(+)-aromadendrin - Compound Card

(+)-aromadendrin

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(+)-aromadendrin

Structure
Zoomed Structure
  • Family: Plantae - Moraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles Oc1ccc(cc1)[C@H]1Oc2cc(O)cc(c2C(=O)[C@@H]1O)O
InChI InChI=1S/C15H12O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,14-18,20H/t14-,15+/m0/s1
InChIKey PADQINQHPQKXNL-LSDHHAIUSA-N
Formula C15H12O6
HBA 6
HBD 4
MW 288.25
Rotatable Bonds 1
TPSA 107.22
LogP 1.48
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 288.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Anastatica hierochuntica Cruciferae-Brassicaceea Plantae 663965
2 Anastatica hierochuntica Cruciferae-Brassicaceea Plantae 663965
3 Trilepisium madagascariense Moraceae Plantae 241931

Showing of synonyms

  • Yoshikawa M, Xu F, et al. (2003). Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica. Bioorganic and Medicinal Chemistry Letters,2003,13(6),1045-1049. [View] [PubMed]
  • Ango P, Kapche D, et al. (2012). Chemical constituents of Trilepisium madagascariense (Moraceae) and their antimicrobial activity. Phytochemistry Letters, 2012, 5(3), 524-528. [View]
  • Nakashima S, Matsuda H, et al. (2010). Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic and Medicinal Chemistry,2010,18(6),2337-2345. [View] [PubMed]
Pubchem: 122850
Kegg Ligand: C00974
Chebi: 15401
Nmrshiftdb2: 60022341
Metabolights: MTBLC15401
Chembl: CHEMBL9323
Bindingdb: 50240348
CPRiL: 68337
Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 288.25 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 288.25 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 288.25 g/mol

Anticancer
Hepatoprotective

Absorption

Caco-2 (logPapp)
-5.22
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.010
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.27

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.850
Plasma Protein Binding
77.88
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.490
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.510
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.990
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.510
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.020
Rat (Acute)
2.330
Rat (Chronic Oral)
2.990
Fathead Minnow
4.090
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
436.430
Hydration Free Energy
-11.150
Log(D) at pH=7.4
1.820
Log(P)
1.56
Log S
-3.16
Log(Vapor Pressure)
-7.91
Melting Point
236.07
pKa Acid
6.32
pKa Basic
4.88
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9422
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9422
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9333
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9333
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9332
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9332
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9328
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9328
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9215
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9215
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9176
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9176
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9120
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9120
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9119
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9119
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.9101
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.9101
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9096
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9096
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9089
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9089
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9057
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9057
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9026
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9026
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9008
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9008
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8944
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8944
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8944
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8944
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8939
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8939
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8922
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8922
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8914
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8914
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8913
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8913
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8910
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8910
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.8908
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.8908
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8903
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8903
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8841
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8841
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8836
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8836
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8827
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8827
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.8807
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.8807
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8797
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8797
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8785
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8785
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8759
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8759
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8751
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8751
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8741
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8741
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8688
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8688
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8649
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8649
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8634
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8634
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8620
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8620
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8606
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8606
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 5 0.8587
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 5 0.8587
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8586
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8586
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8569
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8569
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8542
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8542
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8524
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8524
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8515
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8515
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8483
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8483
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8460
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8460
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8450
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8450
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8446
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8446
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8433
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8433
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8426
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8426
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8407
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8407
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8385
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8385
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8374
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8374
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8351
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8351
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8335
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8335
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8326
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8326
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8304
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8304
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8276
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8276
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8254
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8254
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8250
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8250
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8218
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8218
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8187
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8187
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8181
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8181
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8139
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8139
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8130
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8130
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8109
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8109
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8108
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8108
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8090
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8090
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8082
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8082
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8066
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8066
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8042
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8042
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8008
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8008
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7913
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7913
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7906
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7906
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7904
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7904
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 5 0.7899
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 5 0.7899
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7871
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7871
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7869
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7869
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7840
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7840
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7835
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7835
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7823
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7823
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7819
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7819
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7810
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7810
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7802
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7802
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7774
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7774
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7770
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7770
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7769
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7769
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7753
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7753
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7742
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7742
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7738
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7738
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7686
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7686
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7681
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7681
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7635
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7635
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7598
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7598
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7591
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7591
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7590
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7590
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7575
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7575
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7564
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7564
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7561
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7561
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7555
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7555
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7553
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7553
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7541
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 5 0.7541
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7541
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 5 0.7541
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7532
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7532
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7531
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7531
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7519
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7519
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7459
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7459
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7444
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7444
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7433
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7433
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7426
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7426
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7422
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7422
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7421
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7421
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7412
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7412
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7411
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7411
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7397
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7397
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7392
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7392
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7388
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7388
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7328
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 4 0.7328
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7328
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 4 0.7328
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7320
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7320
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7316
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7316
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7309
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7309
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7299
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7299
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7297
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7297
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7281
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7281
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7279
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7279
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7272
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7272
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7267
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7267
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7265
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7265
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7259
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7259
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7248
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7248
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7238
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7238
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7234
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7234
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7233
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7233
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7226
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7226
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7210
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7210
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7205
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7205
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7199
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7199
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7188
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7188
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7175
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7175
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7172
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7172
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7170
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7170
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7162
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7162
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7161
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7161
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7150
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7150
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7143
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7143
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7122
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7122
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 4 0.7119
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 4 0.7119
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7118
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7118
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7092
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7092
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7088
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7088
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7086
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7086
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7077
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7077
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7070
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7070
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7070
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7070
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7067
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7067
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7064
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7064
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7056
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7056
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7042
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7042
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7038
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7038
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 4 0.7026
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 4 0.7026
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7002
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7002
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7002
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7002

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