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3,4-dimethyl cinnoline

Family: Plantae - Asteraceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Cinnoline Alkaloid

Canonical Smiles	Cc1nnc2c(c1C)cccc2
InChI	InChI=1S/C10H10N2/c1-7-8(2)11-12-10-6-4-3-5-9(7)10/h3-6H,1-2H3
InChIKey	FNBCNZVYOVGSRD-UHFFFAOYSA-N
Formula	C₁₀H₁₀N₂
HBA	2
HBD	0
MW	158.2
Rotatable Bonds	0
TPSA	25.78
LogP	2.25
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	12
Formal Charge	0
Fraction CSP3	0.2
Exact Mass	158.08
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Artemisia arborescens	Asteraceae	Plantae	72386

Showing of synonyms

Abderrahim A, Belhamel K, et al. (2010). Chemical composition of the essential oil from Artemisia arborescens L. growing wild in Algeria.. Records of Natural Products,2010,4(1),87-90. [View]

Pubchem: 594068

Cas: 3929-83-7

Zinc: ZINC000032197210

Comptox: DTXSID20344039

No compound-protein relationship available.

SMILES: c1cnnc(c12)cccc2

Level: 0

Mol. Weight: 158.2 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.22
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -3.68
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.09

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.7
Plasma Protein Binding: 55.52
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.88
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.8
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.28
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.02
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.29
Rat (Acute): 2.19
Rat (Chronic Oral): 1.78
Fathead Minnow: 4.31
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 263.02
Hydration Free Energy: -6.97
Log(D) at pH=7.4: 2.53
Log(P): 1.62
Log S: -1.82
Log(Vapor Pressure): -3.06
Melting Point: 80.91
pKa Acid: 11.86
pKa Basic: 4.1

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9241
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9241
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.9136
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.9136
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.9014
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.9014
Probable esterase KAI2	Q9SZU7	KAI2_ARATH	Arabidopsis thaliana	3	0.8918
Probable esterase KAI2	Q9SZU7	KAI2_ARATH	Arabidopsis thaliana	3	0.8918
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8838
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8838
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8821
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8821
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8652
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8652
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8645
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8645
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8641
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8641
Caspase-7	P55210	CASP7_HUMAN	Homo sapiens	3	0.8604
Caspase-7	P55210	CASP7_HUMAN	Homo sapiens	3	0.8604
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8533
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8533
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8500
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8500
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8480
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8480
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8174
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8174
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7996
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7996
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7976
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7976
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7973
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7973
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7972
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7972
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7962
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7962
Albumin	P02769	ALBU_BOVIN	Bos taurus	3	0.7958
Albumin	P02769	ALBU_BOVIN	Bos taurus	3	0.7958
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7956
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7956
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7918
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7918
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7912
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7912
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7850
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7850
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	3	0.7842
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	3	0.7842
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	2	0.7835
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	2	0.7835
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7810
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7810
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7808
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7808
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7802
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	3	0.7802
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	3	0.7802
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7802
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	2	0.7798
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	2	0.7798
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7782
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7782
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7725
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7725
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7721
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7721
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7700
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7700
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7697
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7697
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7695
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7695
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7691
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7691
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7681
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7681
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7671
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7671
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7659
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7659
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7646
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7646
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	2	0.7632
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	2	0.7632
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7627
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7627
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	2	0.7585
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	2	0.7585
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7584
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7584
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7581
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7581
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	3	0.7563
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	3	0.7563
Fatty acid-binding protein, adipocyte	P15090	FABP4_HUMAN	Homo sapiens	2	0.7533
Fatty acid-binding protein, adipocyte	P15090	FABP4_HUMAN	Homo sapiens	2	0.7533
Jasmonoyl--L-amino acid synthetase JAR1	Q9SKE2	JAR1_ARATH	Arabidopsis thaliana	3	0.7528
Jasmonoyl--L-amino acid synthetase JAR1	Q9SKE2	JAR1_ARATH	Arabidopsis thaliana	3	0.7528
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7510
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7510
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7503
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7503
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7488
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7488
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	2	0.7466
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	2	0.7466
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7447
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7447
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7437
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7437
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7430
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7430
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7424
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7424
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7378
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7378
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7378
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7378
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7373
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7373
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7338
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7338
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7332
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7332
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	2	0.7331
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	2	0.7331
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7328
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7328
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7320
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7320
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7320
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7320
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	3	0.7317
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	3	0.7317
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7316
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7316
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7313
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7313
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7311
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7311
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7308
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7308
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7297
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7297
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7293
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7293
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7283
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7283
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7260
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7260
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7248
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7248
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7233
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7233
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7224
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7224
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7224
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7224
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7221
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7221
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7211
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7211
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7208
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7208
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7203
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7203
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	2	0.7194
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	2	0.7194
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7191
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7191
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7187
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7187
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7186
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7186
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7181
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7181
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7175
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7175
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7142
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7142
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	2	0.7140
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	2	0.7140
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7136
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7136
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7129
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7129
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7122
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7122
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7107
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7107
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7088
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7088
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7088
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7088
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7078
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7078
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7071
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7071
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7071
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7071
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7059
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7059
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7053
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7053
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7022
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7022
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7005
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7005

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