(2S,2''S)-7,7''-di-O-methyltetrahydroamentoflavone - Compound Card

(2S,2''S)-7,7''-di-O-methyltetrahydroamentoflavone

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(2S,2''S)-7,7''-di-O-methyltetrahydroamentoflavone

Structure
Zoomed Structure
  • Family: Plantae - Anacardiaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Biflavanone
Canonical Smiles COc1cc(O)c2c(c1c1cc(ccc1O)C1CC(=O)c3c(O1)cc(cc3O)OC)OC(CC2=O)c1ccc(cc1)O
InChI InChI=1S/C32H26O10/c1-39-18-10-21(35)30-22(36)12-26(41-28(30)11-18)16-5-8-20(34)19(9-16)29-27(40-2)14-24(38)31-23(37)13-25(42-32(29)31)15-3-6-17(33)7-4-15/h3-11,14,25-26,33-35,38H,12-13H2,1-2H3
InChIKey VAXDHDRILRWGDK-UHFFFAOYSA-N
Formula C32H26O10
HBA 10
HBD 4
MW 570.55
Rotatable Bonds 5
TPSA 151.98
LogP 5.61
Number Rings 6
Number Aromatic Rings 4
Heavy Atom Count 42
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 570.15
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Rhus retinorrhoea Anacardiaceae Plantae 4012

Showing of synonyms

  • Ahmed MS, Galal AM, et al. (2001). A weakly antimalarial biflavanone from Rhus retinorrhoea. Phytochemistry,2001,58(4),599-602. [View] [PubMed]
Pubchem: 53361431

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(CC2=O)Oc(c23)c(ccc3)-c4cc(ccc4)C(CC5=O)Oc(c56)cccc6

Level: 3

Mol. Weight: 570.55 g/mol

Structure

SMILES: O=C1CCOc(c12)c(ccc2)-c3cc(ccc3)C(CC4=O)Oc(c45)cccc5

Level: 2

Mol. Weight: 570.55 g/mol

Structure

SMILES: c1ccccc1-c(ccc2)c(c23)OC(CC3=O)c4ccccc4

Level: 2

Mol. Weight: 570.55 g/mol

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 570.55 g/mol

Structure

SMILES: O=C1CCOc(c12)c(ccc2)-c3ccccc3

Level: 1

Mol. Weight: 570.55 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 570.55 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 570.55 g/mol

Antimalarial

Absorption

Caco-2 (logPapp)
-5.53
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.750
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
8.53

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.280
Plasma Protein Binding
73.2
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.260
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.930
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.800
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
8.260
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-15844.840
Rat (Acute)
2.320
Rat (Chronic Oral)
3.220
Fathead Minnow
40.400
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
454.050
Hydration Free Energy
-2.930
Log(D) at pH=7.4
4.600
Log(P)
4.25
Log S
-8.64
Log(Vapor Pressure)
-15.78
Melting Point
226.65
pKa Acid
8.27
pKa Basic
3.51
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9760
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9760
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9740
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9740
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9630
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9630
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.9482
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.9482
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9371
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9371
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9326
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9326
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9133
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9133
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9021
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9021
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8969
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8969
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8908
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8908
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.8891
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.8891
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8803
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8803
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8773
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8773
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8767
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8767
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8737
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8737
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8698
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8698
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8697
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8697
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 3 0.8637
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 3 0.8637
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8629
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8629
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8610
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8610
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8603
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8603
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8599
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8599
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8592
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8592
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8553
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8553
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 3 0.8551
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 3 0.8551
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8546
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8546
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8529
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8529
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8453
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8453
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8394
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8394
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 3 0.8381
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 3 0.8381
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8357
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8357
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8331
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8331
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8313
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8313
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8304
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8304
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8302
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8302
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.8291
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.8291
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8267
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8267
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8265
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8265
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8228
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8228
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8208
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8208
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8191
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8191
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8184
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8184
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8156
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8156
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.8125
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.8125
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8120
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8120
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8109
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8109
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8096
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8096
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8040
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8040
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8031
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8031
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8023
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8023
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7989
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7989
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7976
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7976
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7962
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7962
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7927
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7927
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7916
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7916
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7887
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7887
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7883
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7883
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7882
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7882
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7879
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7879
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7874
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7874
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7871
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7871
Prostaglandin reductase 1 Q14914 PTGR1_HUMAN Homo sapiens 4 0.7830
Prostaglandin reductase 1 Q14914 PTGR1_HUMAN Homo sapiens 4 0.7830
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7824
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7824
Bromodomain-containing protein 9 Q9H8M2 BRD9_HUMAN Homo sapiens 3 0.7805
Bromodomain-containing protein 9 Q9H8M2 BRD9_HUMAN Homo sapiens 3 0.7805
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7803
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7803
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7795
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7795
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7780
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7780
Maltose/maltodextrin-binding periplasmic protein P0AEX9 MALE_ECOLI Escherichia coli 3 0.7751
Maltose/maltodextrin-binding periplasmic protein P0AEX9 MALE_ECOLI Escherichia coli 3 0.7751
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7715
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7715
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7714
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7714
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7671
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7671
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7670
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7670
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7633
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7633
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7608
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7608
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7600
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7600
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.7597
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.7597
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7578
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7578
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7552
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7552
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7537
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7537
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7531
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7531
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7519
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7519
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7488
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7488
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7486
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7486
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7484
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7484
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 3 0.7479
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 3 0.7479
L-lactate dehydrogenase A chain P00338 LDHA_HUMAN Homo sapiens 4 0.7478
L-lactate dehydrogenase A chain P00338 LDHA_HUMAN Homo sapiens 4 0.7478
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7468
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7468
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7461
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7461
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7456
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7456
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7454
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7454
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7452
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7452
Polymerase basic protein 2 Q2LG68 Q2LG68_9INFA Influenza A virus) 5 0.7436
Polymerase basic protein 2 Q2LG68 Q2LG68_9INFA Influenza A virus) 5 0.7436
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7427
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7427
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7420
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7420
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7420
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 4 0.7420
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7420
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7420
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7420
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 4 0.7420
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7397
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7397
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.7395
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.7395
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7387
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7387
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7381
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7381
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7375
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7375
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7367
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7367
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7345
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7345
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7342
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7342
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7342
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7342
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7338
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7338
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7332
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7332
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7325
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7325
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7319
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7319
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7311
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7311
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7289
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7289
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7287
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7287
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7284
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7284
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7284
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7284
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7268
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7268
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7264
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7264
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7252
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7252
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7231
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7231
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7224
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7224
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7219
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7219
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7211
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7211
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7211
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7211
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7210
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7210
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7201
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7201
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7190
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7190
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7189
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7189
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7182
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7182
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7179
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7179
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7171
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7171
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7170
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7170
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7159
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7159
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7158
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7158
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7152
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7152
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7151
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7151
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7148
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7148
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Q5SHN1 Q5SHN1_THET8 Thermus thermophilus 3 0.7144
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Q5SHN1 Q5SHN1_THET8 Thermus thermophilus 3 0.7144
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7135
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7135
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7135
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7135
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7132
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7132
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7132
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7132
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7128
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7128
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7126
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7126
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7122
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7122
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7119
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7119
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7115
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7115
Uncharacterized protein Q55S71 Q55S71_CRYNB Cryptococcus neoformans var. neoformans serotype D 3 0.7113
Uncharacterized protein Q55S71 Q55S71_CRYNB Cryptococcus neoformans var. neoformans serotype D 3 0.7113
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7109
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7109
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7107
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7107
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7104
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7104
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7104
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7104
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7100
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7100
Avidin P02701 AVID_CHICK Gallus gallus 5 0.7089
Avidin P02701 AVID_CHICK Gallus gallus 5 0.7089
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7080
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7080
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7078
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7078
Geranylgeranyl transferase type-2 subunit alpha Q08602 PGTA_RAT Rattus norvegicus 3 0.7072
Geranylgeranyl transferase type-2 subunit alpha Q08602 PGTA_RAT Rattus norvegicus 3 0.7072
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7067
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7067
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7067
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7067
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7064
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7064
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7059
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7059
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7057
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7057
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7057
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7057
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7056
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7056
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7055
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7055
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7043
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7043
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7040
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7040
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7036
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7036
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7021
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7021
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7014
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7014
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7008
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7008
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7007
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7007
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7003
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7003

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