Isolarrien - Compound Card

Isolarrien

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Isolarrien

Structure
Zoomed Structure
  • Family: Plantae - Amaryllidaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1c(O)ccc2c1O[C@@H](CC2=O)c1ccccc1
InChI InChI=1S/C16H14O4/c1-19-16-12(17)8-7-11-13(18)9-14(20-15(11)16)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1
InChIKey FYIPCBNZSKNQSP-AWEZNQCLSA-N
Formula C16H14O4
HBA 4
HBD 1
MW 270.28
Rotatable Bonds 2
TPSA 55.76
LogP 3.11
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 270.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Crinum bulbispermum Amaryllidaceae Plantae 209086

Showing of synonyms

  • Ramadan MA, Kamel MS, et al. (2000). Minor phenolics from Crinum bulbispermum bulbs. Phytochemistry,2000,54(8),891-896. [View] [PubMed]
Pubchem: 15549894
Nmrshiftdb2: 60066871

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 270.28 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 270.28 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 270.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.65
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.490
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.33

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.200
Plasma Protein Binding
82.5
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.180
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.200
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.740
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
5.660
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.610
Rat (Acute)
1.970
Rat (Chronic Oral)
2.180
Fathead Minnow
4.460
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
367.490
Hydration Free Energy
-7.630
Log(D) at pH=7.4
2.140
Log(P)
2.73
Log S
-4.16
Log(Vapor Pressure)
-6.58
Melting Point
125.04
pKa Acid
7.54
pKa Basic
3.29
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9883
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9883
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9812
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9812
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9715
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9715
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9653
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9653
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9642
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9642
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9597
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9597
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9585
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9585
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9574
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9574
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9565
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9565
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9508
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9508
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9504
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9504
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9452
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9452
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9435
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9435
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9422
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9422
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9414
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9414
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9393
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9393
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9327
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9327
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9286
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9286
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9264
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9264
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9223
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9223
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9222
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9222
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9136
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9136
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9118
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9118
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9090
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9090
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9085
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9085
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9052
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9052
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9052
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9052
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9011
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9011
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8987
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8987
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8969
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8969
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8921
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8921
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8890
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8890
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8787
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8787
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8784
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8784
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8737
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8737
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8732
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8732
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8701
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8701
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8685
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8685
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8680
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8680
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8666
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8666
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8655
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8655
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8653
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8653
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8651
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8651
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8648
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8648
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8635
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8635
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8631
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8631
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8629
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8629
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8625
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8625
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8615
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8615
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8606
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8606
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8592
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8592
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8575
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8575
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8565
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8565
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8565
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8565
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8563
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8563
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8545
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8545
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8534
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8534
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8515
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8515
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8503
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8503
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8479
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8479
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8454
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8454
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8454
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8454
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8441
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8441
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8421
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8421
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8416
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8416
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8406
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8406
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8402
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8402
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8369
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8369
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8358
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8358
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8333
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8333
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8327
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8327
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8316
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8316
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8264
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8264
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8249
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8249
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8233
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8233
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8231
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8231
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8229
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8229
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.8227
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.8227
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8217
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8217
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8216
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8216
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8213
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8213
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8205
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8205
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8180
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8180
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8179
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8179
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8172
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8172
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8166
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8166
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8159
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8159
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8157
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8157
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8153
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8153
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8143
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8143
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8140
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8140
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8091
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8091
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8075
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8075
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8043
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8043
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8042
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8042
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8035
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8035
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8021
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8021
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8012
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8012
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8010
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8010
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8008
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8008
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7978
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7978
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7956
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7956
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7950
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7950
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7943
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7943
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7932
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7932
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7932
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7932
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7928
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7928
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7924
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7924
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7924
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7924
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7922
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7922
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7884
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7884
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7878
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7878
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7862
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7862
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7858
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7858
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7828
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7828
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7817
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7817
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7800
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7800
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7769
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7769
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7764
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7764
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7752
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7752
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7737
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7737
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7736
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7736
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7727
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7727
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7727
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7727
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7726
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7726
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7718
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7718
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7704
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7704
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7701
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7701
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7695
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7695
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7689
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7689
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7678
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7678
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7677
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7677
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7670
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7670
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7661
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7661
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7657
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7657
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7657
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7657
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7624
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7624
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7611
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7611
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7602
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7602
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7596
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7596
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7595
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7595
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7575
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7575
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7570
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7570
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7569
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7569
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7563
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7563
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7553
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7553
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7547
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7547
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7537
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7537
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7534
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7534
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7529
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7529
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7521
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7521
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7517
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7517
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7516
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7516
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7512
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7512
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7512
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7512
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7508
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7508
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7504
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7504
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7497
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7497
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7493
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7493
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7491
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7491
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7490
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7490
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7484
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7484
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7478
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7478
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7476
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7476
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7452
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7452
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 3 0.7450
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 3 0.7450
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7436
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7436
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7430
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7430
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7423
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7423
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7404
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7404
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7401
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7401
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7400
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7400
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7398
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7398
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7396
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7396
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7393
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7393
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7388
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7388
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7388
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7388
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7376
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7376
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7375
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7375
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7370
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7370
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7366
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7366
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7362
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7362
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7350
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7350
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7342
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7342
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7337
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7337
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7330
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7330
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7330
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7330
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7323
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7323
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7317
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7317
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7317
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7317
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7311
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7311
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7309
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7309
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7303
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7303
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7292
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7292
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7280
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7280
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7274
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7274
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7272
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7272
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7269
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7269
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7267
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7267
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7259
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7259
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7258
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7258
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7248
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7248
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7246
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7246
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7242
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7242
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7241
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7241
Sphingosine 1-phosphate receptor 1 P21453 S1PR1_HUMAN Homo sapiens 3 0.7240
Sphingosine 1-phosphate receptor 1 P21453 S1PR1_HUMAN Homo sapiens 3 0.7240
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7237
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7237
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7237
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7237
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7236
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7236
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7234
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7234
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7228
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7228
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7218
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7218
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7218
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7218
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7213
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7213
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7212
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7212
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7205
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7205
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7198
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7198
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7196
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7196
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7195
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7195
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7191
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7191
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7190
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7190
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7186
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7186
Sphingosine 1-phosphate receptor 1 P21453 S1PR1_HUMAN Homo sapiens 3 0.7179
Sphingosine 1-phosphate receptor 1 P21453 S1PR1_HUMAN Homo sapiens 3 0.7179
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7176
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7176
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7176
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7176
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 4 0.7161
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 4 0.7161
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7158
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7158
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7158
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7158
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7155
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7155
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7154
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7154
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7153
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7153
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7146
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7146
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7133
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7133
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7130
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7130
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7129
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7129
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7117
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7117
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7116
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7116
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7114
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7114
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7113
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7113
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7107
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7107
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7104
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7104
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7102
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7102
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7099
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7099
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7095
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 3 0.7095
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7095
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 3 0.7095
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7094
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7094
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7086
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7086
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7081
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7081
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7079
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7079
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7070
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7070
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.7069
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.7069
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7068
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7068
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7065
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7065
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7058
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7058
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7057
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7057
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7054
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7054
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7045
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7045
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7040
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7040
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7034
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7034
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7023
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7023
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7015
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7015
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7011
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7011
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7007
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7007
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7005
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7005

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