1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]- 2-methoxyphenoxy}-1,3-propanediol - Compound Card

1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]- 2-methoxyphenoxy}-1,3-propanediol

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1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]- 2-methoxyphenoxy}-1,3-propanediol

Structure
Zoomed Structure
  • Family: Plantae - Cruciferae-Brassicaceea
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles OC/C=C/c1ccc(c(c1)OC)[C@](C(c1ccc(c(c1)OC)O)O)(CO)O
InChI InChI=1S/C20H24O7/c1-26-17-10-13(4-3-9-21)5-7-15(17)20(25,12-22)19(24)14-6-8-16(23)18(11-14)27-2/h3-8,10-11,19,21-25H,9,12H2,1-2H3/b4-3+/t19?,20-/m0/s1
InChIKey QPTMXJUPAZKGLJ-AARAPKBOSA-N
Formula C20H24O7
HBA 7
HBD 5
MW 376.41
Rotatable Bonds 8
TPSA 119.61
LogP 1.33
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.3
Exact Mass 376.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Anastatica hierochuntica Cruciferae-Brassicaceea Plantae 663965

Showing of synonyms

  • Nakashima S, Matsuda H, et al. (2010). Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic and Medicinal Chemistry,2010,18(6),2337-2345. [View] [PubMed]
Pubchem: 162817362
Nmrshiftdb2: 60027013

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CCc2ccccc2

Level: 1

Mol. Weight: 376.41 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 376.41 g/mol

Anticancer

Absorption

Caco-2 (logPapp)
-5.61
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.18
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-2.05

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.73
Plasma Protein Binding
42.67
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
11.53
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.7
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.8
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.22
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-5.23
Rat (Acute)
2.22
Rat (Chronic Oral)
3.68
Fathead Minnow
4.34
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
451.18
Hydration Free Energy
-11.29
Log(D) at pH=7.4
1.3
Log(P)
-0.07
Log S
-3.47
Log(Vapor Pressure)
-7.84
Melting Point
121.06
pKa Acid
7.83
pKa Basic
2.88
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9455
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9455
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9331
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9331
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.9330
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.9330
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9323
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9323
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9140
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9140
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9116
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9116
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9053
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9053
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9038
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9038
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9025
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9025
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9016
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9016
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8934
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8934
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8790
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8790
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8770
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8770
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8717
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8717
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8682
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8682
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8672
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8672
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8611
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8611
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8610
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8610
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8610
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8610
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.8550
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.8550
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 4 0.8548
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 4 0.8548
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8508
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8508
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8503
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8503
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8421
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8421
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8391
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8391
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8382
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8382
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8339
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8339
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8277
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8277
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8218
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8218
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 4 0.8174
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 4 0.8174
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8148
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8148
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8129
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8129
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8117
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8117
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8065
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8065
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8051
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8051
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7991
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7991
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7950
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7950
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7929
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7929
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7905
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7905
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7900
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7900
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7872
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7872
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7869
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7869
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7860
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7860
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7852
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7852
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7845
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7845
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7843
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7843
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7836
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7836
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7821
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7821
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7816
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7816
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7813
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7813
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7809
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7809
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7801
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7801
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 4 0.7774
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 4 0.7774
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7762
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7762
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7762
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7762
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7735
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7735
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 3 0.7668
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 3 0.7668
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7660
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7660
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7651
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7651
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7640
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7640
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7638
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7638
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7634
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7634
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7632
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7632
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7600
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7600
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7544
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7544
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7541
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7541
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7537
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7537
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7536
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7536
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7514
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7514
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7514
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7514
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7498
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7498
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7496
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7496
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7467
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7467
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7466
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7466
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.7459
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.7459
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7450
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7450
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7443
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7443
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7440
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7440
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7430
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7430
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7426
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7426
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7423
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7423
Spermidine synthase P19623 SPEE_HUMAN Homo sapiens 4 0.7416
Spermidine synthase P19623 SPEE_HUMAN Homo sapiens 4 0.7416
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7407
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7407
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7396
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7396
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.7387
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.7387
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7384
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7384
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7377
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7377
14-3-3 protein gamma P61981 1433G_HUMAN Homo sapiens 3 0.7375
14-3-3 protein gamma P61981 1433G_HUMAN Homo sapiens 3 0.7375
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7325
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7325
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7322
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7322
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7316
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7316
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7314
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7314
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7306
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7306
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7301
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7301
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7289
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7289
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7283
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7283
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7273
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7273
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7265
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7265
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 4 0.7258
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 4 0.7258
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7244
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7244
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7242
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7242
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7239
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7239
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7227
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7227
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7227
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7227
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7220
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7220
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7214
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7214
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7212
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7212
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7208
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7208
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7208
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7208
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7205
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7205
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7203
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7188
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7188
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7178
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7178
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7174
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7174
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7164
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7164
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7161
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7161
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7160
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7160
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7138
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7138
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7134
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7134
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7128
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7128
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7124
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7124
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7115
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7115
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7106
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7106
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7105
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7105
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7103
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7103
Glutathione S-transferase P46088 GST_NOTSL Nototodarus sloanii 4 0.7092
Glutathione S-transferase P46088 GST_NOTSL Nototodarus sloanii 4 0.7092
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7092
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7092
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7080
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7080
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7065
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7065
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7054
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7054
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7052
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7052
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7050
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7050
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7049
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7049
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7046
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7046
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7036
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7036
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7032
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7032
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7031
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7031
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7025
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7025
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7017
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7017
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7017
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7017
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7008
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7008
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7003
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7003

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