5-hydroxy-3,6,7,3',4',5'-hexamethoxyflavone - Compound Card

5-hydroxy-3,6,7,3',4',5'-hexamethoxyflavone

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5-hydroxy-3,6,7,3',4',5'-hexamethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Rhamnaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles COc1c(OC)cc(cc1OC)c1oc2cc(OC)c(c(c2c(=O)c1OC)O)OC
InChI InChI=1S/C21H22O9/c1-24-12-7-10(8-13(25-2)19(12)27-4)18-21(29-6)17(23)15-11(30-18)9-14(26-3)20(28-5)16(15)22/h7-9,22H,1-6H3
InChIKey XZKJITYVVLNMNW-UHFFFAOYSA-N
Formula C21H22O9
HBA 9
HBD 1
MW 418.4
Rotatable Bonds 7
TPSA 105.82
LogP 3.22
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 30
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 418.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cleome species Capparaceae Plantae 25782
2 Cleome droserifolia Capparaceae Plantae 511510
3 Rhamnus disperma Rhamnaceae Plantae 1813078

Showing of synonyms

  • Fathy HM, Aboushoer MI, et al. (2008). Dolabellane diterpenes from Cleome droserifolia. Natural Product Communications,2008,3(9),1479-1482. [View]
  • Sharaf M, Mansour RMA, et al. (1992). Exudate flavonoids from aerial parts of four Cleome species.. Biochemical Systematics and Ecology,1992,20(5),443-448. [View]
  • Mohammed H.A, Abd El-Wahab M.F, et al. (2021). Isolation, Characterization, Complete Structural Assignment,and Anticancer Activities of the Methoxylated Flavonoids from Rhamnus disperma Roots. Molecules, 2021, 26(19), 5827. [View] [PubMed]
Pubchem: 14037441
Nmrshiftdb2: 70016565

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 418.4 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 418.4 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 418.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.7
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.840
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.22

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.300
Plasma Protein Binding
68.15
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.260
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.050
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.190
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.640
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-23.520
Rat (Acute)
2.600
Rat (Chronic Oral)
2.370
Fathead Minnow
5.400
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
476.540
Hydration Free Energy
-6.320
Log(D) at pH=7.4
3.000
Log(P)
2.82
Log S
-3.44
Log(Vapor Pressure)
-7.69
Melting Point
167.97
pKa Acid
7.55
pKa Basic
0.12
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9464
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9464
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9399
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9399
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9365
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9365
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9313
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9313
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9107
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9107
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9071
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9071
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9016
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9016
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8993
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8993
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8989
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8989
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8980
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8980
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8978
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8978
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8974
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8974
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8962
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8962
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8786
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8786
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8771
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8771
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8738
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8738
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8722
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8722
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8720
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8720
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8718
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8718
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8668
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8668
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8642
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8642
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8578
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8578
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8506
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8506
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8486
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8486
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8432
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8432
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8402
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8402
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8365
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8365
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8296
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8296
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8275
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8275
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8275
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8275
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8274
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8274
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8262
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8262
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8232
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8232
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8188
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8188
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8167
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8167
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8121
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8121
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8118
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8118
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8096
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8096
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8086
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8086
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8061
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8061
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8007
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8007
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7994
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7994
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7979
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7979
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7979
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7979
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7971
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7971
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7917
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7917
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7884
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7884
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7881
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7881
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7880
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7880
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7871
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7871
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7862
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7862
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7859
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7859
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7849
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7849
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7847
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7847
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7822
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7822
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7813
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7813
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7800
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7800
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7773
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7773
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7766
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7766
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7747
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7747
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7716
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7716
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7680
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7680
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7674
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7674
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7668
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7668
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7666
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7666
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7652
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7652
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7586
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7586
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7585
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7585
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7578
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7578
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7574
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7574
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7562
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7562
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7530
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7530
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7527
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7527
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7514
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7514
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7506
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7506
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7493
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7493
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7480
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7480
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7444
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7444
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7433
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7433
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7428
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7428
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7401
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7401
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7396
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7396
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7376
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7376
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7368
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7368
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7360
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7360
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7353
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7353
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7351
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7351
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7348
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7348
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7340
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7340
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7330
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7330
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7323
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7323
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7302
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7302
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7293
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7293
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7288
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7288
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7288
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7288
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7288
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7288
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7285
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7285
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7283
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7283
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7270
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7270
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7268
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7268
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7243
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7243
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7243
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7243
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7242
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7242
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7227
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7227
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7214
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7214
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7209
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7209
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7193
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7193
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7182
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7182
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7163
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7163
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7129
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7129
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7127
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7127
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7105
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7105
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7098
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7098
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7096
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7096
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7086
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7086
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7083
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7083
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7077
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7077
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7073
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7073
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7073
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7073
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7072
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7072
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7066
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7066
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7065
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7065
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7035
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7035
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7032
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7032
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7031
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7031
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7025
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7025
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7020
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7020
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7012
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7012
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7011
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7011
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7003
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7003

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