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Zarzissine

Family: Animalia - Anchinoidae
Kingdom: Animalia
Class: Alkaloid
- Subclass: Guanidine Alkaloid

Canonical Smiles	Nc1nc2c([nH]1)cnnc2
InChI	InChI=1S/C5H5N5/c6-5-9-3-1-7-8-2-4(3)10-5/h1-2H,(H3,6,9,10)
InChIKey	BUYBPEINWQQOFV-UHFFFAOYSA-N
Formula	C₅H₅N₅
HBA	4
HBD	2
MW	135.13
Rotatable Bonds	0
TPSA	80.48
LogP	-0.06
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	10
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	135.05
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Anchinoe paupertas	Anchinoidae	Animalia	—

Showing of synonyms

Bouaicha N, Amade P, et al. (1994). Zarzissine, a new cytotoxic guanidine alkaloid from the mediterranean sponge Anchinoe paupertas. Journal of Natural Products,1994,57(10),1455-1457. [View] [PubMed]

Pubchem: 6400641

Cas: 160568-14-9

Zinc: ZINC000033940443

Chebi: 66501

Nmrshiftdb2: 70103046

Metabolights: MTBLC66501

Comptox: DTXSID60166939

No compound-protein relationship available.

SMILES: n1c[nH]c(c12)cnnc2

Level: 0

Mol. Weight: 135.13 g/mol

Antimicrobial

Cytotoxic

Absorption

Caco-2 (logPapp): -5.11
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.560
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.01

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.260
Plasma Protein Binding: 17.16
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.810
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: -0.160
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.390
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.060
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.090
Rat (Acute): 2.190
Rat (Chronic Oral): 2.090
Fathead Minnow: 4.920
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 386.950
Hydration Free Energy: -11.970
Log(D) at pH=7.4: -0.130
Log(P): -0.79
Log S: -1.83
Log(Vapor Pressure): -7.68
Melting Point: 287.44
pKa Acid: 8.79
pKa Basic: 5.51

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.9474
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.9474
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.9444
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.9444
S-norcoclaurine synthase	Q67A25	NCS_THLFG	Thalictrum flavum subsp. glaucum	3	0.8884
S-norcoclaurine synthase	Q67A25	NCS_THLFG	Thalictrum flavum subsp. glaucum	3	0.8884
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	3	0.8388
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	3	0.8388
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.8348
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.8348
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.8346
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.8346
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.8221
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.8221
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8081
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8081
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8076
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8076
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8073
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8073
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8000
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8000
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7853
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7853
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.7768
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.7768
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7761
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7761
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7690
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7690
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7686
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7686
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7685
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7685
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7684
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7684
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7668
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7668
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7629
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7629
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7598
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7598
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7595
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7595
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.7564
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.7564
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7526
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7526
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7478
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7478
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7468
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7468
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7433
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7433
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7427
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7427
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7420
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7420
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7380
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7380
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7375
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7375
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7361
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7361
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7361
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7361
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7356
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7356
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7304
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7304
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	2	0.7297
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	2	0.7297
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7290
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7290
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7289
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7289
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7287
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7287
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7286
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7286
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7273
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7273
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7223
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7223
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7217
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7217
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7216
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7216
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7214
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7214
Beta-galactoside alpha-2,6-sialyltransferase 1	P15907	SIAT1_HUMAN	Homo sapiens	3	0.7210
Beta-galactoside alpha-2,6-sialyltransferase 1	P15907	SIAT1_HUMAN	Homo sapiens	3	0.7210
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7209
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7209
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	P49235	HGGL1_MAIZE	Zea mays	2	0.7208
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	P49235	HGGL1_MAIZE	Zea mays	2	0.7208
Purine nucleoside phosphorylase	Q9BMI9	Q9BMI9_SCHMA	Schistosoma mansoni	3	0.7195
Purine nucleoside phosphorylase	Q9BMI9	Q9BMI9_SCHMA	Schistosoma mansoni	3	0.7195
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7194
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7194
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7187
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7187
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7174
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7174
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7171
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7171
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7163
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7163
Toluene-4-monooxygenase system, hydroxylase component subunit alpha	Q00456	TMOA_PSEME	Pseudomonas mendocina	2	0.7150
Toluene-4-monooxygenase system, hydroxylase component subunit alpha	Q00456	TMOA_PSEME	Pseudomonas mendocina	2	0.7150
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7149
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7149
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7144
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7144
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7142
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7142
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7141
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7141
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	2	0.7130
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	2	0.7130
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7120
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7120
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	2	0.7111
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	2	0.7111
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7107
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7107
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7104
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7104
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7098
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7098
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7097
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7097
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7094
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7094
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7092
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7092
Probable tRNA(His) guanylyltransferase	Q9NWX6	THG1_HUMAN	Homo sapiens	2	0.7084
Probable tRNA(His) guanylyltransferase	Q9NWX6	THG1_HUMAN	Homo sapiens	2	0.7084
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7075
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7075
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7066
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7066
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7056
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7056
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	2	0.7054
Glutamate receptor ionotropic, kainate 1	P22756	GRIK1_RAT	Rattus norvegicus	2	0.7054
Glutamate receptor ionotropic, kainate 1	P22756	GRIK1_RAT	Rattus norvegicus	2	0.7054
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	2	0.7054
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7051
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7051
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7051
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7051
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7037
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7037
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7031
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7031
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7029
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7029
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7025
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7025
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	2	0.7024
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	2	0.7024
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7020
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7020
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7006
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7006
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7000
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7000

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