5,7,4'-trihydroxy-3-methoxyflavone - Compound Card

5,7,4'-trihydroxy-3-methoxyflavone

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5,7,4'-trihydroxy-3-methoxyflavone

Structure
Zoomed Structure
  • Family: Asteraceae-Compositae, Sapindaceae, Leguminosae/Fabaceae, Capparaceae, Juglandaceae, Sisymbrieae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles COc1c(oc2c(c1=O)c(O)cc(c2)O)c1ccc(cc1)O
InChI InChI=1S/C16H12O6/c1-21-16-14(20)13-11(19)6-10(18)7-12(13)22-15(16)8-2-4-9(17)5-3-8/h2-7,17-19H,1H3
InChIKey VJJZJBUCDWKPLC-UHFFFAOYSA-N
Formula C16H12O6
HBA 6
HBD 3
MW 300.27
Rotatable Bonds 2
TPSA 100.13
LogP 2.59
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 300.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cleome species Capparaceae Plantae 25782
2 Curya pecan Juglandaceae Plantae 32201
3 Dodonaea viscosa Sapindaceae Plantae 151065
4 Centaurea furfuracea Asteraceae-Compositae Plantae 41503
5 Cheirolophus uliginosus Asteraceae-Compositae Plantae 65003
6 Jasonia candicans Asteraceae-Compositae Plantae 557631
7 Pallenis spinosa Asteraceae-Compositae Plantae 73981
8 Senecio roseiflorus Asteraceae-Compositae Plantae 1886451
9 Platycelyphium voënse Leguminosae/Fabaceae Plantae 149667
10 Dodonaea angustifolia Sapindaceae Plantae 379228
11 Sisymbrium irio Sisymbrieae Plantae 3730

Showing of synonyms

  • Omosa LK, Amugune B, et al. (2014). Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia. South African Journal of Botany,2014,91,58-62. [View] [PubMed]
  • Kerubo LO, Midiwo JO, et al. (2013). Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus. Natural Product Communications,2013,8(2),175-176. [View] [PubMed]
  • Marzouk M.M, Al-Nowaihi A.S.M, et al. (2010). Chemosystematic studies on certain species of the family Brassicaceae(Cruciferae) in Egypt. Biochemical Systematics and Ecology, 2010, 38(4), 680–685.. [View]
  • Sharaf M, Mansour RMA, et al. (1992). Exudate flavonoids from aerial parts of four Cleome species.. Biochemical Systematics and Ecology,1992,20(5),443-448. [View]
  • Akkal S, Benayache F, et al. (2003). Flavonoids from Centaurea furfuracea (Asteraceae). Biochemical Systematics and Ecology,2003,31,641-643. [View]
  • Ahmed AA, Spaller M, et al. (1992). Flavonoids of Pallenis spinosa (Asteraceae). Biochemical Systematics and Ecology,1992,20(8),785-786. [View]
  • Ishak MS, Ahmed AA, et al. (1980). Flavonol glycosides of Carya pecan. Phytochemistry,1980,19,2512-2513. [View]
  • Gumula I, Heydenreic M, et al. (2012). Four isoflavanones from the stem bark of Platycelphium voënse.. Phytochemistry Letters,2012,5(1),150–154. [View] [PubMed]
  • Mostafa AE, El-Hela AA, et al. (2014). New secondary metabolites from Dodonaea viscosa. Phytochemistry Letters,2014,8,10-15. [View]
  • Marco JA, Sanz-Cervera JF, et al. (1994). Sesquiterpene lactones, lignans and aromatic esters ftrom Cheirolophus species. Phytochemistry,1994,37(4),1101-1107. [View]
  • Ahmed AA, Mahmoud AA, et al. (1994). Two methylated flavonols from Jasonia candicans. Phytochemistry,1994,35(1),241-243. [View]
Pubchem: 5280862
Kegg Ligand: C05902
Chebi: 1579
Nmrshiftdb2: 60019426
Metabolights: MTBLC1579
Bindingdb: 50240899
CPRiL: 272717
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 222.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 146.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.99
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.930
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.44

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.070
Plasma Protein Binding
85.76
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.010
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.600
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.470
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.180
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.820
Rat (Acute)
2.340
Rat (Chronic Oral)
2.650
Fathead Minnow
4.620
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
470.640
Hydration Free Energy
-12.660
Log(D) at pH=7.4
2.830
Log(P)
3.2
Log S
-4.95
Log(Vapor Pressure)
-7.95
Melting Point
269.61
pKa Acid
7.22
pKa Basic
5.03
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9811
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9811
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9755
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9755
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9536
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9536
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9486
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9486
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9435
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9435
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9373
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9373
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9335
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9335
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9299
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9299
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9249
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9249
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9225
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9225
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9210
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9210
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9178
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9178
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9133
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9133
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9100
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9100
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.9097
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.9097
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9093
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9093
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9071
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9071
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9066
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9066
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9012
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9012
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9006
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9006
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8981
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8981
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8973
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8973
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8970
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8970
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8964
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8964
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8949
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8949
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8948
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8948
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8947
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8947
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8940
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8940
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8936
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8936
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8929
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8929
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8917
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8917
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8908
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8908
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8900
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8900
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8817
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8817
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8804
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8804
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8802
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8802
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8744
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8744
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8726
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8726
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8722
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8722
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8703
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8703
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8664
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8664
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8660
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8660
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8630
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8630
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8625
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8625
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8607
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8607
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8604
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8604
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8563
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8563
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8555
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8555
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8464
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8464
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8447
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8447
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8444
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8444
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8434
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8434
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.8422
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.8422
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8419
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8419
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8407
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8407
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8405
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8405
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8349
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8349
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8334
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8334
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8321
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8321
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8321
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8321
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8318
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8318
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8314
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8314
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8310
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8310
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8297
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8297
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8272
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8272
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8270
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8270
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8258
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8258
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8253
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8253
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8251
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8251
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8251
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8251
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8237
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8237
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8192
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8192
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8181
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8181
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8147
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8147
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8118
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8118
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8117
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8117
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8116
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8116
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8102
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8102
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8049
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8049
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8030
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8030
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8030
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8030
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8024
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8024
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8020
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8020
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8018
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8018
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7988
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7988
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7970
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7970
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7965
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7965
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7960
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7960
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7926
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7926
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7926
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7926
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7917
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7917
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7855
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7855
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7853
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7853
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7848
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7848
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7831
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7831
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7827
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7827
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7826
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7826
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7824
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7824
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7814
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7814
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7809
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7809
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7805
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7805
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7800
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7800
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7773
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7773
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7769
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7769
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7754
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7754
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7753
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7753
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7741
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7741
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7730
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7730
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7727
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7727
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7722
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7722
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7719
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7719
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7711
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7711
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7699
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7699
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7683
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7683
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7679
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7679
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7659
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7659
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7659
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7659
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7655
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7655
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7650
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7650
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7648
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7648
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7638
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7638
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7619
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7619
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7616
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7616
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7613
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7613
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7609
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7609
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7609
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7609
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7594
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7594
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7593
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7593
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7589
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7589
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7584
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7584
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7581
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7581
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7538
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7538
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7535
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7535
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7511
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7511
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7481
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7481
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7478
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7478
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7475
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7475
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7468
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7468
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7460
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7460
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7453
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7453
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7444
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7444
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7442
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7442
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7422
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7422
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7411
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7411
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7401
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7401
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7390
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7390
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7388
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7388
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7382
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7382
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7379
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7379
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7374
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7374
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7372
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7372
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7371
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7371
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7365
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7365
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7364
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7364
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7360
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7360
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7357
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7357
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7355
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7355
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7350
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7350
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7342
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7342
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7337
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7337
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7314
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7314
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7307
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7307
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7304
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7304
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7303
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7303
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7298
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7298
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7298
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7298
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7284
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7284
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7275
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7275
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7264
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7264
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7260
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7260
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7256
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7256
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7253
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7253
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7252
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7252
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7249
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7249
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7242
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7242
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7240
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7240
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7234
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7234
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7226
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7226
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7215
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7215
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7211
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7211
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7192
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7192
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7191
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7191
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7183
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7183
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7181
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7181
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7178
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7178
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7177
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7177
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7165
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7165
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7161
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7161
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7157
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7157
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7154
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7154
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7153
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7153
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7142
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7142
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7141
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7141
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7141
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7141
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7127
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7127
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7124
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7124
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7122
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7122
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7121
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7121
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7116
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7116
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7114
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7114
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7109
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7109
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7108
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7108
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7102
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7102
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7090
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7090
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7082
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7082
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7081
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7081
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7080
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7080
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7078
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7078
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7074
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7074
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7071
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7071
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7070
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7070
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7066
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7066
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7065
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7065
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7063
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7063
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7049
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7049
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7048
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7048
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7044
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7044
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7043
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7043
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7040
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7040
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7036
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7036
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7025
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7025
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7022
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7022
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7016
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7016
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7016
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7016
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7013
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7013
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7011
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7011
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7006
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7006
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7006
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7006
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7005
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7005
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7003
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7003

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