4'-hydroxy-3,3',4,5,5'-pentamethoxy-7,9':7',9-diepoxylignane - Compound Card

4'-hydroxy-3,3',4,5,5'-pentamethoxy-7,9':7',9-diepoxylignane

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4'-hydroxy-3,3',4,5,5'-pentamethoxy-7,9':7',9-diepoxylignane

Structure
Zoomed Structure
  • Family: Capparaceae
  • Kingdom: Plantae
  • Class: Lignan
    • Subclass: Diepoxylignan
Canonical Smiles COc1cc(cc(c1OC)OC)[C@H]1OC[C@H]2[C@@H]1CO[C@@H]2c1cc(OC)c(c(c1)OC)O
InChI InChI=1S/C23H28O8/c1-25-16-6-12(7-17(26-2)20(16)24)21-14-10-31-22(15(14)11-30-21)13-8-18(27-3)23(29-5)19(9-13)28-4/h6-9,14-15,21-22,24H,10-11H2,1-5H3/t14-,15-,21+,22+/m0/s1
InChIKey AJMQKDTUOKAQNT-ZYNNUQKQSA-N
Formula C23H28O8
HBA 8
HBD 1
MW 432.47
Rotatable Bonds 7
TPSA 84.84
LogP 3.51
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 31
Formal Charge 0
Fraction CSP3 0.48
Exact Mass 432.18
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Boscia senegalensis Capparaceae Plantae 1198336

Showing of synonyms

  • Morgan AMA, Lim CH, et al. (2015). Lignans, cyclolignans and neolignans from the leaves of Boscia senegalensis (Pers.) Lam. ex Poir.. Biochemical Systematics and Ecology,2015,59,226-228. [View]
Pubchem: 44555396

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(OC2)C(C23)COC3c4ccccc4

Level: 2

Mol. Weight: 266.34 g/mol

Structure

SMILES: C1OCC(C12)COC2c3ccccc3

Level: 1

Mol. Weight: 190.24 g/mol

Structure

SMILES: C1OCC(C12)COC2

Level: 0

Mol. Weight: 114.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.84
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.890
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.02

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.990
Plasma Protein Binding
76.83
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.530
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.820
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.600
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
6.490
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-85.340
Rat (Acute)
2.380
Rat (Chronic Oral)
2.210
Fathead Minnow
4.580
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
454.110
Hydration Free Energy
-3.200
Log(D) at pH=7.4
2.930
Log(P)
2.14
Log S
-3.67
Log(Vapor Pressure)
-8.25
Melting Point
151.74
pKa Acid
8.68
pKa Basic
2.27
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9694
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9694
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9495
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9495
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9486
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9486
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9472
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9472
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9285
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9285
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9276
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9276
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9208
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9208
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.9188
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.9188
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.9082
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.9082
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8988
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8988
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8968
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8968
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8903
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8903
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.8795
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.8795
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8784
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8784
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8744
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8744
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8687
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8687
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8593
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8593
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8561
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8561
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8559
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8559
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8497
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8497
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8474
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8474
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8424
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8424
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 5 0.8422
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 5 0.8422
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8401
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8401
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 4 0.8385
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 4 0.8385
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8367
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8367
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8312
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8312
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8272
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8272
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8265
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8265
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8244
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8244
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8181
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8181
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8178
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8178
Uracil-DNA glycosylase P9WFQ9 UNG_MYCTU Mycobacterium tuberculosis 4 0.8064
Uracil-DNA glycosylase P9WFQ9 UNG_MYCTU Mycobacterium tuberculosis 4 0.8064
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.8033
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.8033
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8030
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8030
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8016
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8016
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 4 0.7997
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 4 0.7997
Thymidylate kinase Q9KQI2 KTHY_VIBCH Vibrio cholerae serotype O1 4 0.7978
Thymidylate kinase Q9KQI2 KTHY_VIBCH Vibrio cholerae serotype O1 4 0.7978
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 4 0.7957
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 4 0.7957
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7956
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7956
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7928
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7928
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7907
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7907
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7906
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7906
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7898
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7898
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7849
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7849
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.7783
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.7783
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 4 0.7746
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 4 0.7746
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7734
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7734
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7730
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7730
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7724
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7724
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7721
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7721
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7664
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7664
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7637
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7637
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.7556
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.7556
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7552
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7552
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7552
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7552
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7540
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7540
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7498
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7498
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7492
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7492
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7490
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7490
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7486
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7486
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7472
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7472
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7460
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7460
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7457
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7457
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7443
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7443
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7425
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7425
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7424
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7424
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7409
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7409
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7399
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7399
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7394
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7394
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7386
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7386
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7369
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7369
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7364
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7364
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7362
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7362
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7353
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7353
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7343
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7343
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7342
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7342
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7332
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7332
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7327
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7327
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7318
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7318
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7310
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7310
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7303
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7303
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7299
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7299
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7298
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7298
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7292
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7292
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7280
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7280
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7280
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7280
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7264
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7264
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7256
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7256
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7244
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7244
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7238
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7238
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7217
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7217
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7216
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7216
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7214
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7214
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7212
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7212
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7202
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7202
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7197
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7197
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7193
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7193
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7190
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7190
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7183
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7183
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7183
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7183
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7176
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7176
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7172
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7172
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7165
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7165
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7145
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7145
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7141
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7141
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7132
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7132
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7130
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7130
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7128
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7128
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7127
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7127
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7124
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7124
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7118
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7118
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7117
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7117
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7108
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7108
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7099
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7099
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7087
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7087
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7085
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7085
Interleukin-1 receptor-associated kinase 4 Q9NWZ3 IRAK4_HUMAN Homo sapiens 3 0.7082
Interleukin-1 receptor-associated kinase 4 Q9NWZ3 IRAK4_HUMAN Homo sapiens 3 0.7082
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7079
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7079
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7074
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7074
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7073
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7073
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7039
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7039
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7036
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7036
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7029
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7029
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7017
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7017
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7015
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7015
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7009
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7009

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