5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone - Compound Card

5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone

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5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone

Structure
Zoomed Structure
  • Family: Capparaceae, Asteraceae-Compositae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles COc1cc(cc(c1O)OC)c1cc(=O)c2c(o1)cc(c(c2O)OC)O
InChI InChI=1S/C18H16O8/c1-23-13-4-8(5-14(24-2)16(13)21)11-6-9(19)15-12(26-11)7-10(20)18(25-3)17(15)22/h4-7,20-22H,1-3H3
InChIKey BVRHGBHZAQNORL-UHFFFAOYSA-N
Formula C18H16O8
HBA 8
HBD 3
MW 360.32
Rotatable Bonds 4
TPSA 118.59
LogP 2.6
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 360.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cleome species Capparaceae Plantae 25782
2 Artemisia mesatlantica Asteraceae-Compositae Plantae 1287615

Showing of synonyms

  • Bouzid N, Fouraste I, et al. (1982). A methylated flavone from Artemisia mesatlantica. Phytochemistry,1982,21(3),803-804. [View]
  • Sharaf M, Mansour RMA, et al. (1992). Exudate flavonoids from aerial parts of four Cleome species.. Biochemical Systematics and Ecology,1992,20(5),443-448. [View]
Pubchem: 14034284
Nmrshiftdb2: 60027395

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 222.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 146.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.26
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.120
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.12

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.300
Plasma Protein Binding
86.25
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.890
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.530
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.350
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.880
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.660
Rat (Acute)
2.260
Rat (Chronic Oral)
2.950
Fathead Minnow
4.650
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
480.880
Hydration Free Energy
-10.480
Log(D) at pH=7.4
3.130
Log(P)
2.27
Log S
-6.11
Log(Vapor Pressure)
-7.7
Melting Point
222.37
pKa Acid
7.42
pKa Basic
3.5
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9767
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9767
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9658
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9658
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9629
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9629
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9584
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9584
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9407
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9407
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9112
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9112
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9053
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9053
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.9052
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.9052
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9009
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9009
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9006
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9006
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8974
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8974
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8932
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8932
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8863
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8863
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8860
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8860
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8782
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8782
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8777
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8777
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8750
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8750
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8723
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8723
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8690
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8690
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8683
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8683
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8607
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8607
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8599
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8599
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8591
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8591
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8586
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8586
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8539
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8539
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8537
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8537
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8535
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8535
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8521
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8521
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8495
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8495
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8490
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8490
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8484
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8484
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8480
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8480
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8478
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8478
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8474
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8474
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8472
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8472
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8461
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8461
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8452
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8452
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8439
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8439
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8433
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8433
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8410
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8410
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8392
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8392
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8377
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8377
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8370
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8370
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8369
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8369
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8361
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8361
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8353
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8353
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8347
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8347
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8302
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8302
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8290
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8290
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8273
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8273
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8260
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8260
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8258
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8258
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 4 0.8227
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 4 0.8227
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8205
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8205
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8184
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8184
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8181
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8181
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8175
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8175
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8162
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8162
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8155
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8155
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8144
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8144
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8139
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8139
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8121
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8121
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8118
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8118
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8117
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8117
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8110
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8110
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8080
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8080
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8073
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8073
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8070
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8070
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8066
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8066
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8056
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8056
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8048
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8048
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8019
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8019
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7990
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7990
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7963
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7963
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7955
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7955
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7948
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7948
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7947
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7947
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7945
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7945
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7907
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7907
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7900
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7900
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7865
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7865
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7856
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7856
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7848
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7848
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7845
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7845
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7828
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7828
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7812
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7812
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7797
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7797
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7781
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7781
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7774
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7774
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7765
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7765
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7739
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7739
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7731
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7731
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7713
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7713
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7699
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7699
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7676
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7676
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7669
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7669
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7664
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7664
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7656
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7656
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7647
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7647
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7625
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7625
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7615
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7615
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7612
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7612
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7608
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7608
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7603
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7603
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7602
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7602
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7582
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7582
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7568
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7568
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7568
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7568
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7566
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7566
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7547
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7547
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7531
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7531
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7521
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7521
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7518
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7518
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7511
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7511
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.7494
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.7494
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7484
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7484
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7473
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7473
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7470
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7470
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7444
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7444
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7411
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7411
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7402
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7402
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7401
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7401
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7398
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7398
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7387
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7387
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7375
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7375
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7374
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7374
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7370
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7370
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7370
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7370
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7359
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7359
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7350
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7350
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7349
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7349
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7330
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7330
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7327
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7327
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7323
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7323
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7313
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7313
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7305
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7305
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7303
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7303
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7301
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7301
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7290
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7290
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7277
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7277
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7267
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7267
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7263
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7263
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 3 0.7243
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 3 0.7243
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7234
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7234
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7231
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7231
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7230
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7230
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7227
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7227
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7215
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7215
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7206
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7206
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7203
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7193
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7193
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7192
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7192
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7185
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7185
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7183
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7183
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7170
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7170
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7158
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7158
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7147
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7147
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7132
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7132
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7111
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7111
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7110
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7110
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7107
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7107
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7103
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7103
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7098
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7098
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7094
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7094
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7091
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7091
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7091
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7091
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7090
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7090
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7078
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7078
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7063
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7063
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7057
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7057
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7032
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7032
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7026
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7026
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7014
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7014
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7013
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7013
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7012
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7012
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7011
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7011

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