3- O-[beta-D-glucopyranosyl-(1→2)-beta-D-glucuronopyranosyl] hederagenin 28-O-[alpha-L-rhamnopyranosyl-(1→4)-beta-D-glucopyranosyl-(1→6)-beta-D-glucopyranosyl] ester
- Family: Plantae - Araliaceae
- Kingdom: Plantae
-
Class: Saponin
- Subclass: Oleanane-Type Saponin
Canonical Smiles | OCC1O[C@@H](OCC2O[C@@H](OC(=O)[C@@]34CCC(CC4C4=CCC5[C@@]([C@@]4(CC3)C)(C)CCC3[C@]5(C)CC[C@@H]([C@@]3(C)CO)O[C@@H]3OC(CO)[C@H](C([C@@H]3O[C@@H]3OC(CO)[C@H](C([C@@H]3O)O)O)O)O)(C)C)[C@H](C([C@@H]2O)O)O)[C@H](C([C@@H]1O[C@@H]1OC(C)[C@@H](C([C@@H]1O)O)O)O)O |
---|---|
InChI | InChI=1S/C60H98O28/c1-24-34(65)38(69)43(74)50(80-24)86-47-29(21-63)83-49(46(77)42(47)73)79-22-30-37(68)40(71)45(76)52(84-30)88-54(78)60-16-14-55(2,3)18-26(60)25-8-9-32-56(4)12-11-33(57(5,23-64)31(56)10-13-59(32,7)58(25,6)15-17-60)85-53-48(41(72)36(67)28(20-62)82-53)87-51-44(75)39(70)35(66)27(19-61)81-51/h8,24,26-53,61-77H,9-23H2,1-7H3/t24?,26?,27?,28?,29?,30?,31?,32?,33-,34-,35+,36+,37+,38?,39?,40?,41?,42?,43-,44-,45-,46-,47+,48-,49+,50-,51-,52-,53-,56-,57-,58+,59+,60-/m0/s1 |
InChIKey | KGOWBUVYTNXZLW-TVTOFXHTSA-N |
Formula | C60H98O28 |
HBA | 28 |
HBD | 17 |
MW | 1267.42 |
Rotatable Bonds | 15 |
TPSA | 453.28 |
LogP | -4.21 |
Number Rings | 10 |
Number Aromatic Rings | 0 |
Heavy Atom Count | 88 |
Formal Charge | 0 |
Fraction CSP3 | 0.95 |
Exact Mass | 1266.62 |
Number of Lipinski Rule Violations | 3 |
# | Species | Family | Kingdom | NCBI Taxonomy ID |
---|---|---|---|---|
1 | Meryta lanceolata | Araliaceae | Plantae | 310849 |
Showing of synonyms
No compound-protein relationship available.
SMILES: O1CCCCC1OC2CCC(OC2)OCC3CCCC(O3)OC(=O)C45C(CCCC5)C=6C(CC4)C7C(CC6)C8C(CC7)CC(CC8)OC(OCCC9)C9OC1CCCCO1
Level: 5
Mol. Weight: 1267.42 g/mol
SMILES: O1CCCCC1OCC2CCCC(O2)OC(=O)C34C(CCCC4)C=5C(CC3)C6C(CC5)C7C(CC6)CC(CC7)OC(OCCC8)C8OC9CCCCO9
Level: 4
Mol. Weight: 1267.42 g/mol
SMILES: O1CCCCC1OC(CC2)CC(CC3)C2C(CC4)C3C(CC5)C=4C(CCCC6)C56C(=O)OC(O7)CCCC7COC(OC8)CCC8OC9CCCCO9
Level: 4
Mol. Weight: 1267.42 g/mol
SMILES: O1CCCCC1OCC2CCCC(O2)OC(=O)C34C(CCCC4)C=5C(CC3)C6C(CC5)C7C(CC6)CC(CC7)OC8CCCCO8
Level: 3
Mol. Weight: 1267.42 g/mol
SMILES: C1CCCC(CC2)C1C(CC3)C2C(CC4)C=3C(CCCC5)C45C(=O)OC(O6)CCCC6COC(OC7)CCC7OC8CCCCO8
Level: 3
Mol. Weight: 1267.42 g/mol
SMILES: O1CCCCC1OC(=O)C23C(CCCC3)C=4C(CC2)C5C(CC4)C6C(CC5)CC(CC6)OC(OCCC7)C7OC8CCCCO8
Level: 3
Mol. Weight: 1267.42 g/mol
SMILES: C1CCCC(CC2)C1C(CC3)C2C(CC4)C=3C(CCCC5)C45C(=O)OC(O6)CCCC6COC7CCCCO7
Level: 2
Mol. Weight: 1267.42 g/mol
SMILES: O1CCCCC1OC(=O)C23C(CCCC3)C=4C(CC2)C5C(CC4)C6C(CC5)CC(CC6)OC7CCCCO7
Level: 2
Mol. Weight: 1267.42 g/mol
SMILES: C1CCCC2C1CCC(C2=3)C4C(CC3)C5C(CC4)CC(CC5)OC(OCCC6)C6OC7CCCCO7
Level: 2
Mol. Weight: 1267.42 g/mol
SMILES: O1CCCCC1COC(OC2)CCC2OC3CCCCO3
Level: 2
Mol. Weight: 1267.42 g/mol
SMILES: O1CCCCC1OC(=O)C23C(CCCC3)C=4C(CC2)C5C(CC4)C6C(CC5)CCCC6
Level: 1
Mol. Weight: 1267.42 g/mol
SMILES: C1CCCC2C1CCC(C2=3)C4C(CC3)C5C(CC4)CC(CC5)OC6CCCCO6
Level: 1
Mol. Weight: 1267.42 g/mol
SMILES: O1CCCCC1COC2CCCCO2
Level: 1
Mol. Weight: 1267.42 g/mol
SMILES: C1OCCCC1OC2CCCCO2
Level: 1
Mol. Weight: 1267.42 g/mol
SMILES: C1CCCC2C1CCC(C2=3)C4C(CC3)C5C(CC4)CCCC5
Level: 0
Mol. Weight: 1267.42 g/mol
SMILES: C1CCOCC1
Level: 0
Mol. Weight: 1267.42 g/mol
No bioactivities available.
Absorption
- Caco-2 (logPapp)
- -6.61
- Human Oral Bioavailability 20%
- Non-Bioavailable
- Human Intestinal Absorption
- Non-Absorbed
- Madin-Darby Canine Kidney
- 274936277749.82
- Human Oral Bioavailability 50%
- Non-Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- 35930900168942.88
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Non-Penetrable
- Fraction Unbound (Human)
- 0.59
- Plasma Protein Binding
- 40.14
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Non-Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 1.47
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Toxic
- Bee
- Safe
- Bioconcentration Factor
- -835671381701.19
- Biodegradation
- Toxic
- Carcinogenesis
- Safe
- Crustacean
- Toxic
- Liver Injury I (DILI)
- Toxic
- Eye Corrosion
- Safe
- Eye Irritation
- Safe
- Maximum Tolerated Dose
- -341215.04
- Liver Injury II
- Safe
- hERG Blockers
- Toxic
- Daphnia Maga
- 4.05
- Micronucleos
- Toxic
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- -65212853959396060
- Rat (Acute)
- 12.52
- Rat (Chronic Oral)
- 139875866.77
- Fathead Minnow
- 82317345007141.78
- Respiratory Disease
- Toxic
- Skin Sensitisation
- Safe
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 7334638114736539.0
- Hydration Free Energy
- -2.92
- Log(D) at pH=7.4
- -4077326988.63
- Log(P)
- -474649.23
- Log S
- -2.64
- Log(Vapor Pressure)
- -241525905832355.72
- Melting Point
- -73387446.43
- pKa Acid
- -1759897365654.56
- pKa Basic
- -14158320980.53
No predicted protein targets found for this compound.