1-(4-hydroxy- 3-methoxyphenyl)-2-{4-[2-formyl-(E)-vinyl]-2-methoxyphenoxy}-1,3-propanediol - Compound Card

1-(4-hydroxy- 3-methoxyphenyl)-2-{4-[2-formyl-(E)-vinyl]-2-methoxyphenoxy}-1,3-propanediol

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1-(4-hydroxy- 3-methoxyphenyl)-2-{4-[2-formyl-(E)-vinyl]-2-methoxyphenoxy}-1,3-propanediol

Structure
Zoomed Structure
  • Family: Plantae - Cruciferae-Brassicaceea
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles O=C/C=C/c1ccc(c(c1)OC)[C@](C(c1ccc(c(c1)OC)O)O)(CO)O
InChI InChI=1S/C20H22O7/c1-26-17-10-13(4-3-9-21)5-7-15(17)20(25,12-22)19(24)14-6-8-16(23)18(11-14)27-2/h3-11,19,22-25H,12H2,1-2H3/b4-3+/t19?,20-/m0/s1
InChIKey QBFAVXCSZOANGN-AARAPKBOSA-N
Formula C20H22O7
HBA 7
HBD 4
MW 374.39
Rotatable Bonds 8
TPSA 116.45
LogP 1.53
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 374.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Anastatica hierochuntica Cruciferae-Brassicaceea Plantae 663965

Showing of synonyms

  • Nakashima S, Matsuda H, et al. (2010). Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic and Medicinal Chemistry,2010,18(6),2337-2345. [View] [PubMed]
Pubchem: 162925135
Nmrshiftdb2: 60027024

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CCc2ccccc2

Level: 1

Mol. Weight: 374.39 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 374.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.31
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.97
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.45

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.57
Plasma Protein Binding
43.61
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.54
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-1.08
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.91
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.98
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-3.14
Rat (Acute)
2.21
Rat (Chronic Oral)
3.49
Fathead Minnow
4.75
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
444.6
Hydration Free Energy
-11.21
Log(D) at pH=7.4
1.6
Log(P)
-0.06
Log S
-3.45
Log(Vapor Pressure)
-7.82
Melting Point
119.1
pKa Acid
7.25
pKa Basic
2.03
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9450
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9450
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9326
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9326
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9175
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9175
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9171
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9171
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9131
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9131
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9129
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9129
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9085
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9085
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9074
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9074
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9024
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9024
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.9019
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.9019
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8907
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8907
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8904
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8904
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8799
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8799
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8787
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8787
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8681
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8681
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8663
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8663
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8615
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8615
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8592
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8592
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8581
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8581
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8577
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8577
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 4 0.8497
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 4 0.8497
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8488
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8488
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8462
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8462
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8412
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8412
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.8397
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.8397
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8365
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8365
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 4 0.8302
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 4 0.8302
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 4 0.8286
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 4 0.8286
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8282
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8282
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.8276
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.8276
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8215
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8215
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8197
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8197
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.8177
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.8177
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8168
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8168
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8157
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8157
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8130
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8130
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8109
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8109
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8081
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8081
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8064
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8064
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7974
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7974
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 4 0.7962
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 4 0.7962
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7957
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7957
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7940
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7940
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7913
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7913
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7912
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7912
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7898
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7898
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7893
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7893
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7885
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7885
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7878
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7878
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7849
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7849
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7847
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7847
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7820
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7820
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.7817
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.7817
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7779
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7779
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7772
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7772
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7755
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7755
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7740
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7740
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7726
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7726
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7721
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7721
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7706
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7706
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7704
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7704
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7650
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7650
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7631
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7631
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7613
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7613
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7602
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7602
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7599
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7599
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7595
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7595
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7576
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7576
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7572
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7572
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7570
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7570
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7562
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7562
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7560
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7560
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7552
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7552
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7545
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7545
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7534
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7534
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7530
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7530
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7529
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7529
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7524
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7524
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7510
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7510
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7508
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7508
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7505
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7505
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7489
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7489
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7480
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7480
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7479
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7479
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7435
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7435
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7427
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7427
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7418
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7418
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7408
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7408
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7405
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7405
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7403
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7403
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7380
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7380
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7380
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7380
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7380
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7380
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7374
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7374
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7370
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7370
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7368
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7368
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7367
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7367
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7364
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7364
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7358
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7358
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7355
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7355
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7355
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7355
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7342
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7342
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7333
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7333
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7332
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7332
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7329
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7329
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7327
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7327
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7324
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7324
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7320
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7320
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7319
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7319
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7313
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7313
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7312
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7312
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7312
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7312
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7311
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7311
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7301
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7301
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7298
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7298
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7289
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7289
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7289
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7289
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7287
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7287
Glutathione S-transferase P46088 GST_NOTSL Nototodarus sloanii 4 0.7280
Glutathione S-transferase P46088 GST_NOTSL Nototodarus sloanii 4 0.7280
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7271
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7271
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7266
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7266
Beta-glucosidase 1A Q25BW5 BGL1A_PHACH Phanerodontia chrysosporium 3 0.7254
Beta-glucosidase 1A Q25BW5 BGL1A_PHACH Phanerodontia chrysosporium 3 0.7254
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7244
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7244
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7244
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7244
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7235
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7235
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7233
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7233
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7230
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7230
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7227
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7227
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7225
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7225
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7223
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7223
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7220
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7220
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.7216
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.7216
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7212
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7212
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7212
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7212
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7211
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7211
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7209
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7209
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7205
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7205
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7186
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7186
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7184
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7184
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7178
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7178
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7167
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7167
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7166
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7166
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7157
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7157
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7156
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7156
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7149
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7149
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7149
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7149
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7143
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7143
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.7135
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.7135
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7126
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7126
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7123
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7123
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 4 0.7104
Aldos-2-ulose dehydratase P84193 AUD_PHACH Phanerodontia chrysosporium 3 0.7104
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 4 0.7104
Aldos-2-ulose dehydratase P84193 AUD_PHACH Phanerodontia chrysosporium 3 0.7104
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7103
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7103
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7097
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7097
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7091
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7091
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7081
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7081
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7081
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7081
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7080
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7080
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7072
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7072
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7069
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7069
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7066
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7066
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7064
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7064
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7058
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7058
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7044
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7044
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7037
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7037
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7036
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7036
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7028
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7028
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7024
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7024
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7022
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7022
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7022
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7022
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7021
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7021
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7018
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7018
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7010
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7010
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7000
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7000

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