4-hydroxy-2',4 '-dimethoxy-dihydrochalcone - Compound Card

4-hydroxy-2',4 '-dimethoxy-dihydrochalcone

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4-hydroxy-2',4 '-dimethoxy-dihydrochalcone

Structure
Zoomed Structure
  • Family: Plantae - Amaryllidaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Chalcone
Canonical Smiles COc1cc(OC)ccc1C(=O)CCc1ccc(cc1)O
InChI InChI=1S/C17H18O4/c1-20-14-8-9-15(17(11-14)21-2)16(19)10-5-12-3-6-13(18)7-4-12/h3-4,6-9,11,18H,5,10H2,1-2H3
InChIKey PGBXUNIUTBHZMK-UHFFFAOYSA-N
Formula C17H18O4
HBA 4
HBD 1
MW 286.33
Rotatable Bonds 6
TPSA 55.76
LogP 3.22
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 286.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Crinum bulbispermum Amaryllidaceae Plantae 209086

Showing of synonyms

  • Ramadan MA, Kamel MS, et al. (2000). Minor phenolics from Crinum bulbispermum bulbs. Phytochemistry,2000,54(8),891-896. [View] [PubMed]
Pubchem: 15549893
Nmrshiftdb2: 70009211

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)CCc2ccccc2

Level: 1

Mol. Weight: 286.33 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 286.33 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.7
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.580
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.57

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.220
Plasma Protein Binding
60.61
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.860
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.390
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.780
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.290
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.160
Rat (Acute)
1.600
Rat (Chronic Oral)
2.180
Fathead Minnow
4.620
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
384.580
Hydration Free Energy
-9.280
Log(D) at pH=7.4
3.320
Log(P)
2.57
Log S
-4.44
Log(Vapor Pressure)
-6.22
Melting Point
80.41
pKa Acid
9.18
pKa Basic
4.85
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9921
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9921
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9815
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9815
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9694
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9694
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9669
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9669
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9636
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9636
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9626
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9626
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9565
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9565
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9546
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9546
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9529
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9529
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.9402
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.9402
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9386
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9386
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9376
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9376
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.9372
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.9372
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9349
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9349
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9338
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9338
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9334
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9334
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9330
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9330
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9328
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9328
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9278
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9278
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.9268
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.9268
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.9260
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.9260
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9244
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9244
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.9242
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.9242
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.9233
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.9233
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9232
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9232
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.9224
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.9224
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.9200
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.9200
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9169
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9169
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.9167
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.9167
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9162
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9162
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.9159
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.9159
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9129
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9129
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9128
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9128
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9119
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9119
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9111
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9111
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9071
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9071
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.9054
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.9054
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.9048
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.9048
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.9043
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.9043
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9026
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9026
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9022
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9022
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9017
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9017
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.9014
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.9014
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8994
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8994
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8991
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8991
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8990
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8990
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.8983
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.8983
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8968
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8968
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8968
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8968
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8968
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8968
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8956
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8956
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.8956
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.8956
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8945
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8945
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8931
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8931
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8929
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8929
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8927
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8927
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8923
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8923
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8917
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8917
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.8913
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.8913
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8900
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8900
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.8882
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.8882
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8872
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8872
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8870
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8870
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8855
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8855
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.8840
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.8840
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8838
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8838
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8804
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8804
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.8800
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.8800
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8762
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8762
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8760
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8760
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8743
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8743
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8730
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8730
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8721
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8721
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8698
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8698
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8691
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8691
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8685
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8685
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8679
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8679
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.8671
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.8671
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8647
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8647
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.8625
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.8625
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8612
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8612
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8607
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8607
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8606
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8606
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8605
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8605
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8604
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8604
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8598
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8598
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8589
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8589
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.8584
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8584
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.8584
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8584
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8567
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8567
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8567
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8567
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8557
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8557
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8555
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8555
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8542
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8542
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8542
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8542
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8503
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8503
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8502
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8502
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8500
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8500
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8500
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8500
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8494
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8494
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8453
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8453
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8446
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8446
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8445
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8445
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8433
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8433
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8430
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8430
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8426
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8426
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8411
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8411
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8410
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8410
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8394
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8394
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8392
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8392
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8386
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8386
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.8358
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.8358
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8356
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8356
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8339
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8339
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8333
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8333
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8316
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8316
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8310
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8310
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8299
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8299
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8292
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8292
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8291
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8291
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8289
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8289
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8285
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8285
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8247
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8247
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8225
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8225
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8210
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8210
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8208
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8208
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8203
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8203
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8200
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8200
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8183
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8183
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8166
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8166
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8159
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8159
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8151
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8151
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8147
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8147
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8147
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8147
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8120
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8120
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8102
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8102
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8096
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8096
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.8088
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.8088
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8080
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8080
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8078
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8078
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8077
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8077
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8060
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8060
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8054
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8054
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8040
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8040
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8034
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8034
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8027
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8027
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8023
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8023
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8012
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8012
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.8008
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.8008
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8004
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8004
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.8004
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.8004
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7997
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7997
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7989
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7989
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7987
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7987
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7987
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7987
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7972
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7972
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7969
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7969
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7932
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7932
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7914
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7914
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7908
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7908
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7902
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7902
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7896
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7896
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7891
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7891
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7867
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7867
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7859
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7859
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7849
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7849
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7847
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7847
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7841
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7841
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7835
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7835
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7835
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7835
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7831
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7831
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7823
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7823
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7817
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7817
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7816
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7816
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7814
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7814
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7800
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7800
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7794
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7794
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7793
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7793
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7781
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7781
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7781
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7781
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7780
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7780
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7776
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7776
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7775
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7775
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7767
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7767
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7764
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7764
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7764
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7764
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7758
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7758
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7757
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7757
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7753
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7753
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7750
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7750
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7742
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7742
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7728
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7728
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7713
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7713
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7712
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7712
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7711
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7711
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7711
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7711
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7709
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7709
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7708
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7708
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7694
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7694
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7689
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7689
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7685
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7685
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7683
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7683
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7683
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7683
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7681
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7681
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7678
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7678
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7674
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7674
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7670
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7670
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7668
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7668
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7666
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7666
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7662
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7662
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7659
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7659
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7651
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7651
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7639
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7639
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7638
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7638
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7637
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7637
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7631
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7631
Putative pteridine reductase 2 Q8I814 Q8I814_TRYCR Trypanosoma cruzi 4 0.7629
Putative pteridine reductase 2 Q8I814 Q8I814_TRYCR Trypanosoma cruzi 4 0.7629
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7625
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7625
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7613
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7613
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7608
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7608
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7608
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7608
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7605
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7605
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7600
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7600
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7600
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7600
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7599
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7599
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7599
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7599
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7594
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7594
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7592
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7592
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7591
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7591
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7584
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7584
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7581
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7581
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7576
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7576
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7574
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7574
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7572
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7572
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7566
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7566
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7563
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7563
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7558
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7558
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7553
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7553
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7552
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7552
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7552
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7552
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7551
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7551
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7550
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7550
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7549
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7549
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7548
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7548
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7547
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7547
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7547
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7547
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7543
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7543
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7542
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7542
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7537
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7537
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7531
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7531
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7527
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7527
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7523
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7523
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7523
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7523
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7520
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7520
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7515
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7515
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7514
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7514
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7512
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7512
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7502
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7502
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7501
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7501
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7501
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7501
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7495
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7495
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7495
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7495
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7493
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7493
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7493
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7493
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7487
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7487
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7484
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7484
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7484
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7484
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7480
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7480
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7480
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7480
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7479
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7479
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7479
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7479
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7477
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7477
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7474
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7474
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7473
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7473
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7472
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7472
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7471
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7471
Thymidylate synthase ThyA P9WFR9 TYSY_MYCTU Mycobacterium tuberculosis 3 0.7470
Thymidylate synthase ThyA P9WFR9 TYSY_MYCTU Mycobacterium tuberculosis 3 0.7470
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7466
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7466
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7466
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7466
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7463
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7463
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7461
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7461
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7461
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7461
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7461
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7461
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7460
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7460
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7455
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7455
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7453
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7453
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7453
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7453
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7449
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7449
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7449
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7449
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7446
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7446
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 4 0.7443
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 4 0.7443
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7440
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7440
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7439
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7439
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7439
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7439
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7438
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7438
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7437
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7437
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7436
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7436
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7434
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7434
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7432
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7432
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7429
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7429
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7427
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7427
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 3 0.7425
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 3 0.7425
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7425
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7425
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7423
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7423
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7423
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7423
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7422
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7422
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7421
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7421
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7420
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7420
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7419
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7419
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7416
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7416
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7414
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7414
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7409
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7409
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7404
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7404
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7403
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7403
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7402
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7402
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7400
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7400
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7399
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7399
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7399
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7399
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7398
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7398
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7396
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7396
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7392
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7392
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7392
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7392
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7389
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7389
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7387
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7387
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial P11310 ACADM_HUMAN Homo sapiens 3 0.7386
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial P11310 ACADM_HUMAN Homo sapiens 3 0.7386
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7385
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7385
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7384
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7384
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7379
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7379
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7376
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7376
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7376
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7376
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7374
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7374
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7372
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7372
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7372
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7372
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7371
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7371
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7368
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7368
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7364
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7364
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7363
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7363
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7357
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7357
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7356
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7356
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7355
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7355
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7354
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7354
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7353
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7353
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7349
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7349
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7349
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7349
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7349
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7349
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7347
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7347
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7347
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7347
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7339
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7339
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7338
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7338
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7337
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7337
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7335
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7335
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7334
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7334
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7333
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7333
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7330
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7330
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7330
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7330
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7324
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7324
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7323
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7323
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7323
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7323
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7320
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7320
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7319
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7319
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7318
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7318
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7317
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7317
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7317
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7317
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7312
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7312
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7311
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7311
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 2 0.7310
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 2 0.7310
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7309
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7309
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7308
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7308
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7308
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7308
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7308
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7308
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7304
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7304
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7304
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7304
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7303
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7303
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7303
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7303
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7301
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7301
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7299
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7299
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7298
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7298
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7298
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7298
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7297
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7297
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7297
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7297
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7296
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7296
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7294
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7294
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7292
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7292
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7292
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7292
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7292
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7292
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7291
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7291
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7291
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7291
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7291
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7291
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7290
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7290
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7290
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7290
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7289
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7289
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7284
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7284
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7283
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7283
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7280
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7280
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7276
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7276
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7276
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7276
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7276
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7276
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7275
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7275
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7273
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7273
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7272
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7272
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7271
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7271
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7270
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7270
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7265
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7265
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7263
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7263
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7261
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7261
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7258
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7258
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7258
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7258
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7257
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7257
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7253
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7253
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7253
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7253
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7252
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7252
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7251
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7251
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7248
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7248
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7246
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7246
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7246
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7246
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7246
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7246
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7244
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7244
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7243
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7243
Probable nicotinate-nucleotide adenylyltransferase Q9HX21 NADD_PSEAE Pseudomonas aeruginosa 3 0.7241
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
Probable nicotinate-nucleotide adenylyltransferase Q9HX21 NADD_PSEAE Pseudomonas aeruginosa 3 0.7241
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7240
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7240
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7238
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7238
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7236
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7236
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7236
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7236
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7234
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7234
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7234
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7234
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7232
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7232
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7231
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7231
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7227
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7227
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7227
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7227
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7226
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7226
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7225
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7225
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7225
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7225
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7221
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7221
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7219
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7219
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7218
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7218
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7216
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7216
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7210
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7210
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7210
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7210
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7209
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7209
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7208
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7208
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7208
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7208
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7204
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7204
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7197
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7197
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7196
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7196
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7190
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7190
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7189
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7189
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7189
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7189
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7189
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7189
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7187
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7187
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7187
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7187
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7187
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7187
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7185
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7185
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7180
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7180
Ribosome-inactivating protein dianthin-30 P24476 RIP0_DIACA Dianthus caryophyllus 3 0.7180
Ribosome-inactivating protein dianthin-30 P24476 RIP0_DIACA Dianthus caryophyllus 3 0.7180
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7179
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7179
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7178
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7178
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7178
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7178
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7177
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7177
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7175
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7175
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7175
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7175
Uridine phosphorylase P12758 UDP_ECOLI Escherichia coli 3 0.7174
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 3 0.7174
Uridine phosphorylase P12758 UDP_ECOLI Escherichia coli 3 0.7174
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 3 0.7174
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7171
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7171
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7170
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7170
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7170
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7170
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7165
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7165
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7163
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7163
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7162
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7162
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7162
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7162
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7158
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7158
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7157
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7157
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7155
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7155
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7153
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7153
UDP-3-O-acyl-N-acetylglucosamine deacetylase O67648 LPXC_AQUAE Aquifex aeolicus 3 0.7152
UDP-3-O-acyl-N-acetylglucosamine deacetylase O67648 LPXC_AQUAE Aquifex aeolicus 3 0.7152
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7152
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7152
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7150
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7150
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7149
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7149
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7149
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7149
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7146
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7146
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7145
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7145
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7143
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7143
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7142
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7142
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7142
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7142
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7142
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7142
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7140
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7140
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7138
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7138
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7137
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7137
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7136
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7136
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7135
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7135
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7135
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7135
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7134
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7134
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7134
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7134
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7132
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7132
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7132
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7132
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7127
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7127
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7127
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7127
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7126
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7126
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7122
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7122
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7122
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7122
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7120
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7120
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7119
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7119
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7119
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7119
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7118
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7118
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7116
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7116
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7116
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7116
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7114
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7114
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7112
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7112
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7112
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7112
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7111
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7111
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7111
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7111
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7110
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7110
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7109
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7109
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7106
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7106
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7104
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7104
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7103
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7103
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7102
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7102
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7102
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7102
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7101
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7100
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7100
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7098
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7098
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7098
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7098
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7096
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 3 0.7096
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7096
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 3 0.7096
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7096
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7096
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7095
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7095
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7094
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7094
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7093
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7093
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7090
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7090
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7088
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7088
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7087
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7087
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7086
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7086
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7086
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7086
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7084
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7084
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7081
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7081
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7081
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7081
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7081
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7081
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7080
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7080
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7079
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7079
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7076
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7076
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7073
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7073
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7073
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7073
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7070
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7070
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7067
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7067
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7067
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7067
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7065
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 3 0.7065
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 3 0.7065
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7065
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7062
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7062
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7062
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7062
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7061
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7061
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7060
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7060
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7059
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7059
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7058
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7058
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7058
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7058
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7056
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7056
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7055
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7055
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7052
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7052
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7051
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7051
Epothilone C/D epoxidase Q9KIZ4 C167_SORCE Sorangium cellulosum 2 0.7050
Epothilone C/D epoxidase Q9KIZ4 C167_SORCE Sorangium cellulosum 2 0.7050
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7047
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7047
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7045
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7045
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7045
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7045
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7045
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7045
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7044
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7044
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7037
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7037
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7036
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7036
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7034
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7034
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7033
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7033
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7032
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7032
Epoxide hydrolase B P95276 EPHB_MYCTO Mycobacterium tuberculosis 3 0.7029
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7029
Epoxide hydrolase B P95276 EPHB_MYCTO Mycobacterium tuberculosis 3 0.7029
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7029
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7029
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7029
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7028
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7028
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7025
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7025
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7024
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7024
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7023
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7023
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7023
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7023
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7023
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7023
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7021
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7021
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7021
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7021
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7018
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7018
Beta-ketoacyl-[acyl-carrier-protein] synthase III Q820T1 FABH_ENTFA Enterococcus faecalis 2 0.7017
Beta-ketoacyl-[acyl-carrier-protein] synthase III Q820T1 FABH_ENTFA Enterococcus faecalis 2 0.7017
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7014
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7014
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7012
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7012
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7012
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7012
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7009
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7009
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7007
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7007
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7007
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7007
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7005
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7005

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