Liquiritigenin - Compound Card

Liquiritigenin

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Liquiritigenin

Structure
Zoomed Structure
  • Family: Plantae - Amaryllidaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O1)cc(cc2)O
InChI InChI=1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
InChIKey FURUXTVZLHCCNA-AWEZNQCLSA-N
Formula C15H12O4
HBA 4
HBD 2
MW 256.26
Rotatable Bonds 1
TPSA 66.76
LogP 2.8
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 256.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Crinum bulbispermum Amaryllidaceae Plantae 209086
2 Pancratium maritimum Amaryllidaceae Plantae 644807

Showing of synonyms

  • Youssef DTA, Ramadan MA and Khalifa AA. (1998). Acetophenones, a chalcone, a chromone and flavonoids from Pancratium maritimum. Phytochemistry,1998,49(8),2579-2583. [View]
  • Ramadan MA, Kamel MS, et al. (2000). Minor phenolics from Crinum bulbispermum bulbs. Phytochemistry,2000,54(8),891-896. [View] [PubMed]
Pubchem: 114829
Kegg Ligand: C09762
Chebi: 28777
Nmrshiftdb2: 60021696
Metabolights: MTBLC28777
Drugbank: DB03601
Pdb Ligand: DFV
Bindingdb: 50241408
CPRiL: 59177
Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 256.26 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 256.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 256.26 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.76
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.680
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.8

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.990
Plasma Protein Binding
81.07
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.040
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.940
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.940
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
4.410
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.310
Rat (Acute)
1.720
Rat (Chronic Oral)
2.320
Fathead Minnow
4.290
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
398.800
Hydration Free Energy
-9.910
Log(D) at pH=7.4
2.300
Log(P)
2.33
Log S
-3.85
Log(Vapor Pressure)
-8.01
Melting Point
243.25
pKa Acid
8.12
pKa Basic
6.35
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9872
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9872
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9833
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9833
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9769
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9769
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9766
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9766
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9710
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9710
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9704
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9704
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9694
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9694
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9650
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9650
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9646
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9646
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9626
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9626
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9599
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9599
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9583
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9583
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9550
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9550
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9543
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9543
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9516
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9516
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9498
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9498
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9497
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9497
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9463
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9463
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9427
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9427
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9414
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9414
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.9409
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.9409
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9383
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9383
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9379
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9379
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9366
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9366
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9353
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9353
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9347
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9347
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9302
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9302
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9270
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9270
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9258
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9258
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9255
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9255
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9194
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9194
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.9145
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.9145
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9138
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9138
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9123
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9123
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9118
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9118
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.9093
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.9093
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.9079
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.9079
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9068
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9068
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9021
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9021
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9013
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9013
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8989
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8989
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8952
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8952
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8950
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8950
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8899
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8899
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8891
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8891
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8872
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8872
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8859
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8859
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8826
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8826
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8760
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8760
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8751
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8751
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8751
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8751
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8731
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8731
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8682
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8682
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8675
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8675
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8674
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8674
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8663
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8663
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8645
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8645
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8608
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8608
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8598
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8598
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8597
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8597
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8595
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8595
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8593
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8593
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8592
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8592
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8583
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8583
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8575
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8575
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8545
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8545
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8528
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8528
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8520
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8520
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8489
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8489
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8485
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8485
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8454
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8454
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8448
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8448
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8434
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8434
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8418
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8418
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8400
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8400
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8398
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8398
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8369
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8369
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8363
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8363
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8347
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8347
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8343
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8343
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8321
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8321
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8317
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8317
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8309
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8309
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8303
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8303
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8272
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8272
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8271
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8271
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8248
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8248
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8247
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8247
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8243
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8243
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8238
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8238
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8228
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8228
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8205
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8205
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8204
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8204
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8204
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8204
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8196
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8196
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8181
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8181
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8168
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8168
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8157
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8157
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8157
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8157
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8149
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8149
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8127
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8127
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8122
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8122
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8115
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8115
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8101
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8101
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8095
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8095
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8092
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8092
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8084
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8084
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8078
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8078
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8073
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8073
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8050
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8050
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.8035
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.8035
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8030
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8030
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7947
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7947
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7946
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7946
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7946
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7946
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7930
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7930
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7929
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7929
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7922
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7922
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7893
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7893
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7891
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7891
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7889
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7889
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7879
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7879
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7877
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7877
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7858
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7858
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7843
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7843
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7804
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7804
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7797
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7797
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7792
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7792
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7789
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7789
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7789
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7789
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7787
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7787
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7783
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7783
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 4 0.7741
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 4 0.7741
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7739
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7739
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7719
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7719
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7702
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7702
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7701
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7701
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7696
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7696
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7684
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7684
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7683
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7683
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7683
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7683
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7681
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7681
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7676
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7676
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7662
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7662
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7654
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7654
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7651
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7651
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7650
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7650
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7647
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7647
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7646
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7646
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7633
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7633
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7626
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7626
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7619
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7619
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7619
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7619
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7615
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7615
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7614
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7614
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7592
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7592
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7585
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7585
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7579
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7579
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7578
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7578
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7574
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7574
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7558
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7558
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7557
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7557
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7546
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7546
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7540
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7540
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7536
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7536
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7528
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7528
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7523
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7523
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7514
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7514
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7514
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7514
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7504
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7504
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7493
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7493
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7493
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7493
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7491
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7491
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7490
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7490
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7483
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7483
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7480
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7480
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7474
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7474
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7459
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7459
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7455
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7455
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7437
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7437
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7432
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7432
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7429
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7429
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7427
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7427
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7425
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7425
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7409
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7409
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7398
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7398
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7398
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7398
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7394
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7394
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7394
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7394
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7387
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7387
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7386
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7386
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7378
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7378
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7377
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7377
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7371
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7371
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7368
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7368
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7365
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7365
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.7361
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.7361
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7360
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7360
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7359
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7359
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7351
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7351
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7351
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7351
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7350
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7350
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7349
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7349
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7348
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7348
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7341
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7341
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7339
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7339
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7338
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7338
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7336
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7336
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7335
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7335
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7332
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7332
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7328
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7328
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 4 0.7324
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7324
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7324
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 4 0.7324
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7319
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7319
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7316
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7316
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7307
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7307
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7301
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7301
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7300
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7300
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7296
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7296
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7285
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7285
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7283
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7283
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7281
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7281
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 3 0.7280
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 3 0.7280
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7275
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7275
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7273
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7273
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7256
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7256
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7255
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7255
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7245
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7245
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7245
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7245
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7230
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7230
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7229
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7229
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7228
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7228
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7225
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7225
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7224
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7224
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7218
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7218
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7205
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7205
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7202
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7202
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7200
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7200
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7198
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7198
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7189
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7189
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7188
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7188
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7179
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7179
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7175
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7175
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7173
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7173
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7173
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7173
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7171
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7171
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7169
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7169
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7158
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7158
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7155
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7155
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7152
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7152
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7148
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7148
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7144
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7144
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7136
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7136
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7130
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7130
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7130
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7130
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7130
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7130
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7130
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7130
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7126
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7126
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7124
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7124
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7120
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7120
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7111
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7111
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7108
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7108
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7104
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7104
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7102
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7102
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7099
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7099
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7097
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7097
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7091
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7091
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7088
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7088
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7087
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7087
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7082
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7082
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7074
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7074
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7073
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7073
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 2 0.7067
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 2 0.7067
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7065
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7065
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7063
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7063
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7055
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7055
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7054
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7054
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7048
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7048
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7047
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7047
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7047
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7047
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7046
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7046
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7044
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7044
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7036
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7036
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7033
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7033
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7032
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7032
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7021
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7021
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7020
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7020
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7017
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7017
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7014
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7014
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7012
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7012
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7011
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7009
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7009
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7009
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7009
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7009
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7009
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 4 0.7007
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 4 0.7007
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7004
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7004

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