3,4-dihydroxybenzoic anhydride - Compound Card

3,4-dihydroxybenzoic anhydride

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3,4-dihydroxybenzoic anhydride

Structure
Zoomed Structure
  • Family: Plantae - Anacardiaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles O=C(c1ccc(c(c1)O)O)OC(=O)c1ccc(c(c1)O)O
InChI InChI=1S/C14H10O7/c15-9-3-1-7(5-11(9)17)13(19)21-14(20)8-2-4-10(16)12(18)6-8/h1-6,15-18H
InChIKey INZJGLGPSGHIGY-UHFFFAOYSA-N
Formula C14H10O7
HBA 7
HBD 4
MW 290.23
Rotatable Bonds 2
TPSA 124.29
LogP 1.51
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 290.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Mangifera indica Anacardiaceae Plantae 29780

Showing of synonyms

  • Abdel-Mageed WM, Bayoumi SAH, et al. (2014). Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity. Bioorganic and Medicinal Chemistry,2014,22(7),2236-2243. [View] [PubMed]
Pubchem: 25064624
Nmrshiftdb2: 60028521

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)OC(=O)c2ccccc2

Level: 1

Mol. Weight: 290.23 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 290.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.62
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.85
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.34

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.82
Plasma Protein Binding
57.54
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.27
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.33
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.12
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
3.91
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.34
Rat (Acute)
2.31
Rat (Chronic Oral)
3.19
Fathead Minnow
4.16
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
446.21
Hydration Free Energy
-10.91
Log(D) at pH=7.4
2.92
Log(P)
1.55
Log S
-3.62
Log(Vapor Pressure)
-6.35
Melting Point
236.91
pKa Acid
7.4
pKa Basic
3.85
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9520
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9520
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9142
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9142
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9108
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9108
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9060
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9060
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9049
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9049
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9031
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9031
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8844
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8844
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8712
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8712
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8617
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8617
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8610
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8610
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8590
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8590
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 3 0.8578
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 3 0.8578
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8549
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8549
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8510
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8510
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8504
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8504
Avidin P02701 AVID_CHICK Gallus gallus 3 0.8499
Avidin P02701 AVID_CHICK Gallus gallus 3 0.8499
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8417
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8417
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8381
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8381
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8372
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8372
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8369
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8369
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8362
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8362
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8353
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8353
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8322
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8322
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8294
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8294
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8281
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8281
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8273
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8273
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8231
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8231
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 3 0.8202
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 3 0.8202
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8154
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8154
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8068
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8068
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8052
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8052
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8045
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8045
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7983
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7983
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7977
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7977
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7847
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7847
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 3 0.7791
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 3 0.7791
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7783
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7783
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7769
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7769
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7765
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7765
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7764
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7764
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7744
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7744
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7690
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7690
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7689
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7689
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7686
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7686
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7681
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7681
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7653
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7653
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 3 0.7645
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 3 0.7645
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7622
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7622
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7614
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7614
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7593
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7593
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7578
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7578
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7543
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7543
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7530
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7530
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7516
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7516
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7505
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7505
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7500
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7500
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7495
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7495
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7484
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7484
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7479
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7479
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 3 0.7429
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 3 0.7429
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7414
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7414
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7397
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7397
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7388
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7388
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7379
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7379
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7378
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7378
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7350
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7350
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7341
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7341
Elongation factor 1-alpha O59153 EF1A_PYRHO Pyrococcus horikoshii 4 0.7337
Elongation factor 1-alpha O59153 EF1A_PYRHO Pyrococcus horikoshii 4 0.7337
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7321
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7321
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7311
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7311
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7311
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7311
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7291
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7291
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7291
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7291
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7278
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7278
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7277
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7277
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.7259
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.7259
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7257
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7257
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7233
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7233
Serine protease 1 P00760 TRY1_BOVIN Bos taurus 3 0.7228
Serine protease 1 P00760 TRY1_BOVIN Bos taurus 3 0.7228
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7225
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7225
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7208
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7208
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7201
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7201
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7196
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7196
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7192
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7192
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7191
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7191
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7174
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7174
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7174
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7174
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7161
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7161
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7160
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7160
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7156
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7156
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7150
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7150
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7146
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7146
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7133
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7133
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7128
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7128
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7122
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7122
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7119
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7119
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7113
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7113
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7098
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7098
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7097
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7097
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7092
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7092
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7090
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7090
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7089
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7089
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7086
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7086
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7082
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7082
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7075
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7075
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7065
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7065
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7062
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7062
BH2602 protein Q9K9P3 Q9K9P3_BACHD Bacillus halodurans 3 0.7060
BH2602 protein Q9K9P3 Q9K9P3_BACHD Bacillus halodurans 3 0.7060
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7053
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7053
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7049
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7049
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7046
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7046
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7042
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7042
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7029
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7029
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7028
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7028
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7024
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7024
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7023
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7023
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7016
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7016
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7005
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7005
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7002
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7002

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