Pratosine - Compound Card

Pratosine

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Pratosine

Structure
Zoomed Structure
  • Family: Plantae - Amaryllidaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles COc1cc2c(cc1OC)c(=O)n1c3c2cccc3cc1
InChI InChI=1S/C17H13NO3/c1-20-14-8-12-11-5-3-4-10-6-7-18(16(10)11)17(19)13(12)9-15(14)21-2/h3-9H,1-2H3
InChIKey QCFCSXRONIUIKL-UHFFFAOYSA-N
Formula C17H13NO3
HBA 4
HBD 0
MW 279.29
Rotatable Bonds 2
TPSA 39.94
LogP 3.06
Number Rings 4
Number Aromatic Rings 4
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 279.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Crinum americanum Amaryllidaceae Plantae 164437

Showing of synonyms

  • Ali AA, El Sayed HM, et al. (1986). Oxocrinine and other alkaloids from Crinum americanum. Phytochemistry,1986,25(10),2399-2401. [View]
Pubchem: 10401363
Nmrshiftdb2: 60077305
CPRiL: 330053
Structure

SMILES: c1ccc(c2c13)c4c(c(=O)n2cc3)cccc4

Level: 0

Mol. Weight: 279.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.67
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.190
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.47

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.270
Plasma Protein Binding
80.81
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.040
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.770
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.380
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.340
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Toxic
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.460
Rat (Acute)
2.210
Rat (Chronic Oral)
2.050
Fathead Minnow
5.080
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Toxic
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
481.590
Hydration Free Energy
-10.170
Log(D) at pH=7.4
2.550
Log(P)
2.09
Log S
-5.77
Log(Vapor Pressure)
-6.12
Melting Point
207.8
pKa Acid
9.6
pKa Basic
3.48
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9569
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9569
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9528
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9528
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9462
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9462
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9452
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9452
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9386
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9386
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9365
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9365
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9362
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9362
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.9360
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.9360
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9312
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9312
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9300
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9300
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9259
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9259
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.9171
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.9171
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9106
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9106
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.9037
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.9037
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8866
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8866
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8838
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8838
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8820
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8820
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8817
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8817
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8806
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8806
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8805
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8805
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8797
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8797
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8794
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8794
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8760
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8760
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8750
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8750
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8719
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8719
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8652
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8652
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8647
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8647
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8639
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8639
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8636
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8636
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8602
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8602
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8552
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8552
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.8546
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.8546
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8453
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8453
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8439
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8439
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8422
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8422
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8374
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8374
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8327
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8327
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.8325
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.8325
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8322
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8322
Bromodomain testis-specific protein Q58F21 BRDT_HUMAN Homo sapiens 3 0.8316
Bromodomain testis-specific protein Q58F21 BRDT_HUMAN Homo sapiens 3 0.8316
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8187
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8187
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8182
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8182
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8181
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8181
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8169
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8169
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8153
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8153
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8085
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8085
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8049
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8049
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8048
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8048
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8023
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8023
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7993
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7993
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7990
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7990
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7988
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7988
Thyroxine-binding globulin P05543 THBG_HUMAN Homo sapiens 3 0.7977
Thyroxine-binding globulin P05543 THBG_HUMAN Homo sapiens 3 0.7977
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.7959
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.7959
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7952
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7952
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7951
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7951
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7879
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7879
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7873
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7873
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7854
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7854
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7848
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7848
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7834
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7834
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7823
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7823
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7815
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7815
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7786
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7786
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7769
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7769
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7759
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7759
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7716
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7716
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7711
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7711
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7707
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7707
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7697
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7697
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7682
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7682
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7678
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7678
Albumin P02768 ALBU_HUMAN Homo sapiens 4 0.7659
Albumin P02768 ALBU_HUMAN Homo sapiens 4 0.7659
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.7645
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.7645
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7641
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7641
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7632
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7632
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7586
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7586
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7583
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7583
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 3 0.7572
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 3 0.7572
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7562
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7562
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7556
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7556
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7553
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7553
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7552
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7552
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7549
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7549
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7538
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7538
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7507
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7507
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7500
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7500
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7484
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7484
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7472
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7472
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7470
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7470
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7456
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7456
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7444
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7444
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7439
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7439
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7430
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7430
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7414
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7414
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7410
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7410
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7408
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7408
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7399
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7399
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7399
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7399
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7373
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7373
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7362
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7362
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7360
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7360
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7359
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7359
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7351
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7351
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7311
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7311
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7309
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7309
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 4 0.7302
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 4 0.7302
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7300
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7300
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7292
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7292
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7289
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7289
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7288
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7288
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7287
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7287
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7273
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7273
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7263
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7263
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7254
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7254
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7252
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7252
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7244
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7244
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7240
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7240
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7238
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7238
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7238
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7238
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7237
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7237
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7235
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7235
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7226
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7226
Mitogen-activated protein kinase kinase kinase 14 Q99558 M3K14_HUMAN Homo sapiens 3 0.7213
Mitogen-activated protein kinase kinase kinase 14 Q99558 M3K14_HUMAN Homo sapiens 3 0.7213
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7208
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7208
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7206
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7206
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7205
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7205
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7203
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7203
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7201
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7201
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7194
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7194
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7193
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7193
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7186
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7186
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7186
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7186
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7183
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7183
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7180
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7180
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7172
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7172
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7151
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7151
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 4 0.7148
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 4 0.7148
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7143
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7143
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7127
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7127
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7114
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7114
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7100
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7100
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7093
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7093
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7092
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7092
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7090
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7090
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7086
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7086
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7082
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7082
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7079
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7079
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7075
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7075
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 4 0.7070
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 4 0.7070
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7067
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7067
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7062
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7062
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7060
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7060
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7060
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7060
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7053
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7053
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7046
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7046
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7045
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7045
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7043
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7043
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7035
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7035
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7035
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7035
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7034
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7034
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7032
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7032
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7026
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7026
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7022
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7022
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7021
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7021
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7018
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7018
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7007
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7007

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