus Asteraceae Plantae 59895
15 Coriandrum sativum Apiaceae Plantae 4047
16 Juniperus procera Cupressaceae Plantae 62753
17 Chrysanthemum coronarium Asteraceae Plantae 99038
18 Cynara cardunculus Asteraceae Plantae 4265
19 Cynara scolymus Asteraceae Plantae 59895
20 Cotula cinerea Asteraceae Plantae
21 Jasonia candicans Asteraceae Plantae 557631
22 Launaea resedifolia Asteraceae Plantae 43198
23 Madia anomala Asteraceae Plantae 71817
24 Madia capitata Asteraceae Plantae 576756
25 Madia citrigracilis Asteraceae Plantae 4253
26 Madia dissitiflora Asteraceae Plantae 907201
27 Psiadia punctulata Asteraceae Plantae 72969

Showing of synonyms

  • Kandil FE, Ahmed KM, et al. (2000). A new flavonoid from Limonium axillare. Archiv der Pharmazie,2000,333(8),275-277. [View] [PubMed]
  • Kassem MES, Shoela S, et al. (2012). A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity. Natural Product Research,2012,26(15),1381-1387. [View] [PubMed]
  • Msaada K, Ben Jemia M, et al. (2014). Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties. Arabian Journal of Chemistry,2014, in press. [View]
  • El Senousy AS, Farag MA, et al. (2014). Developmental changes in leaf phenolics composition from three artichoke cvs. (Cynara scolymus) as determined via UHPLC–MS and chemometrics. Phytochemistry,2014,108,67-76. [View] [PubMed]
  • Mujwah AA, Mohammed AM, et al. (2010). First isolation of a flavonoid from Juniperus procera using ethylacetate extract. Arabian Journal of Chemistry,2010,3,85-88. [View]
  • Moussaoui F, Zellagui A, et al. (2010). Flavonoid constituents from Algerian Launaea resedifolia (O.K.) and their antimicrobial activity. Records of Natural Products,2010,4(1),91-95. [View]
  • Wollenweber E, Dörr M, et al. (2003). Flavonoids and terpenoids from the resinous exudates of Madia species (Asteraceae, Helenieae). Zeitschrift fur Naturforschung C,2003,58,153-160. [View] [PubMed]
  • El Shabrawy MOA, Hosni HA, et al. (2014). Flavonoids from Allium myrianthum Boiss.. Biochemical Systematics and Ecology,2014,56,125-128. [View]
  • Bouaziz M, Simmonds MS, et al. (2001). Flavonoids from Hyparrhenia hirta Stapf (Poaceae) growing in Tunisia. Biochemical Systematics and Ecology,2001,29(8),849-851. [View] [PubMed]
  • Saleh NAM, El-Negoumy SI, et al. (1987). Flavonoids of Artemisia judaica, A. monosperma and A. Herba-alba.. Phytochemistry,1987,26(11),3059-3064. [View]
  • Ahmed AA, el-Sayed NH, et al. (1987). Flavonoids of Cotula cinerea. Journal of Natural Products,1987,50(3),519-520. [View]
  • Hammouda FM, Seif El-Nesr MM, et al. (1991). HPLC evaluation of the active constituents in the newly introduced romanian strain of Cynara scolymus cultivated in Egypt. Planta Medica,1991,57(2),A119-A120. [View]
  • Nakashima S, Matsuda H, et al. (2010). Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic and Medicinal Chemistry,2010,18(6),2337-2345. [View] [PubMed]
  • Farag MA, El-Ahmady SH, et al. (2013). Metabolomics driven analysis of artichoke leaf and its commercial products via UHPLC–q-TOF-MS and chemometrics. Phytochemistry,2013,95,177-187. [View] [PubMed]
  • Atta EM, Nassar AA, et al. (2013). New flavonoid glycoside and pharmacological activities of Pteranthus dichotomus Forssk.. Records of Natural Products,2013,7(2),69-79. [View]
  • Ibrahim LF, El-Senousy WM, et al. (2007). NMR spectral analysis of flavonoids from Chrysanthemum coronarium. Chemistry of Natural Compounds,2007,43(6),659-662. [View]
  • Marzouk MS, Moharram FA, et al. (2012). Novel biflavone diglycosides and biological activity of Jatropha multifida leaves. Chemistry of Natural Compounds,2012,48(5),765-770. [View]
  • Eldahshan OA, Ayoub NA, et al. (2008). Potential superoxide anion radical scavenging activity of doum palm (Hyphaene thebaica L.) leaves extract. Records of Natural Products,2008,2(3),83-93. [View]
  • Kawashty SA, Abdalla MF, et al. (1990). The chemosystematics of Egyptian Euphorbia species. Biochemical Systematics and Ecology,1990,18(7-8),487-490. [View]
  • Hashim OK, Abou-Zaid MM, et al. (1990). The flavonoids of Egyptian Chrozophora species. Biochemical Systematics and Ecology,1990,18(2-3),151-152. [View]
  • Abou-Zaid MM, El-Karemy Z, et al. (1991). The flavonoids of Psiadia punctulata. Bulletin of the Chemical Society of Ethiopia,1991,5(1),37-40. [View]
  • Ahmed AA, Mahmoud AA, et al. (1994). Two methylated flavonols from Jasonia candicans. Phytochemistry,1994,35(1),241-243. [View]
Pubchem: 5280445
Kegg Ligand: C01514
Chebi: 15864
Nmrshiftdb2: 60015826
Metabolights: MTBLC15864
Chembl: CHEMBL151
Drugbank: DB15584
Pdb Ligand: LU2
Bindingdb: 7459
CPRiL: 55210
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 286.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 286.24 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 286.24 g/mol

Anticancer

Absorption

Caco-2 (logPapp)
-5.15
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.15
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.11

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.78
Plasma Protein Binding
90.2
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.95
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.91
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.52
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.05
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.63
Rat (Acute)
2.3
Rat (Chronic Oral)
3.13
Fathead Minnow
4.25
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
489.65
Hydration Free Energy
-12.58
Log(D) at pH=7.4
2.64
Log(P)
2.74
Log S
-3.87
Log(Vapor Pressure)
-8.92
Melting Point
342.36
pKa Acid
6.24
pKa Basic
7.74
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9774
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9774
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9583
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9583
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9451
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9451
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9273
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9273
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9268
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9268
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9198
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9198
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9176
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9176
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9163
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9163
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9088
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9088
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9057
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9057
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9033
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9033
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8983
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8983
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8982
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8982
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8967
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8967
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8953
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8953
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8924
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8924
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8906
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8906
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8905
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8905
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8893
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8893
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8890
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8890
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8882
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8882
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8871
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8871
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8838
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8838
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8826
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8826
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8807
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8807
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8800
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8800
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8792
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8792
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8781
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8781
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8760
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8760
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8700
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8700
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8698
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8698
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8666
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8666
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8666
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8666
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8659
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8659
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8659
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8659
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8647
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8647
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8645
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8645
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8637
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8637
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8627
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8627
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8622
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8622
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8588
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8588
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8584
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8584
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8555
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8555
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8553
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8553
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8540
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8540
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8535
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8535
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8521
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8521
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8518
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8518
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8512
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8512
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8499
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8499
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8494
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8494
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8493
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8493
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8491
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8491
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8477
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8477
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8473
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8473
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8421
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8421
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8418
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8418
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8394
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8394
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8389
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8389
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8379
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8379
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8364
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8364
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8335
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8335
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8326
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8326
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8315
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8315
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8297
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8297
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8295
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8295
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8294
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8294
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8291
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8291
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8258
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8258
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8247
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8247
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8238
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8238
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8230
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8230
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8225
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8225
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8213
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8213
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8201
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8201
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8186
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8186
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8179
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8179
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8155
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8155
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8154
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8154
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8149
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8149
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8142
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8142
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8138
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8138
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8137
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8137
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8125
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8125
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8076
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8076
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.8041
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.8041
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8000
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8000
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7963
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7963
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7959
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7959
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7953
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7953
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7951
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7951
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7923
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7923
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7916
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7916
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7913
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7913
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7891
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7891
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7888
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7888
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7884
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7884
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7882
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7882
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7878
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7878
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7847
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7847
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7833
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7833
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7832
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7832
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7806
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7806
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7771
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7771
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7768
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7768
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7754
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7754
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7738
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7738
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7720
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7720
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7713
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7713
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7692
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7692
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7691
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7691
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7681
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7681
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7677
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7677
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.7673
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7673
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.7673
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7673
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7671
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7671
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7668
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7668
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7660
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7660
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7653
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7653
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7653
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7653
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7643
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7643
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7614
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7614
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7612
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7612
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7594
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7594
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7593
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7593
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7592
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7592
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7588
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7588
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7559
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7559
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7548
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7548
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7547
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7547
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7544
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7544
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7515
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7515
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7485
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7485
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7472
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7472
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7472
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7472
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7471
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7471
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7459
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7459
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7458
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7458
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7420
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7420
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7418
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7418
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7409
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7409
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7409
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7409
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7400
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7400
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7399
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7399
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7382
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7382
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7373
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7373
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7369
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7369
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7363
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7363
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7353
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7353
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7348
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7348
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7344
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7344
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7320
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7320
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7320
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7320
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7319
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7319
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7317
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7317
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7313
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7313
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7310
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7310
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7306
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7306
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7303
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7303
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7299
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7299
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7291
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7291
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7273
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7273
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7265
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7265
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7256
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7256
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7256
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7256
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7240
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7240
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7237
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7237
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7233
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7233
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7233
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7233
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7229
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7229
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7217
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7215
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7215
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7214
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7214
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7212
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7212
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7205
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7205
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7201
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7201
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7198
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7198
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7198
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7198
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7190
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7190
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7185
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7185
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7184
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7184
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7182
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7182
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7182
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7182
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7182
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7182
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7180
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7180
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7170
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7170
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7161
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7161
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7153
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7153
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7135
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7135
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7134
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7134
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7131
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7131
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7127
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7127
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7119
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7119
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7117
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7117
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7117
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7117
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7116
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7116
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7112
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7112
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7108
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7108
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7108
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7108
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7108
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7108
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7101
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7101
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7091
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7091
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7091
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7091
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7089
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7089
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7089
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7089
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7079
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7079
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7076
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7076
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7075
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7075
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7075
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7075
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7068
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7068
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7066
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7066
Methyltransferase domain-containing protein O57965 O57965_PYRHO Pyrococcus horikoshii 4 0.7063
Methyltransferase domain-containing protein O57965 O57965_PYRHO Pyrococcus horikoshii 4 0.7063
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7059
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7059
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7059
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7059
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7056
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7056
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7055
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7055
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7048
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7048
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7048
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7048
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7044
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7044
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7039
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7039
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7038
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7038
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7037
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7037
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7029
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7029
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7024
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7024
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7023
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7023
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7020
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7020
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7015
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7015
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7013
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7013
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7012
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7012
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7010
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7010
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7007
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7007
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7005
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7005

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