2,4'-dihydroxy-3'-methoxyacetophenone - Compound Card

2,4'-dihydroxy-3'-methoxyacetophenone

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2,4'-dihydroxy-3'-methoxyacetophenone

Structure
Zoomed Structure
  • Family: Plantae - Cruciferae-Brassicaceea
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles OCC(=O)c1ccc(c(c1)OC)O
InChI InChI=1S/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-4,10-11H,5H2,1H3
InChIKey QNMANLUEFQNQCX-UHFFFAOYSA-N
Formula C9H10O4
HBA 4
HBD 2
MW 182.17
Rotatable Bonds 3
TPSA 66.76
LogP 0.58
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 13
Formal Charge 0
Fraction CSP3 0.22
Exact Mass 182.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Anastatica hierochuntica Cruciferae-Brassicaceea Plantae 663965

Showing of synonyms

  • Nakashima S, Matsuda H, et al. (2010). Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic and Medicinal Chemistry,2010,18(6),2337-2345. [View] [PubMed]
Pubchem: 87530
Nmrshiftdb2: 60027015

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 182.17 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.44
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.26
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.77

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.45
Plasma Protein Binding
15.95
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.89
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.41
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.19
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
3.86
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.95
Rat (Acute)
1.96
Rat (Chronic Oral)
2.52
Fathead Minnow
3.84
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
302.85
Hydration Free Energy
-11.93
Log(D) at pH=7.4
0.19
Log(P)
0.29
Log S
-1.34
Log(Vapor Pressure)
-4.02
Melting Point
126.66
pKa Acid
7.35
pKa Basic
3.61
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9585
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9585
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9406
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9406
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9405
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9405
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9321
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9321
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9266
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9266
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9191
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9191
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9172
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9172
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9124
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9124
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9087
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9087
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9081
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9081
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8959
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8959
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8958
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8958
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8932
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8932
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8925
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8925
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8917
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8917
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8905
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8905
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8898
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8898
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8884
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8884
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8864
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8864
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8816
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8816
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 3 0.8798
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 3 0.8798
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8779
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8779
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8755
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8755
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8747
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8747
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8729
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8729
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8724
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8724
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8708
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8708
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8551
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8551
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8547
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8547
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8538
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8538
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8528
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8528
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.8519
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.8519
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8515
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8515
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8508
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8508
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.8476
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.8476
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8463
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8463
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8450
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8450
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8419
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8419
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8417
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8417
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8416
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8416
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8415
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8415
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8410
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8410
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8392
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8392
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8345
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8345
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8313
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8313
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.8298
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.8298
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8243
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8243
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8241
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8241
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.8237
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.8237
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8175
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8175
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8157
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8157
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.8143
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.8143
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8125
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8125
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8090
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8090
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8084
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8084
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8047
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8047
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7972
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7972
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7926
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7926
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7915
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7915
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7858
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7858
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7827
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7827
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7821
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7821
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7795
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7795
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7670
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7670
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 3 0.7618
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 3 0.7618
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7607
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7607
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7584
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7584
Lactose operon repressor P03023 LACI_ECOLI Escherichia coli 3 0.7555
Lactose operon repressor P03023 LACI_ECOLI Escherichia coli 3 0.7555
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7537
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7537
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7535
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7535
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.7531
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.7531
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7528
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7528
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7522
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7522
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7501
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7501
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7488
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7488
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7487
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7487
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7469
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7469
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7468
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7468
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7455
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7455
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7452
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7452
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7444
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7444
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7411
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7411
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7400
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7400
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7397
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7397
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7395
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7395
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7390
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7390
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 4 0.7388
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 4 0.7388
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7375
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7375
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7367
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7367
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7363
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7363
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7355
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7355
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7350
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7350
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7348
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7348
Beta-glucosidase 1A Q25BW5 BGL1A_PHACH Phanerodontia chrysosporium 3 0.7339
Beta-glucosidase 1A Q25BW5 BGL1A_PHACH Phanerodontia chrysosporium 3 0.7339
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7330
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7330
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7322
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7322
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7310
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7310
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7298
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7298
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7285
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7285
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7272
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7272
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7266
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7266
ADP-ribose glycohydrolase AF_1521 O28751 Y1521_ARCFU Archaeoglobus fulgidus 4 0.7262
ADP-ribose glycohydrolase AF_1521 O28751 Y1521_ARCFU Archaeoglobus fulgidus 4 0.7262
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7256
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7256
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7251
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7251
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7249
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7249
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7249
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7249
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7242
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7242
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7237
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7237
Adenylosuccinate synthetase isozyme 1 P28650 PURA1_MOUSE Mus musculus 4 0.7233
Adenylosuccinate synthetase isozyme 1 P28650 PURA1_MOUSE Mus musculus 4 0.7233
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7229
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7229
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7225
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7225
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7219
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7219
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7210
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7210
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7210
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7210
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7208
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7208
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7206
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7206
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7203
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7203
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7198
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7198
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7195
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7195
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7187
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7187
Vanillyl-alcohol oxidase P56216 VAOX_PENSI Penicillium simplicissimum 3 0.7183
Vanillyl-alcohol oxidase P56216 VAOX_PENSI Penicillium simplicissimum 3 0.7183
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7174
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7174
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7171
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7171
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7170
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7170
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7164
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7164
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7160
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7160
tRNA (guanine-N(1)-)-methyltransferase Q2GIL5 TRMD_ANAPZ Anaplasma phagocytophilum 3 0.7155
tRNA (guanine-N(1)-)-methyltransferase Q2GIL5 TRMD_ANAPZ Anaplasma phagocytophilum 3 0.7155
Adenine DNA glycosylase P83847 MUTY_GEOSE Geobacillus stearothermophilus 3 0.7148
Adenine DNA glycosylase P83847 MUTY_GEOSE Geobacillus stearothermophilus 3 0.7148
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7141
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7141
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7137
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7137
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7131
Rho family GTPase C4M4W4 C4M4W4_ENTHI Entamoeba histolytica 4 0.7131
Rho family GTPase C4M4W4 C4M4W4_ENTHI Entamoeba histolytica 4 0.7131
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7131
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7129
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7129
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7126
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7126
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7125
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7125
Chromosomal replication initiator protein DnaA P46798 DNAA_THEMA Thermotoga maritima 3 0.7121
Chromosomal replication initiator protein DnaA P46798 DNAA_THEMA Thermotoga maritima 3 0.7121
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7106
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7106
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 3 0.7099
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7099
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 3 0.7099
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7099
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7098
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7098
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7085
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7085
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7076
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7076
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7073
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7073
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7070
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7070
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7066
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7066
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7065
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7065
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7062
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7062
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7061
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7061
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7053
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7053
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7051
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7051
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7051
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7051
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7051
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7051
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7043
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7043
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7041
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7041
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7039
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7039
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7037
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7037
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7025
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7025
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7013
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7013
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7013
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7013
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase Q8U0R7 PURP_PYRFU Pyrococcus furiosus 3 0.7011
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase Q8U0R7 PURP_PYRFU Pyrococcus furiosus 3 0.7011
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7007
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7007
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7006
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7006
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7005
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7005

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