(-)-4'-methylepigallocatechin - Compound Card

(-)-4'-methylepigallocatechin

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(-)-4'-methylepigallocatechin

Structure
Zoomed Structure
  • Family: Plantae - Celastraceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1c(O)cc(cc1O)[C@H]1Oc2cc(O)cc(c2C[C@H]1O)OC
InChI InChI=1S/C17H18O7/c1-22-14-5-9(18)6-15-10(14)7-13(21)16(24-15)8-3-11(19)17(23-2)12(20)4-8/h3-6,13,16,18-21H,7H2,1-2H3/t13-,16-/m1/s1
InChIKey BOQRGNNIHUELJI-CZUORRHYSA-N
Formula C17H18O7
HBA 7
HBD 4
MW 334.32
Rotatable Bonds 3
TPSA 108.61
LogP 1.86
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 334.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Maytenus senegalensis Celastraceae Plantae 256095

Showing of synonyms

  • Hussein G, Miyashiro H, et al. (1999). Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease. Phytotherapy Research,1999,13(1),31-36. [View] [PubMed]
Pubchem: 476780
Nmrshiftdb2: 70023440

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2)c3ccccc3

Level: 1

Mol. Weight: 334.32 g/mol

Structure

SMILES: C1CCOc(c12)cccc2

Level: 0

Mol. Weight: 334.32 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 334.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.88
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.220
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.64

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.900
Plasma Protein Binding
73.64
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
14.100
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.940
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.710
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
6.090
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.870
Rat (Acute)
2.150
Rat (Chronic Oral)
3.010
Fathead Minnow
4.180
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
445.530
Hydration Free Energy
-10.290
Log(D) at pH=7.4
2.230
Log(P)
1.16
Log S
-3.73
Log(Vapor Pressure)
-7.38
Melting Point
176.44
pKa Acid
8.22
pKa Basic
3.74
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9559
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9559
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9291
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9291
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9112
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9112
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9027
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9027
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8998
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8998
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8963
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8963
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8960
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8960
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8929
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8929
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8897
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8897
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8852
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8852
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8808
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8808
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8752
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8752
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 5 0.8740
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 5 0.8740
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8707
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8707
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8683
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8683
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8675
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8675
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8665
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8665
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8650
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8650
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8609
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8609
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.8593
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.8593
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8583
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8583
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8570
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8570
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8564
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8564
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8545
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8545
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8521
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8521
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8452
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8452
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8449
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8449
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8447
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8447
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8415
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8415
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8408
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8408
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8406
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8406
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8372
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8372
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8371
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8371
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8324
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8324
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 4 0.8310
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 4 0.8310
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8234
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8234
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8227
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8227
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8221
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8221
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8205
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8205
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8201
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8201
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8196
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8196
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 4 0.8155
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 4 0.8155
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8139
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8139
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8116
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8116
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8111
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8111
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8099
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8099
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8091
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8091
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8050
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8050
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8027
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8027
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8022
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8022
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7999
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7999
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7959
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7959
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7946
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7946
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7922
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7922
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7918
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7918
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7876
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7876
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7857
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7857
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7853
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7853
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7852
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7852
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7849
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7849
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 6 0.7829
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 6 0.7829
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7806
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7806
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7793
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7793
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7773
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7773
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7773
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7773
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7771
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7771
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7760
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7760
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7758
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7758
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7754
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7754
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7754
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7754
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7735
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7735
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7712
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7712
Cyclic nucleotide-binding protein B8FW11 B8FW11_DESHD Desulfitobacterium hafniense 3 0.7706
Cyclic nucleotide-binding protein B8FW11 B8FW11_DESHD Desulfitobacterium hafniense 3 0.7706
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7699
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7699
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.7650
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.7650
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7626
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7626
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7623
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7623
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7622
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7622
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7603
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7603
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7589
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7589
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7589
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7589
Laminarinase Q9WXN1 Q9WXN1_THEMA Thermotoga maritima 3 0.7587
Laminarinase Q9WXN1 Q9WXN1_THEMA Thermotoga maritima 3 0.7587
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7560
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7560
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7545
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7545
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7518
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7518
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7508
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7508
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7483
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7483
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7480
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7480
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7465
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7465
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7463
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7463
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7451
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7451
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7450
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7450
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 4 0.7441
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 4 0.7441
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7426
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7426
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7422
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7422
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7422
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7422
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7418
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7418
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7416
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7416
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7409
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7409
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.7403
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.7403
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7398
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7398
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7392
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7392
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7392
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7392
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7390
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7390
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7355
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7355
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7331
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7331
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7320
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7320
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7311
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7311
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7309
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7309
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7306
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7306
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7303
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7303
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7277
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7277
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7269
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7269
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7268
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7268
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7268
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7268
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7263
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7263
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7257
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7257
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7246
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7246
Bifunctional adenosylcobalamin biosynthesis protein CobU Q05599 COBU_SALTY Salmonella typhimurium 4 0.7244
Bifunctional adenosylcobalamin biosynthesis protein CobU Q05599 COBU_SALTY Salmonella typhimurium 4 0.7244
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7238
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7238
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7237
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7237
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7235
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7235
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7233
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7233
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7228
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7228
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7228
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7228
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7219
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7219
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7203
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7203
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7179
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7179
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7177
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7177
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7177
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7177
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7168
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7168
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7167
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7167
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7164
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7164
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7163
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7163
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7132
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7132
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7132
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7132
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7126
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7126
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7125
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7125
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7124
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7124
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7120
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7120
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7118
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7118
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7113
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7113
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7100
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7100
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 5 0.7097
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 5 0.7097
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7073
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7073
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7069
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7069
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7064
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7064
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7062
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7062
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7059
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7059
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7053
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7053
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7036
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7036
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7035
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7035
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7032
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7032
Purine nucleoside phosphorylase B9JYS2 B9JYS2_AGRVS Agrobacterium vitis 4 0.7030
Purine nucleoside phosphorylase B9JYS2 B9JYS2_AGRVS Agrobacterium vitis 4 0.7030
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.7029
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7029
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.7029
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7029
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7026
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7026
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7019
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7019
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7010
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7010

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