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Hippacine

Family: Plantae - Amaryllidaceae
Kingdom: Plantae
Class: Alkaloid

Canonical Smiles	Oc1cc2c(cc1O)c1cccc3c1n(c2=O)cc3
InChI	InChI=1S/C15H9NO3/c17-12-6-10-9-3-1-2-8-4-5-16(14(8)9)15(19)11(10)7-13(12)18/h1-7,17-18H
InChIKey	KLZMKXANTDISDA-UHFFFAOYSA-N
Formula	C₁₅H₉NO₃
HBA	4
HBD	2
MW	251.24
Rotatable Bonds	0
TPSA	61.94
LogP	2.45
Number Rings	4
Number Aromatic Rings	4
Heavy Atom Count	19
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	251.06
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Crinum bulbispermum	Amaryllidaceae	Plantae	209086

Showing of synonyms

Ramadan MA, Kamel MS, et al. (2000). Minor phenolics from Crinum bulbispermum bulbs. Phytochemistry,2000,54(8),891-896. [View] [PubMed]

Pubchem: 10015025

Cas: 11013-98-2

Zinc: ZINC000014677572

Nmrshiftdb2: 60030051

No compound-protein relationship available.

SMILES: c1ccc(c2c13)c4c(c(=O)n2cc3)cccc4

Level: 0

Mol. Weight: 251.24 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.87
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.340
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.19

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.330
Plasma Protein Binding: 72.64
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.960
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.970
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.360
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 4.350
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Toxic
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Toxic
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.170
Rat (Acute): 2.420
Rat (Chronic Oral): 2.880
Fathead Minnow: 4.630
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Toxic
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 480.710
Hydration Free Energy: -10.880
Log(D) at pH=7.4: 1.390
Log(P): 1.72
Log S: -4.99
Log(Vapor Pressure): -8.25
Melting Point: 313.88
pKa Acid: 8.24
pKa Basic: 7.58

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9478
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9478
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9375
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9375
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9233
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.9233
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.9233
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9233
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9161
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9161
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	3	0.9142
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	3	0.9142
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9026
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9026
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.9022
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.9022
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.8998
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.8998
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8994
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8994
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8991
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8991
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.8981
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.8981
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8960
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8960
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8898
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8898
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8843
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8843
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8842
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8842
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8841
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8841
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8798
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8798
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8751
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8751
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	3	0.8683
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	3	0.8683
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.8667
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.8667
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8643
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8643
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.8638
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.8638
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.8638
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.8638
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8629
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8629
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8598
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8598
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8565
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8565
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8555
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8555
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8503
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8503
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	4	0.8462
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	4	0.8462
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8452
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8452
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8423
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8423
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8416
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8416
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8415
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8415
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8381
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8381
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.8378
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.8378
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8368
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8368
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8368
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8368
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8339
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8339
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8309
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8309
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8292
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8292
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8284
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8284
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8261
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8261
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8254
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8254
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8250
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8250
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8250
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8250
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8247
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8247
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.8199
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.8199
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	4	0.8195
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	4	0.8195
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	4	0.8183
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	4	0.8183
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8181
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8181
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.8173
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.8173
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8162
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8162
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.8128
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.8128
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8048
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8048
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7991
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7991
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.7984
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.7984
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7975
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7975
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7973
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7973
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7969
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7969
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7969
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7969
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7948
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7948
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7935
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7935
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7918
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7918
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7910
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7910
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7894
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7894
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7881
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7881
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7879
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7879
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.7873
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.7873
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7869
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7869
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7858
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7858
IAG-nucleoside hydrolase	Q9GPQ4	Q9GPQ4_TRYVI	Trypanosoma vivax	4	0.7816
IAG-nucleoside hydrolase	Q9GPQ4	Q9GPQ4_TRYVI	Trypanosoma vivax	4	0.7816
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7798
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7798
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7791
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7791
Thyroxine-binding globulin	P05543	THBG_HUMAN	Homo sapiens	3	0.7788
Thyroxine-binding globulin	P05543	THBG_HUMAN	Homo sapiens	3	0.7788
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.7780
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.7780
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7754
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7754
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7731
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7731
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7726
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7726
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	3	0.7723
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	3	0.7723
IAG-nucleoside hydrolase	Q9GPQ4	Q9GPQ4_TRYVI	Trypanosoma vivax	4	0.7715
IAG-nucleoside hydrolase	Q9GPQ4	Q9GPQ4_TRYVI	Trypanosoma vivax	4	0.7715
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7685
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7685
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7675
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7675
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7671
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7671
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7664
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7664
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7657
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7657
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7642
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7642
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7642
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7642
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7640
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7640
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7618
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7618
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7605
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7605
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7589
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7589
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7586
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7586
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7585
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7585
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7579
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7579
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.7574
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.7574
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7568
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7568
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7556
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7556
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7553
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7553
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7551
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7551
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7544
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7544
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase	Q6T1W8	FDTA_ANETH	Aneurinibacillus thermoaerophilus	3	0.7532
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase	Q6T1W8	FDTA_ANETH	Aneurinibacillus thermoaerophilus	3	0.7532
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7519
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7519
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7508
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7508
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7504
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7504
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7502
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7502
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7493
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7493
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7489
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7489
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7480
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7480
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7475
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7475
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	3	0.7470
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	3	0.7470
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7469
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7469
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7462
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7462
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7459
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7459
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7457
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7457
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7446
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7446
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7439
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7439
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7438
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7438
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7432
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7432
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7432
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7432
Tyrosine 3-monooxygenase	P04177	TY3H_RAT	Rattus norvegicus	3	0.7430
Tyrosine 3-monooxygenase	P04177	TY3H_RAT	Rattus norvegicus	3	0.7430
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	4	0.7426
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	4	0.7426
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7420
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7420
Albumin	P02768	ALBU_HUMAN	Homo sapiens	4	0.7417
Albumin	P02768	ALBU_HUMAN	Homo sapiens	4	0.7417
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.7408
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.7408
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7404
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7404
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7387
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7387
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7387
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7387
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7384
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7384
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.7376
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.7376
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7366
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7366
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7364
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7364
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7359
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7359
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7347
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7347
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7346
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7346
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7346
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7346
Sepiapterin reductase	Q64105	SPRE_MOUSE	Mus musculus	3	0.7338
Sepiapterin reductase	Q64105	SPRE_MOUSE	Mus musculus	3	0.7338
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.7336
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.7336
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7323
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7323
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7317
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7317
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7312
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7312
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7307
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7307
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7291
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7291
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	4	0.7290
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	4	0.7290
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7290
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7290
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7289
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7289
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7283
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7283
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7277
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7277
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7276
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7276
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.7270
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.7270
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.7259
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.7259
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7257
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7257
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7252
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7252
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7248
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7248
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7247
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7247
Beta-glucosidase	Q8T0W7	Q8T0W7_9NEOP	Neotermes koshunensis	3	0.7243
Beta-glucosidase	Q8T0W7	Q8T0W7_9NEOP	Neotermes koshunensis	3	0.7243
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7237
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7237
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7229
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7229
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7228
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7228
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	4	0.7225
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	4	0.7225
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7224
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7224
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7213
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7213
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7209
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7209
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7206
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7206
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7197
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7197
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7190
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7190
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7189
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7189
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7187
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7187
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7186
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7186
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7181
Glutathione S-transferase	Q8ILQ7	GST_PLAFA	Plasmodium falciparum	3	0.7181
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7181
Glutathione S-transferase	Q8ILQ7	GST_PLAFA	Plasmodium falciparum	3	0.7181
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7169
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7169
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	4	0.7166
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	4	0.7166
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.7162
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.7162
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.7161
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.7161
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7157
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7157
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7151
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7151
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7147
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7147
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7139
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7139
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7112
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7112
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7105
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7105
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7104
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7104
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7099
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7099
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7090
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7090
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7086
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7086
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7084
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7084
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7082
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7082
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7063
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7063
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7054
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7054
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7050
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7050
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7042
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7042
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7039
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7039
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7036
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7036
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7032
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7032
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7028
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7028
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7022
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7022
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7020
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7020
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	4	0.7015
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	4	0.7015
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7008
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7008
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7007
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7007

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