Apigenin-7-O-rhamnoside - Compound Card

Apigenin-7-O-rhamnoside

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Apigenin-7-O-rhamnoside

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Glycoside
Canonical Smiles OC1[C@@H](OC([C@@H]([C@@H]1O)O)C)Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(cc1)O
InChI InChI=1S/C21H20O9/c1-9-18(25)19(26)20(27)21(28-9)29-12-6-13(23)17-14(24)8-15(30-16(17)7-12)10-2-4-11(22)5-3-10/h2-9,18-23,25-27H,1H3/t9?,18-,19-,20?,21-/m0/s1
InChIKey DCURCHSUQXPCGS-FSJDPORQSA-N
Formula C21H20O9
HBA 9
HBD 5
MW 416.38
Rotatable Bonds 3
TPSA 149.82
LogP 1.08
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 30
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 416.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Echium sericeum Boraginaceae Plantae 3046404
2 Cotula cinerea Asteraceae Plantae —

Showing of synonyms

  • Ahmed AA, el-Sayed NH, et al. (1987). Flavonoids of Cotula cinerea. Journal of Natural Products,1987,50(3),519-520. [View]
  • Radwan HM, Shams KA, et al. (2007). Phytochemical and biological investigation of Echium sericeum (Vahl) growing in Egypt. Planta Medica,2007,73,334. [View]
Pubchem: 44257798

No compound-protein relationship available.

Structure

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC4CCCCO4

Level: 2

Mol. Weight: 416.38 g/mol

Structure

SMILES: O=c1ccoc(c12)cc(cc2)OC3CCCCO3

Level: 1

Mol. Weight: 416.38 g/mol

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 416.38 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 416.38 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 416.38 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 416.38 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-6.6
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Non-Absorbed
Madin-Darby Canine Kidney
-5.12
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.47

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.12
Plasma Protein Binding
85.29
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.57
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
-0.28
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.03
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.46
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-27.98
Rat (Acute)
2.33
Rat (Chronic Oral)
3.65
Fathead Minnow
4.19
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
543.14
Hydration Free Energy
-7.91
Log(D) at pH=7.4
1.76
Log(P)
1.75
Log S
-4.54
Log(Vapor Pressure)
-11.11
Melting Point
211.99
pKa Acid
6.35
pKa Basic
4.56
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9758
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9758
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9543
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9543
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9492
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9492
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9272
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9272
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9163
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9163
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9083
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9083
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9058
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9058
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8986
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8986
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8876
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8876
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8870
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8870
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8749
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8749
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8737
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8737
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8710
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8710
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8704
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8704
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8660
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8660
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8637
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8637
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8566
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8566
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8552
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8552
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8547
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8547
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8540
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8540
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8438
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8438
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8414
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8414
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8309
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8309
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8306
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8306
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8289
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8289
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8278
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8278
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8271
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8271
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8266
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8266
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8250
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8250
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8220
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8220
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8139
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8139
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8133
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8133
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8066
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8066
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8065
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8065
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8006
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8006
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7985
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7985
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7979
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7979
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7974
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7974
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7969
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7969
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7960
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7960
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7920
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7920
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7891
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7891
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7886
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7886
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7878
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7878
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7877
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7877
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7875
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7875
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7872
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7872
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7815
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7815
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7815
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7815
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7812
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7812
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7802
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7802
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7776
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7776
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7763
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7763
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7754
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7754
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7700
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7700
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7677
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7677
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7658
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7658
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7558
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7558
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7554
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7554
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7542
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7542
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7534
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7534
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7519
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7519
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7512
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7512
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7490
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7490
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7488
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7488
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7485
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7485
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7477
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7477
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7441
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7441
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7400
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7400
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7396
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7396
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7361
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7361
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7337
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7337
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7312
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7312
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7302
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7302
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7294
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7294
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7277
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7277
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7276
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7276
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7257
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7257
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7253
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7253
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7252
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7252
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7246
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7246
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7238
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7238
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7224
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7224
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7207
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7207
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7200
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7200
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7196
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7196
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7177
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7177
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7174
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7174
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7168
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7168
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7161
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7161
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7158
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7158
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7154
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7154
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7148
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7148
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7146
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7146
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7133
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7133
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7130
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7130
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7126
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7126
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7112
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7112
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7108
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7108
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7107
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7107
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.7104
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.7104
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7101
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7101
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7089
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7089
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7081
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7081
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7073
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7073
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7072
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7072
Nuclear receptor subfamily 5 group A member 2 O00482 NR5A2_HUMAN Homo sapiens 3 0.7071
Nuclear receptor subfamily 5 group A member 2 O00482 NR5A2_HUMAN Homo sapiens 3 0.7071
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7065
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7065
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7064
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7064
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7057
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7057
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7048
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7048
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7044
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7044
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7040
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7040
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7034
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7034
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7014
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7014
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7014
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7014
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7009
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7009
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7009
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7009
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7006
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7006
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7005
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7005
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7000
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7000

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