Apigenin 7-glucuronide - Compound Card

Apigenin 7-glucuronide

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Apigenin 7-glucuronide

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone Glycoside
Canonical Smiles OC(=O)C1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)c2ccc(cc2)O)C([C@H]([C@@H]1O)O)O
InChI InChI=1S/C21H18O11/c22-9-3-1-8(2-4-9)13-7-12(24)15-11(23)5-10(6-14(15)31-13)30-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21-23,25-27H,(H,28,29)/t16-,17-,18?,19?,21+/m0/s1
InChIKey JBFOLLJCGUCDQP-ZAJNMQHRSA-N
Formula C21H18O11
HBA 10
HBD 6
MW 446.36
Rotatable Bonds 4
TPSA 187.12
LogP 0.14
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 32
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 446.08
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Artemisia judaica Asteraceae Plantae 205369
2 Sonchus oleraceus Asteraceae Plantae 50207
3 Sonchus tenerrimus Asteraceae Plantae 255578
4 Sonchus bourgeaui Asteraceae Plantae 50194
5 Sonchus asper Asteraceae Plantae 50193
6 Sonchus macrocarpus Asteraceae Plantae 2984305
7 Sonchus hydrophilus Asteraceae Plantae 255580
8 Sonchus maritimus Asteraceae Plantae 50206
9 Sonchus crassifolius Asteraceae Plantae 381731
10 Sonchus arvensis Asteraceae Plantae 50192
11 Sonchus brachyotus Asteraceae Plantae 381730
12 Sonchus congestus Asteraceae Plantae 50197
13 Sonchus acaulis Asteraceae Plantae 50191
14 Sonchus hierrensis Asteraceae Plantae 50203
15 Sonchus gomerensis Asteraceae Plantae 1519691
16 Sonchus ustulatus Asteraceae Plantae 50215
17 Sonchus fauces-orci Asteraceae Plantae 50199
18 Sonchus pinnatifidus Asteraceae Plantae 50211
19 Sonchus brachylobus Asteraceae Plantae 50195
20 Sonchus pinnatus Asteraceae Plantae 50212
21 Sonchus palmensis Asteraceae Plantae 50209
22 Sonchus fruticosus Asteraceae Plantae 50200
23 Sonchus lidii Asteraceae Plantae 50190
24 Sonchus gandogeri Asteraceae Plantae 50201
25 Sonchus schweinfurthii Asteraceae Plantae 50213
26 Sonchus bipontini Asteraceae Plantae 381729
27 Sonchus luxurians Asteraceae Plantae 50205
28 Sonchus melanolepis Asteraceae Plantae 212303
29 Sonchus nanus Asteraceae Plantae 50190
30 Taeckholmia capillaris Asteraceae Plantae 50221
31 Taeckholmia canariensis Asteraceae Plantae 50196
32 Taeckholmia microcarpa Asteraceae Plantae 329331
33 Taeckholmia heterophylla Asteraceae Plantae 50222

Showing of synonyms

  • Mansour RMA, Saleh NAM, et al. (1983). A chemosystematic study of the phenolics of Sonchus.. Phytochemistry,1983,22(2),489-492. [View]
  • Saleh NAM, El-Negoumy SI, et al. (1987). Flavonoids of Artemisia judaica, A. monosperma and A. Herba-alba.. Phytochemistry,1987,26(11),3059-3064. [View]
Pubchem: 44257800
Nmrshiftdb2: 60073375
CPRiL: 412932
Structure

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC4CCCCO4

Level: 2

Mol. Weight: 446.36 g/mol

Structure

SMILES: O=c1ccoc(c12)cc(cc2)OC3CCCCO3

Level: 1

Mol. Weight: 446.36 g/mol

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 446.36 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 446.36 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 446.36 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 446.36 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-6.89
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Non-Absorbed
Madin-Darby Canine Kidney
-5.33
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
0.07

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.15
Plasma Protein Binding
83.29
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.95
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
-1.43
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.02
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.02
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-69.82
Rat (Acute)
2.2
Rat (Chronic Oral)
4.1
Fathead Minnow
4.34
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
590.76
Hydration Free Energy
-4.61
Log(D) at pH=7.4
-0.64
Log(P)
0.94
Log S
-4.16
Log(Vapor Pressure)
-12.51
Melting Point
224.49
pKa Acid
4.93
pKa Basic
5.85
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9543
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9543
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9489
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9489
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9255
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9255
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9188
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9188
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9083
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9083
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.9019
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.9019
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8995
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8995
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8768
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8768
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8717
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8717
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8686
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8686
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8667
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8667
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8645
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8645
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8629
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8629
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8545
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8545
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8537
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8537
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8415
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8415
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8408
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8408
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8401
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8401
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8334
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8334
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8305
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8305
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8292
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8292
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8268
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8268
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8267
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8267
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8238
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8238
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8176
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8176
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8154
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8154
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8088
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8088
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8005
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8005
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7980
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7980
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7919
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7919
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7918
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7918
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7910
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7910
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7906
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7906
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7866
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7866
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7864
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7864
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7859
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7859
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7846
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7846
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7837
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7837
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7771
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7771
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7762
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7762
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7729
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7729
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7717
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7717
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7711
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7711
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7676
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7676
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 3 0.7643
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 3 0.7643
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7617
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7617
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7613
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7613
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7558
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7558
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7545
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7545
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7540
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7540
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7539
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7539
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7537
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7537
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7535
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7535
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7518
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7518
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7518
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7518
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7502
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7502
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7500
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7500
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.7497
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.7497
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7478
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7478
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7461
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7461
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7454
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7454
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7443
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7443
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7409
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7409
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7393
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7393
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7391
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7391
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7386
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7386
2-dehydro-3-deoxyphosphooctonate aldolase P0A715 KDSA_ECOLI Escherichia coli 3 0.7355
2-dehydro-3-deoxyphosphooctonate aldolase P0A715 KDSA_ECOLI Escherichia coli 3 0.7355
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7352
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7352
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7309
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7309
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7299
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7299
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7288
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7288
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7277
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7277
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7274
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7274
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7274
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7274
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7271
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7271
Sensor protein PhoQ P23837 PHOQ_ECOLI Escherichia coli 3 0.7221
Sensor protein PhoQ P23837 PHOQ_ECOLI Escherichia coli 3 0.7221
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7204
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.7204
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.7204
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7204
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7198
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7198
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7193
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7193
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7180
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7180
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7175
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7175
Chemotaxis protein CheA Q56310 CHEA_THEMA Thermotoga maritima 3 0.7165
Chemotaxis protein CheA Q56310 CHEA_THEMA Thermotoga maritima 3 0.7165
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7162
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7162
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7152
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7152
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7151
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7151
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7140
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7140
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7118
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7118
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7116
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7116
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7114
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7114
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7104
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7104
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7104
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7104
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7098
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7098
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7085
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7085
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7079
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7079
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7074
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7074
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7060
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7060
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7046
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7046
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7041
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7041
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7029
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7029
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7022
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7022
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7020
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7020
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7017
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7017
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7003
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7003
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7002
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7002

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