3-O-beta-D-xylopyranosyl-(1→2)-O-beta-D-glucuronopyranosyl-29-hydroxyoleanolic acid 28-O-beta-D-glucopyranoside
- Family: Plantae - Chenopodiaceae
- Kingdom: Plantae
-
Class: Terpenoid
- Subclass: Triterpene Glycoside
Canonical Smiles | OC[C@@H]1O[C@H](OC(=O)[C@]23CC[C@@]4(C(=CCC5[C@@]4(C)CCC4[C@]5(C)CC[C@@H](C4(C)C)O[C@H]4O[C@@H](C(=O)O)[C@@H]([C@H]([C@@H]4O)OC4OC[C@@H]([C@H]([C@@H]4O)O)O)O)C3C[C@](CC2)(C)CO)C)[C@H]([C@@H]([C@H]1O)O)O |
---|---|
InChI | InChI=1S/C47H74O19/c1-42(2)25-9-12-46(6)26(44(25,4)11-10-27(42)63-40-34(57)35(33(56)36(65-40)37(58)59)64-38-31(54)28(51)23(50)19-61-38)8-7-21-22-17-43(3,20-49)13-15-47(22,16-14-45(21,46)5)41(60)66-39-32(55)30(53)29(52)24(18-48)62-39/h7,22-36,38-40,48-57H,8-20H2,1-6H3,(H,58,59)/t22?,23-,24-,25?,26?,27-,28+,29-,30+,31-,32-,33+,34-,35+,36+,38?,39+,40-,43+,44-,45+,46+,47-/m0/s1 |
InChIKey | QEKUYFPBICSGHK-JBVQKBDOSA-N |
Formula | C47H74O19 |
HBA | 18 |
HBD | 11 |
MW | 943.09 |
Rotatable Bonds | 9 |
TPSA | 312.05 |
LogP | -0.16 |
Number Rings | 8 |
Number Aromatic Rings | 0 |
Heavy Atom Count | 66 |
Formal Charge | 0 |
Fraction CSP3 | 0.91 |
Exact Mass | 942.48 |
Number of Lipinski Rule Violations | 3 |
# | Species | Family | Kingdom | NCBI Taxonomy ID |
---|---|---|---|---|
1 | Salsola imbricata | Chenopodiaceae | Plantae | 1194693 |
Showing of synonyms
- Hamed AI, Masullo M, et al. (2011). Triterpene saponins from Salsola imbricata. Phytochemistry Letters,2011,4(3),353-356. [View]
No compound-protein relationship available.
SMILES: O1CCCCC1OC(=O)C23C(CCCC3)C=4C(CC2)C5C(CC4)C6C(CC5)CC(CC6)OC(OCC7)CC7OC8CCCCO8
Level: 3
Mol. Weight: 943.09 g/mol
SMILES: O1CCCCC1OC(=O)C23C(CCCC3)C=4C(CC2)C5C(CC4)C6C(CC5)CC(CC6)OC7CCCCO7
Level: 2
Mol. Weight: 943.09 g/mol
SMILES: C1CCCC2C1CCC(C2=3)C4C(CC3)C5C(CC4)CC(CC5)OC(OCC6)CC6OC7CCCCO7
Level: 2
Mol. Weight: 943.09 g/mol
SMILES: O1CCCCC1OC(=O)C23C(CCCC3)C=4C(CC2)C5C(CC4)C6C(CC5)CCCC6
Level: 1
Mol. Weight: 943.09 g/mol
SMILES: C1CCCC2C1CCC(C2=3)C4C(CC3)C5C(CC4)CC(CC5)OC6CCCCO6
Level: 1
Mol. Weight: 943.09 g/mol
SMILES: C1COCCC1OC2CCCCO2
Level: 1
Mol. Weight: 943.09 g/mol
SMILES: C1CCCC2C1CCC(C2=3)C4C(CC3)C5C(CC4)CCCC5
Level: 0
Mol. Weight: 943.09 g/mol
SMILES: C1CCOCC1
Level: 0
Mol. Weight: 943.09 g/mol
No bioactivities available.
Absorption
- Caco-2 (logPapp)
- -6.23
- Human Oral Bioavailability 20%
- Non-Bioavailable
- Human Intestinal Absorption
- Non-Absorbed
- Madin-Darby Canine Kidney
- 3001.950
- Human Oral Bioavailability 50%
- Non-Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- 393199.51
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Non-Penetrable
- Fraction Unbound (Human)
- 0.950
- Plasma Protein Binding
- 88.15
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Non-Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Substrate
- OATP1B1
- Inhibitor
- OATP1B3
- Inhibitor
Excretion
- Clearance
- 0.590
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Toxic
- Bee
- Toxic
- Bioconcentration Factor
- -9140.860
- Biodegradation
- Safe
- Carcinogenesis
- Safe
- Crustacean
- Toxic
- Liver Injury I (DILI)
- Toxic
- Eye Corrosion
- Safe
- Eye Irritation
- Safe
- Maximum Tolerated Dose
- -0.780
- Liver Injury II
- Safe
- hERG Blockers
- Safe
- Daphnia Maga
- 4.050
- Micronucleos
- Toxic
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- -713637608.440
- Rat (Acute)
- 3.170
- Rat (Chronic Oral)
- 4.460
- Fathead Minnow
- 900822.650
- Respiratory Disease
- Safe
- Skin Sensitisation
- Toxic
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 80259782.520
- Hydration Free Energy
- -2.920
- Log(D) at pH=7.4
- -28.870
- Log(P)
- 1.19
- Log S
- -2.3
- Log(Vapor Pressure)
- -2642772.1
- Melting Point
- 281.77
- pKa Acid
- -19173.09
- pKa Basic
- -124.96
Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
---|---|---|---|---|---|
Acetylcholinesterase | P21836 | ACES_MOUSE | Mus musculus | 4 | 0.7889 |
Acetylcholinesterase | P21836 | ACES_MOUSE | Mus musculus | 4 | 0.7889 |
CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.7781 |
CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.7781 |