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Subereamine A

Family: Animalia - Aplysinellidae
Kingdom: Animalia
Class: Alkaloid
- Subclass: Arginine-Derived Alkaloid

Canonical Smiles	COc1ccc(cc1Br)/C=C/C(=O)N[C@@H](C(=O)O)CCCNC(=N)N
InChI	InChI=1S/C16H21BrN4O4/c1-25-13-6-4-10(9-11(13)17)5-7-14(22)21-12(15(23)24)3-2-8-20-16(18)19/h4-7,9,12H,2-3,8H2,1H3,(H,21,22)(H,23,24)(H4,18,19,20)/b7-5+/t12-/m1/s1
InChIKey	CYWJABQUHPIUCD-HOSRBBHYSA-N
Formula	C₁₆H₂₁BrN₄O₄
HBA	4
HBD	5
MW	413.27
Rotatable Bonds	9
TPSA	137.53
LogP	1.3
Number Rings	1
Number Aromatic Rings	1
Heavy Atom Count	25
Formal Charge	0
Fraction CSP3	0.31
Exact Mass	412.07
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Suberea mollis	Aplysinellidae	Animalia	1161115

Showing of synonyms

Shaala LA, Bamane FH, et al. (2011). Brominated arginine-derived alkaloids from the Red Sea sponge Suberea mollis. Journal of Natural Products,2011,74(6),1517-1520. [View] [PubMed]

Pubchem: 53360350

Zinc: ZINC000072113006

Chebi: 69834

Nmrshiftdb2: 60146360

Metabolights: MTBLC69834

Chembl: CHEMBL1813810

No compound-protein relationship available.

SMILES: c1ccccc1

Level: 0

Mol. Weight: 413.27 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -6.09
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.180
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -3.43

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.510
Plasma Protein Binding: 38.28
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.790
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: -0.500
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.560
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 9.030
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -0.330
Rat (Acute): 2.280
Rat (Chronic Oral): 1.980
Fathead Minnow: 4.160
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 497.780
Hydration Free Energy: -7.650
Log(D) at pH=7.4: -0.610
Log(P): 1.28
Log S: -1.36
Log(Vapor Pressure): -12.76
Melting Point: 171.63
pKa Acid: 4.33
pKa Basic: 7.99

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.9635
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.9635
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9331
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9331
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	3	0.9296
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	3	0.9296
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9183
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9183
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.9126
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.9126
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.9028
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.9028
Aldos-2-ulose dehydratase	P84193	AUD_PHACH	Phanerodontia chrysosporium	3	0.8932
Aldos-2-ulose dehydratase	P84193	AUD_PHACH	Phanerodontia chrysosporium	3	0.8932
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8926
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8926
Nucleoside diphosphate kinase	A5J299	A5J299_PENVA	Penaeus vannamei	3	0.8898
Nucleoside diphosphate kinase	A5J299	A5J299_PENVA	Penaeus vannamei	3	0.8898
Nucleoside diphosphate kinase	O58429	NDK_PYRHO	Pyrococcus horikoshii	3	0.8865
Nucleoside diphosphate kinase	O58429	NDK_PYRHO	Pyrococcus horikoshii	3	0.8865
12-oxophytodienoate reductase 1	Q9XG54	OPR1_SOLLC	Solanum lycopersicum	3	0.8789
Hydroxymethylglutaryl-CoA synthase	Q9FD71	HMGCS_ENTFL	Enterococcus faecalis	3	0.8789
12-oxophytodienoate reductase 1	Q9XG54	OPR1_SOLLC	Solanum lycopersicum	3	0.8789
Hydroxymethylglutaryl-CoA synthase	Q9FD71	HMGCS_ENTFL	Enterococcus faecalis	3	0.8789
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	3	0.8760
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	3	0.8760
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.8709
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.8709
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR3_HUMAN	Homo sapiens	3	0.8703
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR3_HUMAN	Homo sapiens	3	0.8703
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	3	0.8613
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	3	0.8613
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8537
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8537
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.8512
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.8512
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	3	0.8428
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	3	0.8428
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8381
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8381
Laminarinase	Q9WXN1	Q9WXN1_THEMA	Thermotoga maritima	3	0.8335
Laminarinase	Q9WXN1	Q9WXN1_THEMA	Thermotoga maritima	3	0.8335
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8330
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8330
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.8240
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.8240
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8197
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8197
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.8181
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.8181
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.8157
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.8157
Aminotransferase	A8R0K5	A8R0K5_9ACTN	Streptomyces pactum	3	0.8101
Aminotransferase	A8R0K5	A8R0K5_9ACTN	Streptomyces pactum	3	0.8101
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.8040
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.8040
Serine acetyltransferase	P43886	CYSE_HAEIN	Haemophilus influenzae	3	0.7967
Serine acetyltransferase	P43886	CYSE_HAEIN	Haemophilus influenzae	3	0.7967
Aldos-2-ulose dehydratase	P84193	AUD_PHACH	Phanerodontia chrysosporium	3	0.7861
Aldos-2-ulose dehydratase	P84193	AUD_PHACH	Phanerodontia chrysosporium	3	0.7861
N-acyl homoserine lactonase AiiA	P0CJ63	AHLLA_BACTK	Bacillus thuringiensis subsp. kurstaki	3	0.7839
N-acyl homoserine lactonase AiiA	P0CJ63	AHLLA_BACTK	Bacillus thuringiensis subsp. kurstaki	3	0.7839
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7810
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7810
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7808
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7808
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7779
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7779
Synapsin-1	P09951	SYN1_RAT	Rattus norvegicus	4	0.7766
Synapsin-1	P09951	SYN1_RAT	Rattus norvegicus	4	0.7766
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7742
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7742
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7730
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7730
Cytochrome P450 monooxygenase PikC	O87605	PIKC_STRVZ	Streptomyces venezuelae	3	0.7721
Cytochrome P450 monooxygenase PikC	O87605	PIKC_STRVZ	Streptomyces venezuelae	3	0.7721
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7675
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7675
Kinesin-like protein KIF2C	Q99661	KIF2C_HUMAN	Homo sapiens	3	0.7672
Kinesin-like protein KIF2C	Q99661	KIF2C_HUMAN	Homo sapiens	3	0.7672
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7637
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7637
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7632
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7632
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7630
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7630
Ficolin-2	Q15485	FCN2_HUMAN	Homo sapiens	3	0.7629
Ficolin-2	Q15485	FCN2_HUMAN	Homo sapiens	3	0.7629
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7626
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7626
Inositol polyphosphate multikinase	P07250	IPMK_YEAST	Saccharomyces cerevisiae	4	0.7583
Inositol polyphosphate multikinase	P07250	IPMK_YEAST	Saccharomyces cerevisiae	4	0.7583
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7581
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7581
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7580
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7580
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7580
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7580
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7574
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7574
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7545
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7545
Metallophosphoesterase	A3DJ38	A3DJ38_HUNT2	Clostridium thermocellum	3	0.7537
Metallophosphoesterase	A3DJ38	A3DJ38_HUNT2	Clostridium thermocellum	3	0.7537
Receptor tyrosine-protein kinase erbB-3	P21860	ERBB3_HUMAN	Homo sapiens	4	0.7536
Receptor tyrosine-protein kinase erbB-3	P21860	ERBB3_HUMAN	Homo sapiens	4	0.7536
Uricase	Q00511	URIC_ASPFL	Aspergillus flavus	4	0.7529
Uricase	Q00511	URIC_ASPFL	Aspergillus flavus	4	0.7529
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7527
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7527
16S rRNA (guanine(1405)-N(7))-methyltransferase	Q763K9	Q763K9_ECOLX	Escherichia coli	3	0.7502
16S rRNA (guanine(1405)-N(7))-methyltransferase	Q763K9	Q763K9_ECOLX	Escherichia coli	3	0.7502
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7491
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7491
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7475
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7475
DNA polymerase I, thermostable	P19821	DPO1_THEAQ	Thermus aquaticus	4	0.7470
DNA polymerase I, thermostable	P19821	DPO1_THEAQ	Thermus aquaticus	4	0.7470
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7461
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7461
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	3	0.7448
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	3	0.7448
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7443
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7443
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7437
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7437
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7429
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7429
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	4	0.7428
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7428
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7428
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	4	0.7428
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	2	0.7415
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	2	0.7415
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7412
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7412
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7411
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7411
Flagellum-specific ATP synthase	P26465	FLII_SALTY	Salmonella typhimurium	2	0.7404
Flagellum-specific ATP synthase	P26465	FLII_SALTY	Salmonella typhimurium	2	0.7404
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7402
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7402
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7400
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7400
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7398
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7398
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7398
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7398
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7392
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7392
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7387
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7387
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7387
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7387
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7386
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7386
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7384
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7384
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7383
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7383
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7382
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7382
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7382
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7382
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7381
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7381
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7371
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7371
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7370
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7370
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7366
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7366
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7364
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7364
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7362
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7362
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7359
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7359
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.7359
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.7359
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7347
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7347
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7346
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7346
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	2	0.7345
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	2	0.7345
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7341
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7341
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7339
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7339
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7334
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7334
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7331
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7331
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7323
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7323
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7320
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7320
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7319
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7319
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7319
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7319
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7317
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7317
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	2	0.7315
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	2	0.7315
Beta-glucosidase 1A	Q25BW5	BGL1A_PHACH	Phanerodontia chrysosporium	3	0.7310
Beta-glucosidase 1A	Q25BW5	BGL1A_PHACH	Phanerodontia chrysosporium	3	0.7310
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	3	0.7308
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	3	0.7308
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7306
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7306
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	2	0.7302
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7302
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	2	0.7302
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7302
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7296
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7296
UTP-monosaccharide-1-phosphate uridylyltransferase	D3G6S4	D3G6S4_LEIMA	Leishmania major	3	0.7295
UTP-monosaccharide-1-phosphate uridylyltransferase	D3G6S4	D3G6S4_LEIMA	Leishmania major	3	0.7295
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7292
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7292
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7287
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7287
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7283
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7283
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7283
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7283
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7278
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7278
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7271
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7271
Cell division control protein 42 homolog	P60953	CDC42_HUMAN	Homo sapiens	3	0.7271
Cell division control protein 42 homolog	P60953	CDC42_HUMAN	Homo sapiens	3	0.7271
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	2	0.7253
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	2	0.7253
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7251
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7251
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7246
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7246
Ribosome-inactivating protein 3	P25891	RIP3_MAIZE	Zea mays	2	0.7242
Ribosome-inactivating protein 3	P25891	RIP3_MAIZE	Zea mays	2	0.7242
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7241
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7241
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7235
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	3	0.7235
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	2	0.7235
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7235
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	3	0.7235
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	2	0.7235
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7230
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7230
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	2	0.7229
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	2	0.7229
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7223
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7223
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7222
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7222
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7221
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7221
(R)-S-adenosyl-L-methionine hydrolase	O58212	O58212_PYRHO	Pyrococcus horikoshii OT3	3	0.7221
(R)-S-adenosyl-L-methionine hydrolase	O58212	O58212_PYRHO	Pyrococcus horikoshii OT3	3	0.7221
Mitotic checkpoint serine/threonine-protein kinase BUB1	O43683	BUB1_HUMAN	Homo sapiens	4	0.7220
Amino-acid acetyltransferase	Q5FAK7	Q5FAK7_NEIG1	Neisseria gonorrhoeae	3	0.7220
Mitotic checkpoint serine/threonine-protein kinase BUB1	O43683	BUB1_HUMAN	Homo sapiens	4	0.7220
Amino-acid acetyltransferase	Q5FAK7	Q5FAK7_NEIG1	Neisseria gonorrhoeae	3	0.7220
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7216
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7216
Insulin receptor	P06213	INSR_HUMAN	Homo sapiens	4	0.7216
Insulin receptor	P06213	INSR_HUMAN	Homo sapiens	4	0.7216
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7209
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7209
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7209
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7209
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7208
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7208
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7208
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7208
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7207
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7207
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7200
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7200
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7197
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7197
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	3	0.7184
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	3	0.7184
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	2	0.7182
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	2	0.7182
Deacetoxycephalosporin C synthase	P18548	CEFE_STRCL	Streptomyces clavuligerus	2	0.7179
Deacetoxycephalosporin C synthase	P18548	CEFE_STRCL	Streptomyces clavuligerus	2	0.7179
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.7178
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.7178
Psp operon transcriptional activator	P37344	PSPF_ECOLI	Escherichia coli	3	0.7178
Psp operon transcriptional activator	P37344	PSPF_ECOLI	Escherichia coli	3	0.7178
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7170
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7170
Nucleoside diphosphate kinase	Q381H3	Q381H3_TRYB2	Trypanosoma brucei brucei	3	0.7168
Nucleoside diphosphate kinase	Q381H3	Q381H3_TRYB2	Trypanosoma brucei brucei	3	0.7168
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7166
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7166
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	2	0.7164
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	2	0.7164
Protein kinase C iota type	Q62074	KPCI_MOUSE	Mus musculus	2	0.7162
Protein kinase C iota type	Q62074	KPCI_MOUSE	Mus musculus	2	0.7162
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7162
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7162
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7158
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7158
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7150
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7150
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7146
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7146
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	2	0.7142
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	2	0.7142
3-hydroxybenzoate 4-monooxygenase	Q6SSJ6	MOBA_COMTE	Comamonas testosteroni	2	0.7134
3-hydroxybenzoate 4-monooxygenase	Q6SSJ6	MOBA_COMTE	Comamonas testosteroni	2	0.7134
Nitrogen regulatory protein P-II	O66513	GLNB_AQUAE	Aquifex aeolicus	2	0.7131
Nitrogen regulatory protein P-II	O66513	GLNB_AQUAE	Aquifex aeolicus	2	0.7131
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7129
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7129
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7124
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7124
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	2	0.7121
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7121
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	2	0.7121
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7121
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	2	0.7119
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	2	0.7119
Eukaryotic translation initiation factor 2 subunit alpha	P20459	IF2A_YEAST	Saccharomyces cerevisiae	3	0.7113
Eukaryotic translation initiation factor 2 subunit alpha	P20459	IF2A_YEAST	Saccharomyces cerevisiae	3	0.7113
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	2	0.7108
Histidinol dehydrogenase	P06988	HISX_ECOLI	Escherichia coli	2	0.7108
Histidinol dehydrogenase	P06988	HISX_ECOLI	Escherichia coli	2	0.7108
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	2	0.7108
UDP-N-acetylmuramoylalanine--D-glutamate ligase	P14900	MURD_ECOLI	Escherichia coli	2	0.7107
UDP-N-acetylmuramoylalanine--D-glutamate ligase	P14900	MURD_ECOLI	Escherichia coli	2	0.7107
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7107
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7107
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7100
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7100
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7097
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7097
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7094
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7094
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7093
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7093
Iota toxin component Ia	Q46220	Q46220_CLOPF	Clostridium perfringens	3	0.7090
Iota toxin component Ia	Q46220	Q46220_CLOPF	Clostridium perfringens	3	0.7090
Alpha-aminoadipic semialdehyde dehydrogenase	P49419	AL7A1_HUMAN	Homo sapiens	2	0.7089
Alpha-aminoadipic semialdehyde dehydrogenase	P49419	AL7A1_HUMAN	Homo sapiens	2	0.7089
Interleukin enhancer-binding factor 2	Q9CXY6	ILF2_MOUSE	Mus musculus	2	0.7084
Interleukin enhancer-binding factor 2	Q9CXY6	ILF2_MOUSE	Mus musculus	2	0.7084
2'-5'-oligoadenylate synthase 1	P00973	OAS1_HUMAN	Homo sapiens	2	0.7078
2'-5'-oligoadenylate synthase 1	P00973	OAS1_HUMAN	Homo sapiens	2	0.7078
Ribonucleoside-diphosphate reductase large chain 1	P21524	RIR1_YEAST	Saccharomyces cerevisiae	2	0.7070
Ribonucleoside-diphosphate reductase large chain 1	P21524	RIR1_YEAST	Saccharomyces cerevisiae	2	0.7070
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7070
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7070
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7068
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7068
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7065
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7065
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	4	0.7062
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	4	0.7062
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7058
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7058
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase	P47229	BPHD_PARXL	Paraburkholderia xenovorans	2	0.7056
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P04035	HMDH_HUMAN	Homo sapiens	2	0.7056
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P04035	HMDH_HUMAN	Homo sapiens	2	0.7056
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase	P47229	BPHD_PARXL	Paraburkholderia xenovorans	2	0.7056
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7053
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7053
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7041
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7041
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7037
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7037
Mitotic checkpoint serine/threonine-protein kinase BUB1	O43683	BUB1_HUMAN	Homo sapiens	4	0.7036
Mitotic checkpoint serine/threonine-protein kinase BUB1	O43683	BUB1_HUMAN	Homo sapiens	4	0.7036
Regucalcin	Q64374	RGN_MOUSE	Mus musculus	3	0.7033
Regucalcin	Q64374	RGN_MOUSE	Mus musculus	3	0.7033
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7023
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7023
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7021
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7021
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7019
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7019
Cysteine synthase	P45040	CYSK_HAEIN	Haemophilus influenzae	3	0.7014
Cysteine synthase	P45040	CYSK_HAEIN	Haemophilus influenzae	3	0.7014
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7011
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7011
Nuclear receptor subfamily 5 group A member 2	O00482	NR5A2_HUMAN	Homo sapiens	3	0.7003
Nuclear receptor subfamily 5 group A member 2	O00482	NR5A2_HUMAN	Homo sapiens	3	0.7003
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7002
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7002

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