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(-)-silychristin

Family: Plantae - Cruciferae-Brassicaceea
Kingdom: Plantae
Class: Flavonoid

Canonical Smiles	OC[C@H]1c2cc(cc(c2O[C@@H]1c1ccc(c(c1)OC)O)O)[C@H]1Oc2cc(O)cc(c2C(=O)[C@@H]1O)O
InChI	InChI=1S/C25H22O10/c1-33-18-6-10(2-3-15(18)28)23-14(9-26)13-4-11(5-17(30)25(13)35-23)24-22(32)21(31)20-16(29)7-12(27)8-19(20)34-24/h2-8,14,22-24,26-30,32H,9H2,1H3/t14-,22-,23+,24+/m0/s1
InChIKey	BMLIIPOXVWESJG-KEDVUCMTSA-N
Formula	C₂₅H₂₂O₁₀
HBA	10
HBD	6
MW	482.44
Rotatable Bonds	4
TPSA	166.14
LogP	2.4
Number Rings	5
Number Aromatic Rings	3
Heavy Atom Count	35
Formal Charge	0
Fraction CSP3	0.24
Exact Mass	482.12
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Anastatica hierochuntica	Cruciferae-Brassicaceea	Plantae	663965

Showing of synonyms

Nakashima S, Matsuda H, et al. (2010). Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic and Medicinal Chemistry,2010,18(6),2337-2345. [View] [PubMed]

Pubchem: 12442785

Cas: 879325-58-3

Zinc: ZINC000013775871

Nmrshiftdb2: 60027021

Chembl: CHEMBL589325

Comptox: DTXSID80858723

Bindingdb: 50526627

No compound-protein relationship available.

SMILES: c1ccccc1C(C2)Oc(c23)ccc(c3)C(CC4=O)Oc(c45)cccc5

Level: 2

Mol. Weight: 482.44 g/mol

SMILES: C1COc(c12)ccc(c2)C(CC3=O)Oc(c34)cccc4

Level: 1

Mol. Weight: 482.44 g/mol

SMILES: c1cccc(c12)OC(C2)c3ccccc3

Level: 1

Mol. Weight: 482.44 g/mol

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 482.44 g/mol

SMILES: C1COc(c12)cccc2

Level: 0

Mol. Weight: 482.44 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 482.44 g/mol

Anticancer

Absorption

Caco-2 (logPapp): -6.59
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Non-Absorbed
Madin-Darby Canine Kidney: -5.310
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -0.18

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.030
Plasma Protein Binding: 87.59
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 13.160
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: -0.280
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.970
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.290
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -485.660
Rat (Acute): 2.470
Rat (Chronic Oral): 3.810
Fathead Minnow: 5.080
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 580.880
Hydration Free Energy: -3.100
Log(D) at pH=7.4: 2.570
Log(P): 1.53
Log S: -6.0
Log(Vapor Pressure): -9.85
Melting Point: 237.34
pKa Acid: 6.18
pKa Basic: 3.56

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9130
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9130
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9124
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9124
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8828
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8828
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8768
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8768
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8766
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8766
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8606
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8606
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8599
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8599
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8578
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8578
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8575
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8575
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8533
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8533
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8428
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8428
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8386
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8386
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8369
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8369
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8359
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8359
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8290
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8290
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8279
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8279
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8272
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8272
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8251
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8251
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8235
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8235
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8183
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8183
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.8162
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.8162
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	4	0.8151
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	4	0.8151
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8096
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8096
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8096
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8096
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8030
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8030
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.8027
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.8027
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7890
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7890
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7792
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7792
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.7775
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.7775
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7729
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7729
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7689
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7689
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7685
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7685
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7639
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7639
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7637
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7637
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7602
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7602
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8ZMF7	ISPF_SALTY	Salmonella typhimurium	4	0.7596
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8ZMF7	ISPF_SALTY	Salmonella typhimurium	4	0.7596
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7593
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7593
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.7577
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.7577
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7575
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7575
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7558
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7558
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7537
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7537
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7532
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7532
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7516
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7516
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7505
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7505
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7497
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7497
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.7478
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.7478
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7415
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7415
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7386
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7386
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7381
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7381
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7372
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7372
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7371
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7371
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7341
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7341
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	3	0.7331
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	3	0.7331
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7330
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7330
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	4	0.7299
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	4	0.7299
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7297
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7297
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7295
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7295
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7285
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7285
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7277
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7277
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7272
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7272
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7270
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7270
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7238
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7238
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7238
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7238
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7230
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7230
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7229
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7229
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7218
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7218
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7196
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7196
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7196
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7196
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7193
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7193
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7189
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7189
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7188
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7188
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7185
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7185
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7158
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7158
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7146
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7146
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7126
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7126
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7117
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7117
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7111
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7111
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7106
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7106
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7092
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7092
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.7090
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.7090
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.7090
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.7090
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7087
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7087
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7064
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7064
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7060
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7060
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7059
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7059
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.7056
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.7056
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7054
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7054
7-methylguanosine phosphate-specific 5'-nucleotidase	Q9W197	5NT3B_DROME	Drosophila melanogaster	3	0.7043
7-methylguanosine phosphate-specific 5'-nucleotidase	Q9W197	5NT3B_DROME	Drosophila melanogaster	3	0.7043
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7028
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7028
m7GpppX diphosphatase	Q96C86	DCPS_HUMAN	Homo sapiens	5	0.7025
m7GpppX diphosphatase	Q96C86	DCPS_HUMAN	Homo sapiens	5	0.7025
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7017
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7017
Transitional endoplasmic reticulum ATPase	P55072	TERA_HUMAN	Homo sapiens	3	0.7004
Transitional endoplasmic reticulum ATPase	P55072	TERA_HUMAN	Homo sapiens	3	0.7004

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