(-)-evofolin B - Compound Card

(-)-evofolin B

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(-)-evofolin B

Structure
Zoomed Structure
  • Family: Plantae - Cruciferae-Brassicaceea
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles OC[C@@H](C(=O)c1ccc(c(c1)OC)O)c1ccc(c(c1)OC)O
InChI InChI=1S/C17H18O6/c1-22-15-7-10(3-5-13(15)19)12(9-18)17(21)11-4-6-14(20)16(8-11)23-2/h3-8,12,18-20H,9H2,1-2H3/t12-/m1/s1
InChIKey QMYGRGKKZBRZKH-GFCCVEGCSA-N
Formula C17H18O6
HBA 6
HBD 3
MW 318.33
Rotatable Bonds 6
TPSA 96.22
LogP 2.07
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 318.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Anastatica hierochuntica Cruciferae-Brassicaceea Plantae 663965

Showing of synonyms

  • Nakashima S, Matsuda H, et al. (2010). Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic and Medicinal Chemistry,2010,18(6),2337-2345. [View] [PubMed]
Pubchem: 46229015
Nmrshiftdb2: 60022937

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)Cc2ccccc2

Level: 1

Mol. Weight: 318.33 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 318.33 g/mol

Anticancer

Absorption

Caco-2 (logPapp)
-4.42
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.87
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.37

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.03
Plasma Protein Binding
62.6
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.01
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.91
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.17
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.23
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.37
Rat (Acute)
2.08
Rat (Chronic Oral)
2.99
Fathead Minnow
4.17
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
407.61
Hydration Free Energy
-9.0
Log(D) at pH=7.4
2.22
Log(P)
0.93
Log S
-4.05
Log(Vapor Pressure)
-7.21
Melting Point
145.7
pKa Acid
6.78
pKa Basic
3.56
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9848
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9848
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9689
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9689
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9352
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9352
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.9343
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.9343
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9341
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9341
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9330
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9330
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9173
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9173
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9133
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9133
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.9118
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.9118
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9081
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9081
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9020
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9020
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8956
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8956
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8935
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8935
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8902
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8902
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8830
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8830
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8757
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8757
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8734
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8734
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8715
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8715
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8668
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8668
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8666
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8666
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8635
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8635
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8616
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8616
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8601
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8601
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8600
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8600
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8564
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8564
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8560
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8560
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8506
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8506
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8498
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8498
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8494
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8494
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8494
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8494
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8483
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8483
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8480
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8480
Beta-glucosidase 1A Q25BW5 BGL1A_PHACH Phanerodontia chrysosporium 3 0.8463
Beta-glucosidase 1A Q25BW5 BGL1A_PHACH Phanerodontia chrysosporium 3 0.8463
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8445
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8445
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8437
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8437
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8436
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8436
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8427
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8427
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.8360
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.8360
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8337
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8337
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8321
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8321
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8317
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8317
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8311
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8311
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8271
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8271
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8269
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8269
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 4 0.8237
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 4 0.8237
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8223
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8223
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8190
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8190
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8182
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8182
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8171
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8171
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8169
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8169
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8156
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8156
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8151
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8151
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8118
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8118
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8113
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8113
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8110
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8110
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8098
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8098
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8088
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8088
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8087
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8087
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8086
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8086
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8078
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8078
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8064
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8064
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8060
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8060
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8045
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8045
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8020
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8020
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8018
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8018
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8012
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8012
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8009
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8009
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7993
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7993
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7991
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7991
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7989
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7989
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7979
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7979
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7971
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7971
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7963
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7963
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7947
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7947
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7933
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7933
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7919
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7919
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7904
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7904
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7898
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7898
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7884
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7884
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7882
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7882
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7879
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7879
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7862
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7862
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7844
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7844
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7796
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7796
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7789
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7789
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7786
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7786
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7782
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7782
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7763
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7763
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7735
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7735
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7725
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7725
Tubulin--tyrosine ligase F6Z895 A9ULH4_XENTR Xenopus tropicalis 4 0.7723
Tubulin--tyrosine ligase F6Z895 A9ULH4_XENTR Xenopus tropicalis 4 0.7723
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7717
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7717
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7715
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7715
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7706
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7706
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7697
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7697
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7694
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7694
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7686
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7686
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7665
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7665
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7656
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7656
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 4 0.7647
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 4 0.7647
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7646
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7646
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7635
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7635
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7613
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7613
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7607
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7607
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7605
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7605
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7592
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7592
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7592
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7592
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7568
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7568
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7551
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7551
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7551
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7551
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7550
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7550
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7550
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7550
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7547
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7547
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7544
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7544
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7540
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7540
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7540
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7540
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7540
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7540
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7537
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7537
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7532
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7532
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7532
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7532
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7527
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7527
L-aspartate semialdehyde sulfurtransferase Q57564 Y100_METJA Methanocaldococcus jannaschii 4 0.7524
L-aspartate semialdehyde sulfurtransferase Q57564 Y100_METJA Methanocaldococcus jannaschii 4 0.7524
Uncharacterized protein MJ1225 Q58622 Y1225_METJA Methanocaldococcus jannaschii 4 0.7522
Uncharacterized protein MJ1225 Q58622 Y1225_METJA Methanocaldococcus jannaschii 4 0.7522
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7512
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7512
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7508
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7508
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7495
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7495
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7492
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7492
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7489
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7489
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7485
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7485
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7482
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7482
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7464
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7464
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7460
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7460
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7444
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7444
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7442
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7442
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7437
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7437
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7436
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7436
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7434
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7434
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7432
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7432
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7428
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7428
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7424
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7424
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7424
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7424
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7413
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7413
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7407
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7407
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7404
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7404
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7397
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7397
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7381
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7381
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7379
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7379
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7377
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7377
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7362
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7362
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7359
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7359
GTPase KRas P01116 RASK_HUMAN Homo sapiens 4 0.7357
GTPase KRas P01116 RASK_HUMAN Homo sapiens 4 0.7357
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7354
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7354
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7353
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7353
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7352
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7352
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7317
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7317
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7316
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7316
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7311
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7311
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7308
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7308
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7306
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7306
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7302
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7302
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7292
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7292
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7286
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7286
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7284
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7284
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7282
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7282
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7276
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7276
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7276
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7276
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7273
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7273
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7269
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7269
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7268
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7268
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7267
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7267
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7265
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7265
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7257
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7257
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7255
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7255
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7251
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7251
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7248
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7248
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7247
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7247
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7245
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7245
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7244
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7244
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7244
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7244
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7240
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7240
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7240
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7240
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7239
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7239
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7235
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7235
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7230
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7230
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7220
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7220
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7217
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7217
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7207
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7207
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7206
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7206
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7205
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7205
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 4 0.7189
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 4 0.7189
Probable flavin-dependent thymidylate synthase O41156 THYX_PBCV1 Paramecium bursaria Chlorella virus 1 4 0.7186
Probable flavin-dependent thymidylate synthase O41156 THYX_PBCV1 Paramecium bursaria Chlorella virus 1 4 0.7186
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7182
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7182
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7180
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7180
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7179
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7179
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7170
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7170
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7164
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7164
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7161
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7161
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7156
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7156
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7154
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7154
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7150
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7150
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7137
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7137
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7135
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7135
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7134
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7134
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7129
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7129
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7124
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7124
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7124
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7124
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7123
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7123
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7117
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7117
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7116
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7116
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7116
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7116
Glutathione S-transferase P46088 GST_NOTSL Nototodarus sloanii 4 0.7112
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7112
Glutathione S-transferase P46088 GST_NOTSL Nototodarus sloanii 4 0.7112
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7112
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7107
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7107
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7106
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7106
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7104
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7104
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7096
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7096
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7096
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7096
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7094
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7094
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7094
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7094
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 3 0.7088
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 3 0.7088
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7087
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7087
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7085
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7085
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7080
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7080
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7080
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7080
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7079
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7079
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7078
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7078
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7078
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7078
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7077
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7077
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7077
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7077
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7076
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7076
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7076
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7076
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7075
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7075
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7072
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7072
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7065
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7065
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7064
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7064
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7059
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7059
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7059
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7059
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7055
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7055
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7050
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7050
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7041
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7041
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7037
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7037
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7036
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7036
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7030
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7030
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7030
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7030
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7027
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7027
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7027
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7027
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7025
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7025
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7024
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7024
GTP-binding nuclear protein Ran P62826 RAN_HUMAN Homo sapiens 5 0.7023
GTP-binding nuclear protein Ran P62826 RAN_HUMAN Homo sapiens 5 0.7023
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7022
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7022
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7020
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7020
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7019
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7019
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7016
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7016
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7013
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7013
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7009
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7009
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7005
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7005
Histone-lysine N-methyltransferase ASH1L Q9NR48 ASH1L_HUMAN Homo sapiens 4 0.7004
Histone-lysine N-methyltransferase ASH1L Q9NR48 ASH1L_HUMAN Homo sapiens 4 0.7004
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7002
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7002
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7000
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7000

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