Chrysin - Compound Card

Chrysin

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Chrysin

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae, Animalia
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles Oc1cc(O)c2c(c1)oc(cc2=O)c1ccccc1
InChI InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
InChIKey RTIXKCRFFJGDFG-UHFFFAOYSA-N
Formula C15H10O4
HBA 4
HBD 2
MW 254.24
Rotatable Bonds 1
TPSA 70.67
LogP 2.87
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 254.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Atractylis flava Asteraceae Plantae 41483
2 Apis species Apidae Animalia 7459
3 Apis species Apidae Animalia 7459
4 Apis mellifica Apidae Animalia 7460
5 Centaurea omphalotricha Asteraceae Plantae 41503
6 Millettia leucantha Leguminosae/Fabaceae Plantae 1712206
7 Sphaerocoryne gracilis Annonaceae Plantae 489348

Showing of synonyms

  • Derese S, Barasa L, et al. (2014). 4'-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species.. Phytochemistry Letters,2014,31(8),69-72. [View] [PubMed]
  • Maeda G, Munissi JJE, et al. (2020). A Meroisoprenoid, Heptenolides, and C‐Benzylated Flavonoids from Sphaerocoryne gracilis ssp. Gracilis. Journal of natural products,2020, 83(2), 316-322. [View] [PubMed]
  • Boufadi YM, Soubhye J, et al. (2014). Characterization and antioxidant properties of six Algerian propolis extracts: ethyl acetate extracts inhibit myeloperoxidase activity. International Journal of Molecular Sciences,2014,15(2),2327-2345. [View] [PubMed]
  • Piccinelli AL, Mencherini T, et al. (2013). Chemical composition and antioxidant activity of Algerian propolis. Journal of Agricultural and Food Chemistry,2013,61(21),5080-5088. [View] [PubMed]
  • Mouffok S, Haba H, et al. (2012). Chemical constituents of Centaurea omphalotricha Coss. & Durieu ex Batt. & Trab.. Records of Natural Products,2012,6(3),292-295. [View]
  • Chabani S, Haba H, et al. (2013). Flavonoid glycosides and triterpenoids from Atractylis flava.. Phytochemistry Letters,2013,6,9-13. [View]
  • Segueni N, Zellagui A, et al. (2016). Flavonoids from Algerian propolis. Arabian Journal of Chemistry,2016,9,S425-S428. [View]
Pubchem: 5281607
Kegg Ligand: C10028
Chebi: 75095
Nmrshiftdb2: 60022375
Metabolights: MTBLC75095
Chembl: CHEMBL117
Drugbank: DB15581
Pdb Ligand: 57D
Bindingdb: 7461
Selleck: Chrysin
CPRiL: 31524
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 254.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 254.24 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 254.24 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-4.86
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.73
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.7

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.87
Plasma Protein Binding
87.53
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.05
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.46
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.44
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.87
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.84
Rat (Acute)
2.16
Rat (Chronic Oral)
2.51
Fathead Minnow
4.55
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
431.91
Hydration Free Energy
-12.24
Log(D) at pH=7.4
3.8
Log(P)
3.56
Log S
-4.64
Log(Vapor Pressure)
-8.5
Melting Point
252.19
pKa Acid
6.29
pKa Basic
6.53
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9778
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9778
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9708
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9708
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9656
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9656
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9556
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9556
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9551
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9551
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9519
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9519
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9470
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9470
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.9456
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.9456
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9397
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9397
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9275
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9275
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9271
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9271
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9259
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9259
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.9254
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.9254
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9231
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9231
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9229
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9229
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9181
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9181
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9158
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9158
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9122
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9122
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9053
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9053
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9048
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9048
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8980
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8980
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8965
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8965
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8951
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8951
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8949
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8949
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8947
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8947
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8931
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8931
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8919
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8919
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8906
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8906
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8871
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8871
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8851
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8851
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8850
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8850
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8844
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8844
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8825
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8825
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8816
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8816
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8813
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8813
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8804
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8804
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8770
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8770
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8767
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8767
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8748
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8748
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8744
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8744
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8715
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8715
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8682
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8682
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8681
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8681
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8673
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8673
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8657
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8657
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8628
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8628
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8597
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8597
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8592
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8592
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8572
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8572
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8559
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8559
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8554
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8554
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8541
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8541
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8527
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8527
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8511
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8511
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8479
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8479
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8462
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8462
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8453
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8453
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8441
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8441
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8436
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8436
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8414
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8414
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8393
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8393
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8365
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8365
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8335
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8335
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8329
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8329
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8317
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8317
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8303
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8303
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8294
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8294
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8291
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8291
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8261
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8261
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8242
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8242
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8202
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8202
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8192
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8192
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8184
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8184
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8168
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8168
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8161
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8161
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8155
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8155
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8110
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8110
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8098
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8098
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8086
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8086
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8073
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8073
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8062
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8062
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8026
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8026
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7995
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7995
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7988
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7988
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7982
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7982
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7975
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7975
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7941
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7941
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7935
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7935
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7923
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7923
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7905
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7905
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7902
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7902
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7875
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7875
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7873
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7873
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7872
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7872
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7849
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7849
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7844
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7844
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7843
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7843
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7827
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7827
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7824
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7824
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7777
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7777
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7754
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7754
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7752
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7752
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7735
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7735
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7726
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7726
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7720
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7720
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7720
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7720
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7719
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7719
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7688
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7688
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7687
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7687
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7673
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7673
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7670
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7670
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7641
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7641
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7636
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7636
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7628
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7628
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7627
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7627
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7615
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7615
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7614
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7614
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7613
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7613
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7608
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7608
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7593
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7593
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7592
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7592
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7587
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7587
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7579
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7579
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7575
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7575
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7569
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7569
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7568
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7568
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7552
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7552
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7550
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7550
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7549
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7549
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7539
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7539
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7528
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7528
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7527
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7527
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7526
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7526
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7517
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7517
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7517
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7517
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7516
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7516
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7514
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7514
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7510
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7510
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7501
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7501
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7494
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7494
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7488
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7488
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7488
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7488
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7483
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7483
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7469
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7469
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7462
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7462
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7461
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7461
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7445
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7445
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7432
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7432
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7430
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7430
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7428
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7428
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7427
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7427
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7421
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7421
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7416
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7416
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7413
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7413
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7403
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7403
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7403
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7403
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7401
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7401
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7391
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7391
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7387
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7387
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7386
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7386
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7381
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7381
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7376
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7376
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7363
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7363
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7353
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7353
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7350
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7350
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7349
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7349
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7346
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7346
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7341
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7341
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7339
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7339
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 4 0.7329
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 4 0.7329
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7329
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7329
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7327
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7327
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7326
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7326
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7326
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7326
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7324
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7324
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7320
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7320
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7316
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7316
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7315
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7315
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7313
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7313
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7309
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7309
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7295
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7295
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7292
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7292
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7289
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7289
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7287
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7287
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7283
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7283
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7283
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7283
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7281
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7281
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7277
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7277
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7271
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7271
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7270
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7270
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7251
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7251
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7251
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7251
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7243
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7243
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7240
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7240
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7238
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7238
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7235
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7235
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7235
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7235
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7234
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7234
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7232
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7232
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7231
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7231
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7231
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7231
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 3 0.7231
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 3 0.7231
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7228
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7228
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7228
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7228
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7227
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7227
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7221
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7221
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7218
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7218
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7205
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7205
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7199
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7199
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7199
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7199
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7193
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7193
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7187
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7187
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 4 0.7186
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 4 0.7186
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7180
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7180
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7169
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7169
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7160
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7160
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7158
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7158
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7156
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7156
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7148
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7148
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7147
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7147
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7141
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7141
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7139
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7139
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7138
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7138
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7137
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7137
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7130
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7130
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7122
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7122
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7118
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7118
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7117
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7117
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7117
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7117
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7115
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7115
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7110
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7110
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7110
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7110
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7104
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7104
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7103
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7103
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7097
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7097
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7097
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7097
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7095
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7095
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7093
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7093
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7083
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7083
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7080
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7080
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7079
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7079
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7077
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7077
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7076
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7076
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7074
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7074
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7070
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7070
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7068
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7068
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7062
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7062
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7060
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7060
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7048
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7048
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7047
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7047
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7042
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7042
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7039
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7039
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7027
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7027
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7024
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7024
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7021
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7021
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7016
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7016
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7015
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7015
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7015
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7015
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7013
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7013
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7009
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7009
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7007
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7007
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7006
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7006
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7005
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7005

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