P-hydroxybenzaldehyde - Compound Card

P-hydroxybenzaldehyde

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P-hydroxybenzaldehyde

Structure
Zoomed Structure
  • Family: Fungi - Trichocomaceae
  • Kingdom: Fungi, Plantae, Animalia
  • Class: Phenolic
    • Subclass: Monoaromatic
Canonical Smiles O=Cc1ccc(cc1)O
InChI InChI=1S/C7H6O2/c8-5-6-1-3-7(9)4-2-6/h1-5,9H
InChIKey RGHHSNMVTDWUBI-UHFFFAOYSA-N
Formula C7H6O2
HBA 2
HBD 1
MW 122.12
Rotatable Bonds 1
TPSA 37.3
LogP 1.2
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 9
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 122.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Anchinoe paupertas Anchinoidae Animalia —
2 Anastatica hierochuntica Cruciferae-Brassicaceea Plantae 663965
3 Pseudopestalotiopsis theae Amphisphaeriaceae Fungi 218556
4 Aspergillus falconensis Trichocomaceae Fungi 1810910

Showing of synonyms

  • Nakashima S, Matsuda H, et al. (2010). Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic and Medicinal Chemistry,2010,18(6),2337-2345. [View] [PubMed]
  • El-Kashef D.H, Youssef F.S, et al. (2021). Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies. Bioorg Med Chem,2021,29,115883. [View] [PubMed]
  • Akone SH, Wang H, et al. (2022). Prenylated cyclohexene-type meroterpenoids and sulfur-containing xanthones produced by Pseudopestalotiopsis theae. Phytochemistry, 2022, 197:113124. [View] [PubMed]
  • Bouaicha N, Amade P, et al. (1994). Zarzissine, a new cytotoxic guanidine alkaloid from the mediterranean sponge Anchinoe paupertas. Journal of Natural Products,1994,57(10),1455-1457. [View] [PubMed]
Pubchem: 126
Kegg Ligand: C00633
Chebi: 17597
Nmrshiftdb2: 10005739
Metabolights: MTBLC17597
Drugbank: DB03560
Pdb Ligand: HBA
Bindingdb: 50177411
CPRiL: 41999
Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 122.12 g/mol

Antimicrobial

Absorption

Caco-2 (logPapp)
-4.34
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.79
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.45

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.22
Plasma Protein Binding
32.68
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.01
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.28
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Toxic
Eye Irritation
Toxic
Maximum Tolerated Dose
0.98
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
4.78
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.19
Rat (Acute)
2.05
Rat (Chronic Oral)
1.89
Fathead Minnow
3.84
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
261.26
Hydration Free Energy
-8.89
Log(D) at pH=7.4
0.91
Log(P)
1.38
Log S
-1.4
Log(Vapor Pressure)
-2.4
Melting Point
123.57
pKa Acid
7.83
pKa Basic
1.27
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9699
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9699
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9680
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9680
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9646
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9646
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9590
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9590
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.9330
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.9330
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9264
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9264
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9137
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9137
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8795
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8795
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8375
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8375
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8138
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8138
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8071
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8071
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7884
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7884
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7772
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7772
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7749
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7749
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7748
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7748
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7727
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7727
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7706
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7706
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7647
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7647
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7643
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7643
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7627
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7627
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7584
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7584
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7544
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7544
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7526
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7526
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7518
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7518
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7505
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7505
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7489
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7489
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7482
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7482
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7477
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7477
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7464
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7464
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7454
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7454
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7434
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7434
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7428
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7428
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7427
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7427
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7401
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7401
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7398
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7398
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7398
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7398
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7397
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7397
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7390
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7390
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7383
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7383
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7381
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7381
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7373
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7373
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7371
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7371
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7366
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7366
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7364
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7364
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7355
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7355
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 2 0.7348
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 2 0.7348
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7319
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7319
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7313
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7313
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7311
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7311
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7310
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7310
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7305
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7305
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7300
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7300
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7298
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7298
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7297
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7297
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7297
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7297
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7297
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7297
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7294
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7294
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7288
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7288
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7288
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7288
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7286
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7286
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7282
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7282
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7279
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7279
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7269
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7269
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7250
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7250
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7249
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7249
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7244
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7244
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7243
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7243
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7235
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7235
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7226
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7226
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7220
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7220
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7220
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7220
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7214
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7214
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7209
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7209
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7209
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7209
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7201
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7201
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 2 0.7194
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 2 0.7194
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7181
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7181
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7179
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7179
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7178
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7178
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7172
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7172
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7161
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7161
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7157
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7157
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7155
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7155
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7154
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7154
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7153
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7153
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7145
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7145
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7140
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7140
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7140
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7140
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7133
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7133
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7129
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7129
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7119
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7119
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7118
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7118
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7117
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7117
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7116
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7116
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7106
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7106
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7104
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7104
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7100
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7100
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7099
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7099
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7093
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7093
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7087
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7087
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7087
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7087
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7085
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7085
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7077
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7077
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7073
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7073
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7062
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7062
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7057
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7057
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7051
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7051
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7051
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7051
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7043
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7043
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7042
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7042
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7040
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7040
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7036
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7036
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7036
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7036
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7030
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7030
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7027
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7027
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7026
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7026
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7019
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7019
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7014
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7014
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7012
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7012
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7011
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7011
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7007
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7007
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7006
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7006
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7005
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7005
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 2 0.7000
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 2 0.7000

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