5,7-dihydroxy-3,4'-dimethoxyflavone - Compound Card

5,7-dihydroxy-3,4'-dimethoxyflavone

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5,7-dihydroxy-3,4'-dimethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Rubiaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles COc1ccc(cc1)c1oc2cc(O)cc(c2c(=O)c1OC)O
InChI InChI=1S/C17H14O6/c1-21-11-5-3-9(4-6-11)16-17(22-2)15(20)14-12(19)7-10(18)8-13(14)23-16/h3-8,18-19H,1-2H3
InChIKey RJCJVIFSIXKSAH-UHFFFAOYSA-N
Formula C17H14O6
HBA 6
HBD 2
MW 314.29
Rotatable Bonds 3
TPSA 89.13
LogP 2.89
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 314.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Artemisia campestris Asteraceae Plantae 72337
2 Senecio roseiflorus Asteraceae Plantae 1886451
3 Gardenia ternifolia Rubiaceae Plantae 1237590

Showing of synonyms

  • Awas E, Omosa LK, et al. (2016). Antioxidant activities of flavonoid aglycones from Kenyan Gardenia ternifolia Schum and Thonn. IOSR Journal of Pharmacy and Biological Sciences,2016,11(3),136-141. [View] [PubMed]
  • Kerubo LO, Midiwo JO, et al. (2013). Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus. Natural Product Communications,2013,8(2),175-176. [View] [PubMed]
  • Ferchichi L, Merza J, et al. (2006). Occurrence of isocoumarinic and phenolic derivatives in Artemisia campestris L. subsp. campestris.. Biochemical Systematics and Ecology,2006,34,829-832. [View]
CPRiL: 297913
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 314.29 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 314.29 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 314.29 g/mol

Anti-plasmodial
Antioxidant

Absorption

Caco-2 (logPapp)
-4.65
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.790
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.74

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.300
Plasma Protein Binding
83.11
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.190
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.660
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.340
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.890
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.290
Rat (Acute)
2.180
Rat (Chronic Oral)
2.550
Fathead Minnow
4.820
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
451.910
Hydration Free Energy
-11.050
Log(D) at pH=7.4
2.980
Log(P)
3.5
Log S
-5.21
Log(Vapor Pressure)
-7.74
Melting Point
209.95
pKa Acid
7.87
pKa Basic
3.74
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9757
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9757
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9750
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9750
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9625
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9625
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9545
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9545
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9514
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9514
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9439
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9439
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9369
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.9369
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9365
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9365
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9235
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9235
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9228
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9228
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9225
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9225
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9219
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9219
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9194
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9194
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9158
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9158
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9131
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9131
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9112
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9112
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9109
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9109
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9100
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9100
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9072
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9072
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9066
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9066
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.9061
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.9061
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9054
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9054
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9026
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9026
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8976
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8976
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8970
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8970
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8969
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8969
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8965
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8965
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8960
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8960
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8956
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8956
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8948
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8948
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8946
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8946
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8924
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8924
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8913
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8913
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8869
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8869
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8818
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8818
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8788
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8788
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8745
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8745
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8732
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8732
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8675
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8675
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8672
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8672
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8669
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8669
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8662
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8662
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8661
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8661
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8638
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8638
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8631
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8631
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8609
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8609
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8568
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8568
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8538
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8538
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8508
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8508
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8486
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8486
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8484
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8484
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8480
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8480
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8476
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8476
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8467
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8467
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8436
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8436
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8399
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8399
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8394
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8394
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8365
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8365
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8364
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8364
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8315
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8315
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8299
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8299
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8278
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8278
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8277
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8277
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8272
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8272
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8262
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8262
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8260
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8260
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8254
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8254
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8250
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8250
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8233
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8233
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8228
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8228
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8221
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8221
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8210
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8210
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8209
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8209
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8183
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8183
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8182
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8182
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8172
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8172
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8171
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8171
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8170
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8170
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8146
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8146
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8139
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8139
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8134
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8134
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8115
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8115
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8099
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8099
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8096
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8096
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8048
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8048
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8039
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8039
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8018
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8018
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8010
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8010
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7973
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7973
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7964
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7964
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7947
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7947
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7942
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7942
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7941
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7941
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7926
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7926
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7914
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7914
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7903
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7903
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7882
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7882
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7882
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7882
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7866
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7866
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7863
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7863
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7851
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7851
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7850
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7850
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7846
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7846
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7841
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7841
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7833
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7833
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7827
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7827
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7825
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7825
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7824
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7824
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7814
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7814
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7804
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7804
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7802
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7802
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7800
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7800
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7782
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7782
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7776
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7776
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7773
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7773
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7755
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7755
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7754
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7754
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7726
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7726
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7715
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7715
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7706
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7706
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7699
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7699
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7698
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7698
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7696
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7696
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7695
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7695
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7691
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7691
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7687
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7687
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7686
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7686
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7665
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7665
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7656
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7656
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7647
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7647
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7636
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7636
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7634
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7634
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7614
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7614
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7608
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7608
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7603
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7603
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7598
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7598
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7597
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7597
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7595
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7595
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7588
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7588
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7582
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7582
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7575
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7575
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7562
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7562
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7553
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7553
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7498
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7498
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7493
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7493
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7488
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7488
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7488
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7488
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7482
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7482
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7475
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7475
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7470
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7470
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7453
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7453
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7433
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7433
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7427
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7427
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7419
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7419
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7408
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7408
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7402
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7402
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7390
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7390
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7390
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7390
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7386
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7386
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7384
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7384
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7381
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7381
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7380
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7380
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7380
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7380
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7369
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7369
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7364
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7364
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7362
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7362
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7360
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7360
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7357
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7357
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7354
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7354
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7347
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7347
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7341
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7341
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7332
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7332
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7319
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7319
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7316
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7316
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7309
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7309
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7306
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7306
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7293
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7293
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7285
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7285
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7283
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7283
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7282
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7282
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7282
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7282
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7270
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7270
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7269
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7269
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7268
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7268
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7267
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7267
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7267
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7267
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7265
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7265
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7258
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7258
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7256
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7256
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7249
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7249
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7249
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7249
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7239
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7239
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7238
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7238
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7237
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7237
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7232
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7232
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7226
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7226
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7224
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7224
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7224
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7224
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7215
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7215
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7215
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7215
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7212
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7212
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7211
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7211
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7203
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7203
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7200
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7200
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7198
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7198
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7194
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7194
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7191
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7191
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7189
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7189
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7175
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7175
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7173
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7173
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7172
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7172
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7163
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7163
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7159
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7159
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7156
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7156
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7152
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7152
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7149
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7149
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7146
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7146
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7144
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7144
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7143
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7143
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7142
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7142
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7136
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7136
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7133
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7133
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7127
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7127
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7124
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7124
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7124
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7124
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7114
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7114
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7113
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7113
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7113
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7113
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7112
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7112
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7111
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7111
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7110
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7110
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7109
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7109
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7107
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7107
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7107
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7107
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7101
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7101
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7099
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7099
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7082
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7082
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7082
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7082
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7075
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7075
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7068
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7068
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7066
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7066
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 4 0.7059
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 4 0.7059
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7051
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7051
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7050
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7050
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7048
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7048
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7046
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7046
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7044
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7044
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7042
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7042
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7042
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7042
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7040
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7040
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7036
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7036
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7032
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7032
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7028
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7028
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7027
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7027
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7025
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7025
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7019
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7019
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 5 0.7014
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 5 0.7014
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7010
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7010
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7010
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7010
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7009
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7009
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7009
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7009
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7007
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7007
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7006
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7006
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7003
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7003

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