Tetranin B - Compound Card

Tetranin B

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Tetranin B

Structure
Zoomed Structure
  • Family: Plantae - Chenopodiaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Bibenzyl Isoflavonoid
Canonical Smiles COc1ccc(c(c1)c1coc2c(c1=O)c(O)c1c(c2)OCO1)O
InChI InChI=1S/C17H12O7/c1-21-8-2-3-11(18)9(4-8)10-6-22-12-5-13-17(24-7-23-13)16(20)14(12)15(10)19/h2-6,18,20H,7H2,1H3
InChIKey LBUWDVBKYGJEMF-UHFFFAOYSA-N
Formula C17H12O7
HBA 7
HBD 2
MW 328.28
Rotatable Bonds 2
TPSA 98.36
LogP 2.61
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 328.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Salsola tetrandra Chenopodiaceae Plantae 264975

Showing of synonyms

  • Beyaoui A, Chaari A, et al. (2012). New antioxidant bibenzyl derivative and isoflavonoid from the Tunisian Salsola tetrandra Folsk. Natural Product Research,2012,26(3),235-242. [View] [PubMed]
Pubchem: 123462274
Nmrshiftdb2: 70114776

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)cc3c(c2)c(=O)c(co3)-c4ccccc4

Level: 1

Mol. Weight: 328.28 g/mol

Structure

SMILES: O1COc(c12)cc3c(c2)c(=O)cco3

Level: 0

Mol. Weight: 328.28 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 328.28 g/mol

Antioxidant

Absorption

Caco-2 (logPapp)
-4.66
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.790
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.75

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.370
Plasma Protein Binding
82.93
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.590
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.460
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.490
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.540
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.490
Rat (Acute)
2.330
Rat (Chronic Oral)
2.270
Fathead Minnow
4.860
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
467.590
Hydration Free Energy
-10.570
Log(D) at pH=7.4
3.030
Log(P)
3.49
Log S
-5.5
Log(Vapor Pressure)
-8.52
Melting Point
204.17
pKa Acid
7.27
pKa Basic
2.14
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9718
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9718
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9474
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9474
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9452
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9452
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9416
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9416
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9363
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9363
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9314
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9314
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9256
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9256
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9212
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9212
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9162
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9162
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9145
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9145
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9039
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9039
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9028
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9028
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9014
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9014
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8996
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8996
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8977
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8977
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8962
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8962
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8894
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8894
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8821
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8821
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8808
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8808
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8802
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8802
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8800
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8800
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8799
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8799
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8787
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8787
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8763
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8763
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8756
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8756
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8746
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8746
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8740
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8740
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8720
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8720
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8708
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8708
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8679
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8679
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8627
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8627
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8607
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8607
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8605
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8605
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8590
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8590
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8574
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8574
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8562
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8562
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8472
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8472
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8387
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8387
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8376
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8376
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.8298
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.8298
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8297
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8297
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8293
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8293
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8287
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8287
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8271
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8271
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8267
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8267
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8252
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8252
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.8231
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.8231
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8221
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8221
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8136
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8136
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8101
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8101
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8098
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8098
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8092
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8092
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8090
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8090
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8079
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8079
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8072
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8072
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8033
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8033
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8032
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8032
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8018
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8018
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8004
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8004
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7997
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7997
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7969
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7969
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7964
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7964
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7962
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7962
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7950
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7950
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 5 0.7935
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 5 0.7935
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7914
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7914
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7912
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7912
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7900
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7900
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7881
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7881
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7875
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7875
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7870
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7870
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7828
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7828
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7824
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7824
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7792
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7792
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7792
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7792
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7784
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7784
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7771
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7771
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7765
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7765
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7754
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7754
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7752
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7752
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7742
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7742
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7740
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7740
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7725
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7725
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7711
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7711
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7711
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7711
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7682
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7682
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7678
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7678
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7677
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7677
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7660
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7660
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7625
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7625
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7620
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7620
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7619
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7619
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7597
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7597
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7595
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7595
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7567
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7567
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7539
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7539
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7535
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7535
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7502
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7502
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7490
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7490
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7485
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7485
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7482
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7482
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7480
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7480
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7479
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7479
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7478
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7478
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7474
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7474
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7453
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7453
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7449
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7449
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7436
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7436
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7415
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7415
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7411
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7411
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7407
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7407
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7405
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7405
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7402
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7402
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7396
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7396
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7391
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7391
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7390
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7390
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7383
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7383
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7382
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7382
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7366
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7366
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7366
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7366
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7359
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7359
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7342
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7342
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7335
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7335
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7332
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7332
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7331
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7331
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7328
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7328
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7327
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7327
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7325
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7325
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7324
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7324
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7318
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7318
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7317
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7317
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7315
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7315
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7310
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7310
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7304
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7304
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7283
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7283
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7274
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7274
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7268
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7268
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7264
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7264
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7253
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7253
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7249
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7249
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7217
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7217
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7212
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7212
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7210
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7210
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7195
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7195
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7180
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7180
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7179
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7179
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7178
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7178
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7170
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7170
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7168
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7168
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7167
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7167
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7166
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7166
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7160
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7160
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7158
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7158
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7151
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7151
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7147
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7147
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7146
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7146
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7145
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7145
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7139
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7139
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7132
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7132
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7129
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7129
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7128
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7128
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7124
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7124
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7122
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7122
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7115
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7115
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7114
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7114
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7111
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7111
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7083
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7083
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7079
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7079
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.7077
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.7077
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7076
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7076
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7067
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7067
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7063
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7063
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7059
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7059
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7053
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7053
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7047
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7047
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7045
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7045
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7025
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7025
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7020
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7020
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7018
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7018
Primosomal protein N' A6TGC5 A6TGC5_KLEP7 Klebsiella pneumoniae subsp. pneumoniae 4 0.7012
Primosomal protein N' A6TGC5 A6TGC5_KLEP7 Klebsiella pneumoniae subsp. pneumoniae 4 0.7012
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7006
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7006

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