4'-hydroxy-7-methoxy-flavan-3-ol - Compound Card

4'-hydroxy-7-methoxy-flavan-3-ol

Select a section from the left sidebar

4'-hydroxy-7-methoxy-flavan-3-ol

Structure
Zoomed Structure
  • Family: Amaryllidaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanol
Canonical Smiles COc1ccc2c(c1)O[C@@H]([C@H](C2)O)c1ccc(cc1)O
InChI InChI=1S/C16H16O4/c1-19-13-7-4-11-8-14(18)16(20-15(11)9-13)10-2-5-12(17)6-3-10/h2-7,9,14,16-18H,8H2,1H3/t14-,16+/m0/s1
InChIKey XPHACJZIOXWENC-GOEBONIOSA-N
Formula C16H16O4
HBA 4
HBD 2
MW 272.3
Rotatable Bonds 2
TPSA 58.92
LogP 2.44
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 272.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Crinum bulbispermum Amaryllidaceae Plantae 209086

Showing of synonyms

  • Ramadan MA, Kamel MS, et al. (2000). Minor phenolics from Crinum bulbispermum bulbs. Phytochemistry,2000,54(8),891-896. [View] [PubMed]
Pubchem: 15549896
Chebi: 180151
Nmrshiftdb2: 70009210

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2)c3ccccc3

Level: 1

Mol. Weight: 210.28 g/mol

Structure

SMILES: C1CCOc(c12)cccc2

Level: 0

Mol. Weight: 134.18 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.71
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.500
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.1

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.940
Plasma Protein Binding
77.81
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.860
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.580
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.040
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.790
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.470
Rat (Acute)
1.900
Rat (Chronic Oral)
2.210
Fathead Minnow
4.210
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
386.990
Hydration Free Energy
-10.890
Log(D) at pH=7.4
2.940
Log(P)
2.63
Log S
-3.11
Log(Vapor Pressure)
-7.02
Melting Point
147.64
pKa Acid
10.21
pKa Basic
3.01
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9785
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9785
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9696
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9696
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9604
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9604
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9536
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9536
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9489
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9489
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9476
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9476
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9452
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9452
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9391
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9391
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9386
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9386
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9357
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9357
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9255
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9255
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.9217
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.9217
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9200
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9200
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9137
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.9137
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.9137
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9137
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9131
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9131
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.9128
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.9128
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9098
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9098
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9014
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9014
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9013
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9013
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8955
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8955
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8955
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8955
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8919
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8919
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8883
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8883
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8848
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8848
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8811
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8811
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8783
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8783
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8773
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8773
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8771
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8771
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8712
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8712
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8690
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8690
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8685
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8685
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8672
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8672
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8667
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8667
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8664
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8664
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8627
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8627
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8603
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8603
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8590
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8590
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8572
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8572
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8532
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8532
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8501
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8501
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8492
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8492
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8471
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8471
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8466
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8466
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8459
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8459
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8368
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8368
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8365
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8365
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8314
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8314
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8312
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8312
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8305
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8305
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8297
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8297
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8235
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8235
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8232
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8232
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8213
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8213
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8202
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8202
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8175
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8175
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8158
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8158
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8135
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8135
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8063
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8063
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8037
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8037
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.8016
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8016
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8016
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.8016
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.8012
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.8012
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7992
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7992
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7968
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7968
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7960
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7960
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7947
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7947
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7944
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7944
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7940
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7940
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7909
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7909
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.7906
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.7906
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7900
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7900
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7895
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7895
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7884
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7884
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7867
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7867
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7864
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7864
Aldo-keto reductase family 1 member C21 Q91WR5 AK1CL_MOUSE Mus musculus 4 0.7856
Aldo-keto reductase family 1 member C21 Q91WR5 AK1CL_MOUSE Mus musculus 4 0.7856
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7850
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7850
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7850
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7850
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7835
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7835
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7824
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7824
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7816
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7816
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7814
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7814
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7814
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7814
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7807
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7807
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7805
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7805
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7803
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7803
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7800
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7800
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.7792
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.7792
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7790
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7790
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7776
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7776
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7735
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7735
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7729
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7729
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7726
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7726
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7726
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7726
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7724
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7724
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7721
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7721
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7713
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7713
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7711
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7711
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7658
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7658
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7634
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7634
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7634
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7634
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7633
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7633
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7631
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7631
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7630
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7630
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7624
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7624
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7618
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7618
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7615
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7615
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7603
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7603
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7601
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7601
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7596
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7596
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7590
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7590
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7588
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7588
Lanosterol 14-alpha demethylase A6ZSR0 A6ZSR0_YEAS7 Saccharomyces cerevisiae 3 0.7586
Lanosterol 14-alpha demethylase A6ZSR0 A6ZSR0_YEAS7 Saccharomyces cerevisiae 3 0.7586
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7585
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7585
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7571
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7571
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7568
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7568
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7564
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7564
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7557
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7557
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7553
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7553
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7551
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7551
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7551
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7551
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7550
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7550
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7540
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7540
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7527
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7527
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7518
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7518
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.7509
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.7509
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7505
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7505
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7486
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7486
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7485
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7485
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7482
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7482
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 4 0.7471
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 4 0.7471
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7465
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7465
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7461
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7461
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7461
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7461
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7458
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7458
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7452
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7452
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7446
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7446
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7431
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7431
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7423
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7423
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7418
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7418
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7417
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7417
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7416
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7416
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7416
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7416
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7410
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7410
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7405
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7405
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7395
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7395
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7389
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7389
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7389
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7389
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7377
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7377
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7373
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7373
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7373
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7373
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7359
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7359
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7355
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7355
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.7353
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.7353
Dihydrofolate reductase Q6FPH0 Q6FPH0_CANGA Candida glabrata 4 0.7348
Dihydrofolate reductase Q6FPH0 Q6FPH0_CANGA Candida glabrata 4 0.7348
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7345
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7345
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7344
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7344
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7340
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7340
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7338
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7338
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7325
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7325
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7325
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7325
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7318
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7318
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7314
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7314
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7310
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7310
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7301
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7301
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7296
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7296
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7292
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7292
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7284
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7284
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7279
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7279
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7277
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7277
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7276
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7276
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7271
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7271
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7268
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7268
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7266
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7266
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7265
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7265
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7261
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7261
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7261
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7261
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7251
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7251
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7246
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7246
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7243
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7243
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7243
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7243
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7243
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7243
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7241
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7241
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7239
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7239
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7238
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7238
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7223
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7223
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 3 0.7217
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 3 0.7217
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7202
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7202
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7196
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7196
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7196
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7196
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.7192
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.7192
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7191
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7191
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7190
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7190
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7184
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7184
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7183
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7183
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7172
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7172
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7168
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7168
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7167
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7167
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7161
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7161
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7155
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7155
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7150
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7150
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7150
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7150
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7150
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7150
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7148
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7148
RNA-directed RNA polymerase lambda-3 P0CK31 RDRP_REOVD Reovirus type 3 3 0.7144
RNA-directed RNA polymerase lambda-3 P0CK31 RDRP_REOVD Reovirus type 3 3 0.7144
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7144
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7144
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7141
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7141
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7138
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7138
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7137
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7137
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7136
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7136
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7132
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7132
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7131
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7131
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7131
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7131
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7130
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7130
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7126
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7126
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 3 0.7124
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 4 0.7124
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 4 0.7124
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 3 0.7124
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7120
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7120
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7119
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7119
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7117
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7117
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7103
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7103
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7101
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7101
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7093
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7093
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7086
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7086
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7082
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7082
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7082
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7082
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7066
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7066
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7064
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7064
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7060
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7060
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7051
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7051
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7046
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7046
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7046
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7046
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7043
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7043
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7042
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7042
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7042
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7042
Serine/threonine-protein kinase 25 O00506 STK25_HUMAN Homo sapiens 4 0.7041
Serine/threonine-protein kinase 25 O00506 STK25_HUMAN Homo sapiens 4 0.7041
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7039
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7039
Granule-bound starch synthase 1, chloroplastic/amyloplastic Q0DEV5 SSG1_ORYSJ Oryza sativa subsp. japonica 3 0.7034
Granule-bound starch synthase 1, chloroplastic/amyloplastic Q0DEV5 SSG1_ORYSJ Oryza sativa subsp. japonica 3 0.7034
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7033
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7033
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7029
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7029
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7027
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7027
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7027
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7027
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7023
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7023
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7017
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7017
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7016
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7016
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7014
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7014
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7005
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7005
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7003
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7003

Download SDF