2',4,4'-trihydroxy-3'-methoxychalcone - Compound Card

2',4,4'-trihydroxy-3'-methoxychalcone

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2',4,4'-trihydroxy-3'-methoxychalcone

Structure
Zoomed Structure
  • Family: Plantae - Amaryllidaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Chalcone
Canonical Smiles COc1c(O)ccc(c1O)C(=O)/C=C/c1ccc(cc1)O
InChI InChI=1S/C16H14O5/c1-21-16-14(19)9-7-12(15(16)20)13(18)8-4-10-2-5-11(17)6-3-10/h2-9,17,19-20H,1H3/b8-4+
InChIKey ZFZIDBSKEIJNRS-XBXARRHUSA-N
Formula C16H14O5
HBA 5
HBD 3
MW 286.28
Rotatable Bonds 4
TPSA 86.99
LogP 2.71
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 286.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Crinum augustum Amaryllidaceae Plantae 16055

Showing of synonyms

  • El-Hafiz MAA, Ramadan MA and Anton R. (1990). Minor phenolic constituents of Crinum augustum. Journal of Natural Products,1990,53(5),1349-1352. [View]
Pubchem: 6439187
Chebi: 178326
Nmrshiftdb2: 70023639

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 286.28 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 286.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.61
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.740
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.88

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.020
Plasma Protein Binding
65.66
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.980
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.450
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.390
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.600
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.800
Rat (Acute)
2.270
Rat (Chronic Oral)
3.090
Fathead Minnow
4.490
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
413.700
Hydration Free Energy
-10.820
Log(D) at pH=7.4
2.670
Log(P)
2.72
Log S
-5.05
Log(Vapor Pressure)
-6.54
Melting Point
177.52
pKa Acid
6.82
pKa Basic
4.39
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9485
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9485
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9444
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9444
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9431
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9431
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9356
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9356
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9315
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9315
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9292
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9292
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.9289
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.9289
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9273
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9273
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9254
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9254
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9224
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9224
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9208
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9208
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9195
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9195
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9186
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9186
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9178
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9178
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9157
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9157
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9152
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9152
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9148
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9148
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9082
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9082
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9072
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9072
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9064
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9064
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 3 0.9005
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 3 0.9005
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8998
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8998
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.8993
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.8993
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8944
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8944
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8930
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8930
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8897
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8897
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8876
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8876
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8871
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8871
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8840
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8840
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8794
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8794
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8785
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8785
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8776
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8776
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 3 0.8747
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 3 0.8747
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8725
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8725
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8713
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8713
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8632
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8632
BH2602 protein Q9K9P3 Q9K9P3_BACHD Bacillus halodurans 3 0.8619
BH2602 protein Q9K9P3 Q9K9P3_BACHD Bacillus halodurans 3 0.8619
3-hydroxy-3-methylglutaryl-coenzyme A reductase P13702 MVAA_PSEMV Pseudomonas mevalonii 3 0.8612
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.8612
3-hydroxy-3-methylglutaryl-coenzyme A reductase P13702 MVAA_PSEMV Pseudomonas mevalonii 3 0.8612
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.8612
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8598
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8598
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.8550
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.8550
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8519
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8519
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8502
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8502
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8499
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8499
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8394
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8394
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8380
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8380
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8355
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8355
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8349
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8349
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8335
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8335
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8310
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8310
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8307
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8307
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8301
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8301
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8286
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8286
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 3 0.8278
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 3 0.8278
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8218
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8218
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.8180
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.8180
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.8173
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.8173
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8160
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8160
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8153
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8153
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8142
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8142
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8123
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8123
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8111
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8111
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8109
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8109
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8106
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8106
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8081
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8081
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8078
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8078
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8071
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8071
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8068
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8068
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8053
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8053
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8036
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8036
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8023
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8023
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8021
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8021
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7987
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7987
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7956
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7956
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7956
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7956
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7935
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7935
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7934
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7934
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7917
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7917
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7887
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7887
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7885
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7885
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7884
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7884
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7881
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7881
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.7880
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.7880
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7864
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7864
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7843
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7843
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7840
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7840
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7831
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7831
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7797
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7797
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7783
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7783
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 3 0.7781
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 3 0.7781
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7758
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7758
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7743
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7743
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7740
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7740
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7722
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7722
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7722
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7722
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7717
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7717
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7712
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7712
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7710
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7710
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7706
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7706
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7703
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7703
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7701
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7701
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7681
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7681
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7660
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7660
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7654
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7654
tRNA(His) guanylyltransferase Q5AFK5 Q5AFK5_CANAL Candida albicans 3 0.7637
tRNA(His) guanylyltransferase Q5AFK5 Q5AFK5_CANAL Candida albicans 3 0.7637
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7624
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7624
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7620
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7620
Tyrosyl-DNA phosphodiesterase 2 Q9JJX7 TYDP2_MOUSE Mus musculus 3 0.7591
Tyrosyl-DNA phosphodiesterase 2 Q9JJX7 TYDP2_MOUSE Mus musculus 3 0.7591
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7588
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7588
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7586
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7586
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7578
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7578
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7576
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7576
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7566
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7566
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7549
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7549
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7547
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7547
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7538
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7538
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7534
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7534
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7532
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7532
Integrin alpha-5 P08648 ITA5_HUMAN Homo sapiens 3 0.7522
Integrin alpha-5 P08648 ITA5_HUMAN Homo sapiens 3 0.7522
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7518
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7518
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7516
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7516
Eukaryotic translation initiation factor 2 subunit alpha P20459 IF2A_YEAST Saccharomyces cerevisiae 3 0.7511
Eukaryotic translation initiation factor 2 subunit alpha P20459 IF2A_YEAST Saccharomyces cerevisiae 3 0.7511
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7479
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7479
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7478
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7478
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7476
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7476
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7474
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7474
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7469
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7469
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7469
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7469
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7462
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7462
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7461
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7461
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7457
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7457
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7450
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7450
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7435
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7435
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7430
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7430
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.7425
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.7425
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7421
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7421
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7421
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7421
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7420
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7420
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7418
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7418
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7414
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7414
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7410
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7410
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7409
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7409
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7407
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7407
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7404
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7404
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7401
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7401
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7401
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7401
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7399
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7399
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7393
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7393
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7389
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7389
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7387
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7387
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7382
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7382
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7378
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7378
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7374
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7374
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7369
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7369
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7367
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7367
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7362
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7362
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7361
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7361
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7355
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7355
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7354
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7354
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7349
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7349
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7349
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7349
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7348
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7348
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7346
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7346
Putative pteridine reductase 2 Q8I814 Q8I814_TRYCR Trypanosoma cruzi 4 0.7338
Putative pteridine reductase 2 Q8I814 Q8I814_TRYCR Trypanosoma cruzi 4 0.7338
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7336
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7336
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7329
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7329
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7327
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7327
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7326
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7326
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7321
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7321
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7296
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7296
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7292
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7292
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7291
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7291
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7290
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7290
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7284
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7284
UDP-3-O-acyl-N-acetylglucosamine deacetylase O67648 LPXC_AQUAE Aquifex aeolicus 3 0.7282
UDP-3-O-acyl-N-acetylglucosamine deacetylase O67648 LPXC_AQUAE Aquifex aeolicus 3 0.7282
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7279
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7279
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7273
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7273
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7271
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7271
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7271
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7271
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7263
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7263
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7262
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7262
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7258
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7258
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7250
12-oxophytodienoate reductase 1 Q9XG54 OPR1_SOLLC Solanum lycopersicum 3 0.7250
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7250
12-oxophytodienoate reductase 1 Q9XG54 OPR1_SOLLC Solanum lycopersicum 3 0.7250
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7248
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7248
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7244
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7244
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7243
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7243
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7238
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7238
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7237
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7237
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7236
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7236
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7231
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7231
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7223
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7223
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7223
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7223
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7215
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7215
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7204
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7204
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7203
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7203
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7200
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7200
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7196
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7196
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7194
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7194
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7193
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7193
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7193
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7193
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7191
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7191
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7191
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7191
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7187
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7187
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7186
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7186
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7186
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7186
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7185
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7185
Glucose-1-phosphate thymidylyltransferase P26393 RMLA_SALTY Salmonella typhimurium 3 0.7183
Glucose-1-phosphate thymidylyltransferase P26393 RMLA_SALTY Salmonella typhimurium 3 0.7183
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7182
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7182
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7181
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7181
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7179
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7179
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7179
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7179
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7175
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7175
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7175
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7175
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7173
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7173
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7167
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7167
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7164
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7164
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 3 0.7160
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 3 0.7160
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7159
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7159
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7158
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7158
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7156
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7156
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7154
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7154
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7154
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7154
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7153
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7153
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7151
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7151
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7149
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7149
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7147
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7147
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7143
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7143
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7143
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7143
Interleukin enhancer-binding factor 2 Q9CXY6 ILF2_MOUSE Mus musculus 2 0.7134
Interleukin enhancer-binding factor 2 Q9CXY6 ILF2_MOUSE Mus musculus 2 0.7134
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7132
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7132
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7126
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7126
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7125
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7125
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7118
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7118
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7110
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7110
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7109
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7109
Guanylate kinase P9WKE9 KGUA_MYCTU Mycobacterium tuberculosis 4 0.7108
Guanylate kinase P9WKE9 KGUA_MYCTU Mycobacterium tuberculosis 4 0.7108
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 4 0.7099
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7099
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 4 0.7099
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7099
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7097
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7097
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7095
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7095
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7092
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7092
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7084
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7084
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7082
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7082
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7081
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7081
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 3 0.7080
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 3 0.7080
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7079
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7079
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7072
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7072
Salicylate synthase P9WFX1 MBTI_MYCTU Mycobacterium tuberculosis 3 0.7070
Salicylate synthase P9WFX1 MBTI_MYCTU Mycobacterium tuberculosis 3 0.7070
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7068
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7068
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7068
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7068
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7067
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7067
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7066
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7066
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7059
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7059
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7056
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7056
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7055
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7055
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7050
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7050
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7046
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7046
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7044
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7044
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7038
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7038
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7033
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7033
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7033
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7033
Antiviral protein I P10297 RIP1_PHYAM Phytolacca americana 4 0.7027
Antiviral protein I P10297 RIP1_PHYAM Phytolacca americana 4 0.7027
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7022
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7022
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7020
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7020
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7019
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7019
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7016
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7016
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 4 0.7014
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 4 0.7014
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7005
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7005
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7000
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7000

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