6-(3,4-dihydroxyphenyl)-4- hydroxyhexa-3,5-dien-2-one - Compound Card

6-(3,4-dihydroxyphenyl)-4- hydroxyhexa-3,5-dien-2-one

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6-(3,4-dihydroxyphenyl)-4- hydroxyhexa-3,5-dien-2-one

Structure
Zoomed Structure
  • Family: Anacardiaceae
  • Kingdom: Plantae
  • Class: Phenolic
    • Subclass: Hydroxycinnamic Acid Derivative
Canonical Smiles CC(=O)/C=C(/C=C/c1ccc(c(c1)O)O)\O
InChI InChI=1S/C12H12O4/c1-8(13)6-10(14)4-2-9-3-5-11(15)12(16)7-9/h2-7,14-16H,1H3/b4-2+,10-6-
InChIKey QDVIEIMMEUCFMW-QXYPORFMSA-N
Formula C12H12O4
HBA 4
HBD 3
MW 220.22
Rotatable Bonds 3
TPSA 77.76
LogP 2.14
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.08
Exact Mass 220.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Pistacia atlantica Anacardiaceae Plantae 434234

Showing of synonyms

  • Yousfi M, Djeridane A, et al. (2009). Isolation and characterization of a new hispolone derivative from antioxidant extracts of Pistacia atlantica. Phytotherapy Research,2009,23(9),1237-1242. [View] [PubMed]
Pubchem: 10082188
Nmrshiftdb2: 70018869
CPRiL: 67401
Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.82
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.35
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.38

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.52
Plasma Protein Binding
41.13
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.9
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.05
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.08
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
4.69
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.94
Rat (Acute)
2.11
Rat (Chronic Oral)
2.97
Fathead Minnow
4.11
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
377.17
Hydration Free Energy
-12.2
Log(D) at pH=7.4
0.51
Log(P)
1.61
Log S
-2.64
Log(Vapor Pressure)
-6.14
Melting Point
161.24
pKa Acid
8.51
pKa Basic
4.06
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9373
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9373
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9261
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9261
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9114
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9114
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8971
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8971
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8855
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8855
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8761
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8761
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8656
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8656
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8608
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8608
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8495
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8495
Coniferyl alcohol 9-O-methyltransferase A6XNE6 A6XNE6_9ROSI Linum nodiflorum 3 0.8479
Coniferyl alcohol 9-O-methyltransferase A6XNE6 A6XNE6_9ROSI Linum nodiflorum 3 0.8479
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.8405
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.8405
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8378
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8367
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8367
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8331
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8331
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8306
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8306
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.8244
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.8244
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8244
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8244
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8208
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8208
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8133
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8133
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8034
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8034
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8029
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8029
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7990
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7990
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7963
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7963
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7924
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7924
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7890
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7890
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7883
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7883
Spermidine synthase Q8II73 Q8II73_PLAF7 Plasmodium falciparum 4 0.7878
Spermidine synthase Q8II73 Q8II73_PLAF7 Plasmodium falciparum 4 0.7878
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7874
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7874
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7861
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7861
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7853
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7853
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7786
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7786
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7773
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7773
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7745
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7745
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7744
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7744
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7738
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7738
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7738
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7738
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7710
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7710
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7702
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7702
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7694
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7694
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7692
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7692
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7687
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7687
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7654
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7654
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7642
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7642
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7637
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7637
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7637
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7637
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7633
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7633
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7631
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7631
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7625
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7625
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7602
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7602
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7558
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7558
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7553
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7553
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7543
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7543
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 4 0.7540
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 4 0.7540
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7528
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7528
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7510
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7510
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7474
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7474
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7446
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7446
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7443
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7443
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7436
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7436
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7426
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7426
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7421
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7421
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7420
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7420
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 4 0.7400
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 4 0.7400
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7393
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7393
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.7365
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.7365
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7364
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7364
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7358
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7358
Adenosine deaminase P03958 ADA_MOUSE Mus musculus 3 0.7344
Adenosine deaminase P03958 ADA_MOUSE Mus musculus 3 0.7344
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7343
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7343
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7342
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7342
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7338
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7338
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7333
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7333
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7324
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7324
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7320
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7320
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7311
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7311
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7304
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7304
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7304
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7304
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7296
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7296
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7283
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7283
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7268
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7268
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7260
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7260
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7258
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7258
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7241
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7241
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7227
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7227
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7218
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7218
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7211
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7211
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7201
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7201
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7199
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7199
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7198
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7198
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7189
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7189
cAMP-dependent protein kinase regulatory subunit P07278 KAPR_YEAST Saccharomyces cerevisiae 3 0.7185
cAMP-dependent protein kinase regulatory subunit P07278 KAPR_YEAST Saccharomyces cerevisiae 3 0.7185
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7179
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7179
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7179
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7179
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7173
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7173
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7158
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7158
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7154
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7154
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7141
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7141
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7141
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7141
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7136
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7136
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7134
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7134
Methyltransferase type 12 Q88JU2 Q88JU2_PSEPK Pseudomonas putida 3 0.7132
Methyltransferase type 12 Q88JU2 Q88JU2_PSEPK Pseudomonas putida 3 0.7132
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7117
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7117
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7109
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7109
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7104
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7104
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7102
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7102
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7102
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7102
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7102
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7102
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7100
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7100
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7097
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7097
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7095
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7095
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 3 0.7090
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 3 0.7090
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7088
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7088
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7087
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7087
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7087
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7087
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7085
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7085
16S rRNA (guanine(1405)-N(7))-methyltransferase Q7M0R2 SGM_MICZI Micromonospora zionensis 4 0.7077
16S rRNA (guanine(1405)-N(7))-methyltransferase Q7M0R2 SGM_MICZI Micromonospora zionensis 4 0.7077
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7063
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7063
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7062
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7062
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7058
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7058
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7054
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7054
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7052
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7052
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7049
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7049
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7046
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7046
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7045
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7045
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7031
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7031
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7021
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7021
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7020
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7020
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7015
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7015
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7013
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7013
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 2 0.7012
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 2 0.7012
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7010
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7010
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7006
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7006
Angiotensin-converting enzyme Q10714 ACE_DROME Drosophila melanogaster 2 0.7001
Angiotensin-converting enzyme Q10714 ACE_DROME Drosophila melanogaster 2 0.7001
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7001
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7001

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