Eupatilin 7-methyl ether - Compound Card

Eupatilin 7-methyl ether

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Eupatilin 7-methyl ether

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone Aglycone
Canonical Smiles COc1ccc(cc1OC)C1=CC(=O)c2c(C1)cc(c(c2O)OC)OC
InChI InChI=1S/C20H20O6/c1-23-15-6-5-11(9-16(15)24-2)12-7-13-10-17(25-3)20(26-4)19(22)18(13)14(21)8-12/h5-6,8-10,22H,7H2,1-4H3
InChIKey YGJMHGKNTSIVBA-UHFFFAOYSA-N
Formula C20H20O6
HBA 6
HBD 1
MW 356.37
Rotatable Bonds 5
TPSA 74.22
LogP 3.25
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 356.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Achillea santolina Asteraceae Plantae 1028379

Showing of synonyms

  • Balboul BAAA, Ahmed AA, et al. (1997). A guaianolide and a germacranolide from Achillea santolina.. Phytochemistry,1997,46(6),1045-1049. [View]
Pubchem: 162943410
Nmrshiftdb2: 60073255

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)CC(=CC2=O)c3ccccc3

Level: 1

Mol. Weight: 356.37 g/mol

Structure

SMILES: c1cccc(c12)CC=CC2=O

Level: 0

Mol. Weight: 356.37 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 356.37 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.64
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.680
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.53

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.100
Plasma Protein Binding
51.67
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.310
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.950
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.290
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.880
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.600
Rat (Acute)
2.300
Rat (Chronic Oral)
2.710
Fathead Minnow
4.900
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
431.340
Hydration Free Energy
-8.090
Log(D) at pH=7.4
3.120
Log(P)
3.35
Log S
-4.5
Log(Vapor Pressure)
-7.05
Melting Point
154.78
pKa Acid
7.37
pKa Basic
3.0
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9593
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9593
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9408
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9408
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9386
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9386
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9362
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9362
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9327
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9327
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9321
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9321
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9248
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9248
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9237
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9237
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9231
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9231
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9185
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9185
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9166
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9166
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9131
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9131
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9114
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9114
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9099
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9099
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9082
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9082
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9074
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9074
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9059
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9059
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8913
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8913
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8846
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8846
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8825
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8825
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8765
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8765
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8758
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8758
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8689
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8689
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8599
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8599
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 4 0.8557
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 4 0.8557
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8522
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8522
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8462
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8462
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8450
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8450
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8393
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8393
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8382
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8382
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8372
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8372
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8340
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8340
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8302
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8302
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8260
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8260
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8243
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8243
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8233
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8233
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8164
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8164
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8128
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8128
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8090
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8090
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8083
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8083
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8069
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8069
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.8037
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.8037
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8027
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8027
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8005
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8005
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7958
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7958
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7950
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7950
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7939
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7939
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7898
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7898
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7893
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7893
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7825
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7825
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7824
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7824
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7821
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7821
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7819
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7819
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7816
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7816
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7788
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7788
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7767
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7767
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7761
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7761
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7754
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7754
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7739
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7739
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7725
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7725
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7716
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7716
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7715
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7715
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7714
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7714
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7709
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7709
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7699
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7699
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7697
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7697
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7697
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7697
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7697
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7697
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7684
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7684
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7656
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7656
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7648
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7648
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7647
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7647
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7645
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7645
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7644
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7644
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7606
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7606
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7589
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7589
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7573
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7573
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7571
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7571
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7565
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7565
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7553
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7553
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7551
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7551
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7549
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7549
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7544
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7544
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7540
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7540
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7539
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7539
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7528
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7528
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7519
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7519
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7509
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7509
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7497
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7497
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7476
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7476
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7475
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7475
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7473
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7473
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7463
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7463
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7462
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7462
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7431
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7431
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7427
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7427
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7421
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7421
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7413
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7413
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7408
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7408
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7408
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7408
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7407
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7407
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7398
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7398
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7393
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7393
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7385
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7385
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7367
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7367
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7350
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7350
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7350
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7350
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7344
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7344
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7337
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7337
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7336
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7336
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7333
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7333
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7330
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7330
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7330
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7330
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7322
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7322
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7276
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7276
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7275
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7275
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7272
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7272
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7271
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7271
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7264
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7264
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7263
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7263
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7259
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7259
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7258
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7258
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7239
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7239
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7232
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7232
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7218
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7218
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7215
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7215
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7212
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7212
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7203
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7203
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 3 0.7182
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 3 0.7182
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7176
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7176
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7176
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7176
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7167
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7167
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7163
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7163
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7161
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7161
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7157
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7157
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7151
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7151
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7139
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7139
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7126
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7126
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7124
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7124
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7110
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7110
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7094
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7094
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7093
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7093
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7093
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7093
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7091
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7091
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7087
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7087
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7076
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7076
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7072
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7072
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7071
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7071
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7067
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7067
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7064
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7064
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7056
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7056
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7053
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7053
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7045
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7045
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7042
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7042
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7039
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7039
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7038
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7038
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7034
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7034
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7033
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7033
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7021
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7021
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7016
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7016
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7012
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7012
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7009
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7009
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7004
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7004
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7002
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7002

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