Alangilignoside D - Compound Card

Alangilignoside D

Select a section from the left sidebar

Alangilignoside D

Structure
Zoomed Structure
  • Family: Plantae - Capparaceae
  • Kingdom: Plantae
  • Class: Lignan
    • Subclass: Epoxylignan
Canonical Smiles OC[C@H]1O[C@@H](OC[C@H]2[C@H](CO[C@@H]2c2cc(OC)c(c(c2)OC)O)c2ccc(c(c2)OC)O)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C26H34O12/c1-33-17-6-12(4-5-16(17)28)14-10-36-25(13-7-18(34-2)21(29)19(8-13)35-3)15(14)11-37-26-24(32)23(31)22(30)20(9-27)38-26/h4-8,14-15,20,22-32H,9-11H2,1-3H3/t14-,15+,20-,22-,23+,24-,25-,26-/m1/s1
InChIKey DAUYODIWUKXRGZ-BILHOKJUSA-N
Formula C26H34O12
HBA 12
HBD 6
MW 538.55
Rotatable Bonds 9
TPSA 176.76
LogP 0.41
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 38
Formal Charge 0
Fraction CSP3 0.54
Exact Mass 538.21
Number of Lipinski Rule Violations 3
# Species Family Kingdom NCBI Taxonomy ID
1 Boscia senegalensis Capparaceae Plantae 1198336

Showing of synonyms

  • Morgan AMA, Lim CH, et al. (2015). Lignans, cyclolignans and neolignans from the leaves of Boscia senegalensis (Pers.) Lam. ex Poir.. Biochemical Systematics and Ecology,2015,59,226-228. [View]
Pubchem: 101705431
Nmrshiftdb2: 60049671

No compound-protein relationship available.

Structure

SMILES: O1CCCCC1OCC2C(c3ccccc3)COC2c4ccccc4

Level: 3

Mol. Weight: 538.55 g/mol

Structure

SMILES: O1CCCCC1OCC2C(OCC2)c3ccccc3

Level: 2

Mol. Weight: 538.55 g/mol

Structure

SMILES: O1CCCCC1OCC2C(COC2)c3ccccc3

Level: 2

Mol. Weight: 538.55 g/mol

Structure

SMILES: c1ccccc1C2CC(OC2)c3ccccc3

Level: 2

Mol. Weight: 538.55 g/mol

Structure

SMILES: C1OCCC1COC2CCCCO2

Level: 1

Mol. Weight: 538.55 g/mol

Structure

SMILES: O1CCCC1c2ccccc2

Level: 1

Mol. Weight: 538.55 g/mol

Structure

SMILES: C1OCCC1c2ccccc2

Level: 1

Mol. Weight: 538.55 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 538.55 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 538.55 g/mol

Structure

SMILES: C1CCOC1

Level: 0

Mol. Weight: 538.55 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-6.57
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Non-Absorbed
Madin-Darby Canine Kidney
-5.140
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
0.15

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.830
Plasma Protein Binding
78.04
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.000
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
-1.920
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.540
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
5.760
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-1833.200
Rat (Acute)
2.340
Rat (Chronic Oral)
3.880
Fathead Minnow
6.000
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
516.460
Hydration Free Energy
-2.980
Log(D) at pH=7.4
0.630
Log(P)
-1.16
Log S
-4.11
Log(Vapor Pressure)
-10.76
Melting Point
181.02
pKa Acid
6.34
pKa Basic
3.39
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9436
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9436
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9258
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9258
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9111
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9111
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.9074
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.9074
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.9054
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.9054
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9017
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9017
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8979
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8979
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8829
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8829
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8793
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8793
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8576
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8576
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8547
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8547
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8438
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8438
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8433
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8433
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8413
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8413
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8365
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8365
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8358
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8358
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.8280
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.8280
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8247
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8247
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8179
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8179
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8152
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8152
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8139
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8139
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8130
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8130
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8064
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8064
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8036
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8036
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7962
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7962
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7874
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7874
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7870
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7870
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7839
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7839
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7825
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7825
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 3 0.7820
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 3 0.7820
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7780
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7780
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7763
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7763
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 4 0.7720
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 4 0.7720
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7660
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7660
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7636
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7636
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7612
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7612
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 4 0.7608
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 4 0.7608
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7600
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7600
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7585
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7585
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7577
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7577
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7576
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7576
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7526
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7526
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.7514
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.7514
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7503
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7503
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7498
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7498
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.7427
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.7427
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.7398
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.7398
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7393
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7393
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7367
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7367
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7349
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7349
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7345
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7345
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 4 0.7339
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 4 0.7339
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7323
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7323
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7301
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7301
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7295
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7295
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7286
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7286
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7276
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7276
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7258
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7258
Putative b-glycan phosphorylase Q21MB1 Q21MB1_SACD2 Saccharophagus degradans 4 0.7252
Putative b-glycan phosphorylase Q21MB1 Q21MB1_SACD2 Saccharophagus degradans 4 0.7252
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7250
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7250
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7230
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7230
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7227
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7227
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7219
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7219
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7198
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7198
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7194
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7194
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7188
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7188
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7179
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7179
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7153
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7153
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7152
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7152
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7140
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7140
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7130
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7130
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7117
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7117
Small heat shock protein StHsp14.0 Q970D9 Q970D9_SULTO Sulfurisphaera tokodaii 3 0.7096
Small heat shock protein StHsp14.0 Q970D9 Q970D9_SULTO Sulfurisphaera tokodaii 3 0.7096
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7093
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7093
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7089
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7089
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7082
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7082
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7079
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7079
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7073
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7073
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7034
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7034
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7029
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7029
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7025
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7025
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7007
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7007

Download SDF