5,7-dihydroxy-2-methylchromone - Compound Card

5,7-dihydroxy-2-methylchromone

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5,7-dihydroxy-2-methylchromone

Structure
Zoomed Structure
  • Family: Plantae - Rubiaceae
  • Kingdom: Plantae
  • Class: Phenolic
    • Subclass: Benzopyran
Canonical Smiles Oc1cc(O)c2c(c1)oc(cc2=O)C
InChI InChI=1S/C10H8O4/c1-5-2-7(12)10-8(13)3-6(11)4-9(10)14-5/h2-4,11,13H,1H3
InChIKey NCUJRUDLFCGVOE-UHFFFAOYSA-N
Formula C10H8O4
HBA 4
HBD 2
MW 192.17
Rotatable Bonds 0
TPSA 70.67
LogP 1.51
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 14
Formal Charge 0
Fraction CSP3 0.1
Exact Mass 192.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Pancratium maritimum Amaryllidaceae Plantae 644807
2 Schumanniophyton magnificum Rubiaceae Plantae 114490

Showing of synonyms

  • Ali AA, Makboul MA, et al. (1990). Chromones and flavans from Pancratzum maritimum. Phytochemistry,1990,29(2),625-627. [View]
  • Okogun JI, Adeboye JO, et al. (1983). Novel structures of two chromone alkaloids from root-bark of Schumanniophyton magnificum. Planta Medica, 1983, 49(10), 95-98. [View]
Pubchem: 5375252
Chebi: 67375
Nmrshiftdb2: 60060679
Metabolights: MTBLC67375
CPRiL: 427897
Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 192.17 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.83
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.52
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.03

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.86
Plasma Protein Binding
59.71
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.6
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.73
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.72
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
4.31
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.45
Rat (Acute)
2.12
Rat (Chronic Oral)
2.78
Fathead Minnow
3.98
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
361.45
Hydration Free Energy
-12.4
Log(D) at pH=7.4
1.84
Log(P)
2.11
Log S
-3.36
Log(Vapor Pressure)
-5.33
Melting Point
246.99
pKa Acid
8.59
pKa Basic
5.26
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9443
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9443
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.9307
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.9307
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9263
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9263
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9089
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9089
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9050
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9050
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.9004
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.9004
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8979
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8979
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8954
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8954
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.8951
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8951
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8951
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.8951
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8947
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8947
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8925
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8925
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8890
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8890
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8839
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8839
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8801
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8801
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8798
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8798
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8756
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8756
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8753
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8753
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8751
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8751
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8745
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8745
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8727
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8727
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8723
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8723
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8714
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8714
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8714
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8714
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8711
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8711
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8684
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8684
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8649
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8649
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8646
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8646
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8635
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8635
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8623
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8623
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8609
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8609
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8544
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8544
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8531
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8531
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8486
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8486
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8485
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8485
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8458
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8458
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8432
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8432
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8402
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8402
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8389
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8389
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8362
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8362
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8320
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8320
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8300
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8300
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8275
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8275
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8255
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8255
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8248
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8248
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8237
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8237
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8224
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8224
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.8205
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.8205
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.8175
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.8175
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8157
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8157
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8124
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8124
Chitinase Q54276 Q54276_SERMA Serratia marcescens 4 0.8120
Chitinase Q54276 Q54276_SERMA Serratia marcescens 4 0.8120
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8088
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8088
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8076
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8076
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8067
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8067
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8000
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8000
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7981
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7981
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7973
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7973
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7971
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7971
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7940
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7940
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7931
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7931
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7921
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7921
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7894
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7894
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7882
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7882
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7851
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7851
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7851
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7851
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7850
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7850
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7832
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7832
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7821
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7821
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7806
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7806
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7797
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7797
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7755
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7755
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7739
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7739
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7723
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7723
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7697
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7697
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7689
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7689
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7684
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7684
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7678
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7678
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7668
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7668
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7658
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7658
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7630
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7630
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7629
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7629
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7612
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7612
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7598
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7598
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7596
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7596
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7588
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7588
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7582
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7582
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7558
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7558
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7517
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7517
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7509
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7509
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7437
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7437
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7437
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7437
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7435
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7435
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7434
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7434
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7416
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7416
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7413
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7413
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7393
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7393
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7389
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7389
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7388
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7388
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7374
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7374
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7366
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7366
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7354
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7354
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7345
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7345
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 3 0.7343
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 3 0.7343
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7318
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7318
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7312
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7312
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7311
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7311
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7305
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7305
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7296
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7296
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7290
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7290
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7287
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7287
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7270
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7270
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7269
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7269
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7261
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7261
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7260
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7260
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7248
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7248
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7248
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7248
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7240
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7240
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7239
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7239
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7239
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7239
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7233
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7233
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7225
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7225
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7221
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7221
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7215
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7215
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7203
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7203
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7203
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7203
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7193
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7193
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7180
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7180
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7173
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7173
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7171
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7171
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7165
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7165
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7163
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7163
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7153
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7153
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7137
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7137
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7128
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7128
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 4 0.7123
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 4 0.7123
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7118
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7118
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7117
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7117
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7116
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7116
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7105
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7105
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7105
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7105
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7090
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7090
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7077
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7077
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7073
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7073
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7065
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7065
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7064
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7064
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7059
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7059
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7048
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7048
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7047
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7047
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7046
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7046
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7039
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7039
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7033
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7033
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7032
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7032
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7021
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7021
Raucaffricine-O-beta-D-glucosidase Q9SPP9 RG1_RAUSE Rauvolfia serpentina 3 0.7020
Raucaffricine-O-beta-D-glucosidase Q9SPP9 RG1_RAUSE Rauvolfia serpentina 3 0.7020
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7007
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7007
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7005
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7005
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7003
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7003
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7002
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7002

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