4,5-methylenedioxy-4'-hydroxy-2-aldehyde[1,1'-biphenyl] - Compound Card

4,5-methylenedioxy-4'-hydroxy-2-aldehyde[1,1'-biphenyl]

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4,5-methylenedioxy-4'-hydroxy-2-aldehyde[1,1'-biphenyl]

Structure
Zoomed Structure
  • Family: Plantae - Amaryllidaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles O=Cc1cc2OCOc2cc1c1ccc(cc1)O
InChI InChI=1S/C14H10O4/c15-7-10-5-13-14(18-8-17-13)6-12(10)9-1-3-11(16)4-2-9/h1-7,16H,8H2
InChIKey CJLFWRBPNXIPHA-UHFFFAOYSA-N
Formula C14H10O4
HBA 4
HBD 1
MW 242.23
Rotatable Bonds 2
TPSA 55.76
LogP 2.6
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 242.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Crinum bulbispermum Amaryllidaceae Plantae 209086

Showing of synonyms

  • Ramadan MA, Kamel MS, et al. (2000). Minor phenolics from Crinum bulbispermum bulbs. Phytochemistry,2000,54(8),891-896. [View] [PubMed]
Pubchem: 15549895
Nmrshiftdb2: 70009212

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)ccc(c2)-c3ccccc3

Level: 1

Mol. Weight: 242.23 g/mol

Structure

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 242.23 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 242.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.71
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.54
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.76

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.74
Plasma Protein Binding
58.9
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.99
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.73
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.31
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.92
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
4.49
Rat (Acute)
1.85
Rat (Chronic Oral)
1.66
Fathead Minnow
4.43
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
383.65
Hydration Free Energy
-9.09
Log(D) at pH=7.4
2.53
Log(P)
2.84
Log S
-3.75
Log(Vapor Pressure)
-7.64
Melting Point
186.33
pKa Acid
7.53
pKa Basic
1.77
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9763
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9763
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9633
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9633
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9459
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9459
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9409
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9409
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.9393
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.9393
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9373
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9373
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9369
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9369
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9245
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9245
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9233
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9233
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.9187
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.9187
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.9057
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.9057
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9024
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9024
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9016
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9016
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8973
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8973
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.8942
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.8942
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8879
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8879
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8834
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8834
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8820
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8820
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8814
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8814
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8800
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8800
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8750
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8750
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8717
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8717
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8699
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8699
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8615
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8615
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8562
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8562
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8553
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8553
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8449
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8449
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8423
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8423
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8389
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8389
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8371
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8371
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8352
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8352
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8350
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8350
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8315
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8315
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8301
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8301
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8267
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8267
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 3 0.8259
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 3 0.8259
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8250
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8250
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8246
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8246
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8225
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8225
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8180
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8180
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8166
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8166
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8144
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8144
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8124
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8124
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8117
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8117
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8116
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8116
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8028
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8028
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8026
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8026
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8021
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8021
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.8014
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.8014
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8009
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8009
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7997
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7997
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7988
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7988
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7956
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7956
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7951
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7951
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7951
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7951
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7949
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7949
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7936
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7936
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7923
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7923
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7907
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7907
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7905
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7905
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7893
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7893
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7888
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7888
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7881
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7881
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7856
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7856
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7849
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7849
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7801
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7801
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7784
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7784
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7778
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7778
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7768
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7768
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7748
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7748
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7745
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7745
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7743
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7743
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7706
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7706
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7705
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7705
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7699
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7699
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7697
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7697
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7685
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7685
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7683
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7683
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7680
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7680
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7659
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7659
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7654
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7654
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7649
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7649
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7644
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7644
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7639
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7639
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7631
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7631
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7582
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7582
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7581
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7581
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7576
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7576
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7574
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7574
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7551
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7551
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7535
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7535
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7533
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7533
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7532
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7532
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7521
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7521
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7514
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7514
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7498
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7498
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7492
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7492
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7484
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7484
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7484
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7484
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7473
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7473
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7417
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7417
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7412
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7412
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7406
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7406
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7403
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7403
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7402
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7402
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7398
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7398
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7396
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7396
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7390
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7390
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 4 0.7381
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7381
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 4 0.7381
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7381
Thymidylate kinase Q9HZN8 KTHY_PSEAE Pseudomonas aeruginosa 3 0.7380
Thymidylate kinase Q9HZN8 KTHY_PSEAE Pseudomonas aeruginosa 3 0.7380
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7378
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7378
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7363
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7363
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7358
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7358
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7352
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7352
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7348
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7348
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7337
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7337
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7337
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7337
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7326
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7326
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7323
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7323
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7317
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7317
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7315
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7315
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7315
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7315
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7309
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7309
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7307
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7307
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7302
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7302
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7292
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7292
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 2 0.7281
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7281
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 2 0.7281
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7281
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7258
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7258
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7257
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7257
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7239
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7239
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7238
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7238
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7234
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7234
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7231
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7231
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7214
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7214
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7204
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7204
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7203
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7203
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7192
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7192
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7190
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7190
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7181
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7181
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7169
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7169
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7162
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7162
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7149
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7149
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7143
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7143
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7141
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7141
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7140
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7140
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7140
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7140
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7138
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7138
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7129
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7129
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7127
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7127
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7124
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7124
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7101
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7101
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7098
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7098
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7096
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7096
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7079
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7079
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.7072
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.7072
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7067
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7067
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7065
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7065
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7059
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7059
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7057
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7057
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7051
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7051
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7048
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7048
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7048
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7048
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7039
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7039
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7033
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7033
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7023
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7023
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7020
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7020
Serine/threonine-protein kinase receptor R3 P37023 ACVL1_HUMAN Homo sapiens 3 0.7019
Serine/threonine-protein kinase receptor R3 P37023 ACVL1_HUMAN Homo sapiens 3 0.7019

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