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Costic acid methyl ester
- Family: Asteraceae-Compositae
- Kingdom: Plantae
-
Class: Terpenoid
- Subclass: Sesquiterpene
| Canonical Smiles | COC(=O)C(=C)[C@@H]1CC[C@@]2([C@@H](C1)C(=C)CCC2)C |
|---|---|
| InChI | InChI=1S/C16H24O2/c1-11-6-5-8-16(3)9-7-13(10-14(11)16)12(2)15(17)18-4/h13-14H,1-2,5-10H2,3-4H3/t13-,14+,16-/m1/s1 |
| InChIKey | WQPKMCCPWWJBMZ-IJEWVQPXSA-N |
| Formula | C16H24O2 |
| HBA | 2 |
| HBD | 0 |
| MW | 248.37 |
| Rotatable Bonds | 2 |
| TPSA | 26.3 |
| LogP | 3.88 |
| Number Rings | 2 |
| Number Aromatic Rings | 0 |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Fraction CSP3 | 0.69 |
| Exact Mass | 248.18 |
| Number of Lipinski Rule Violations | 0 |
| # | Species | Family | Kingdom | NCBI Taxonomy ID |
|---|---|---|---|---|
| 1 | Artemisia arborescens | Asteraceae-Compositae | Plantae | 72386 |
Showing of synonyms
Costic acid methyl ester
Methyl-.gamma.-costate
WQPKMCCPWWJBMZ-IJEWVQPXSA-N
- Marco JA, Sanz-Cervera JF, et al. (1997). Sesquiterpene lactones and lignans from Artemisia arborescens.. Phytochemistry,1997,44(6),1133-1137. [View]
No compound-protein relationship available.
SMILES: C=C1CCCC(C12)CCCC2
Level: 0
Mol. Weight: 150.26 g/mol
No bioactivities available.
Absorption
- Caco-2 (logPapp)
- -4.62
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -4.270
- Human Oral Bioavailability 50%
- Bioavailable
- P-Glycoprotein Inhibitor
- Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- -2.86
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 0.690
- Plasma Protein Binding
- 59.28
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Substrate
- CYP 3A4 Inhibitor
- Inhibitor
- CYP 3A4 Substrate
- Non-Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 9.850
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Toxic
- Bioconcentration Factor
- 1.160
- Biodegradation
- Safe
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Safe
- Eye Corrosion
- Safe
- Eye Irritation
- Toxic
- Maximum Tolerated Dose
- -0.660
- Liver Injury II
- Toxic
- hERG Blockers
- Safe
- Daphnia Maga
- 4.970
- Micronucleos
- Safe
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- 1.390
- Rat (Acute)
- 2.260
- Rat (Chronic Oral)
- 1.910
- Fathead Minnow
- 3.940
- Respiratory Disease
- Safe
- Skin Sensitisation
- Toxic
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 303.790
- Hydration Free Energy
- -1.420
- Log(D) at pH=7.4
- 4.120
- Log(P)
- 4.72
- Log S
- -5.12
- Log(Vapor Pressure)
- -3.28
- Melting Point
- 51.1
- pKa Acid
- 11.62
- pKa Basic
- 6.35
| Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9493 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9493 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9309 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9309 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9302 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9302 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.9266 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.9266 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 3 | 0.9252 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 3 | 0.9252 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9245 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9245 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9208 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9208 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9207 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9207 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9201 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9201 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.9153 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.9153 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8767 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8767 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8747 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8747 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8584 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8584 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8453 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8453 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.8384 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.8384 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8373 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8373 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.8286 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.8286 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.8286 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.8286 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7998 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7998 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.7978 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.7978 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7948 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7948 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7935 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7935 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7924 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7924 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7879 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7879 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7815 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7815 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7807 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7807 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7800 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7800 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7798 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7798 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7779 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7779 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7774 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7774 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7771 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7771 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7766 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7766 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7763 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7763 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7742 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7742 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7737 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7737 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 2 | 0.7735 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 2 | 0.7735 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7734 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7734 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7722 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7722 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7717 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7717 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7716 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7716 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7708 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7708 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7705 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7705 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7702 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7702 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7700 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7700 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.7696 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.7696 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7695 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7695 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7690 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7690 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7685 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7685 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 3 | 0.7681 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7681 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 3 | 0.7681 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7681 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7679 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7679 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 2 | 0.7676 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 2 | 0.7676 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7676 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7676 |
| Androgen receptor | P19091 | ANDR_MOUSE | Mus musculus | 3 | 0.7675 |
| Androgen receptor | P19091 | ANDR_MOUSE | Mus musculus | 3 | 0.7675 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7671 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7671 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7666 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7666 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7660 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7660 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7657 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7657 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7654 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7654 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7651 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7651 |
| Ferrochelatase, mitochondrial | P22830 | HEMH_HUMAN | Homo sapiens | 2 | 0.7643 |
| Ferrochelatase, mitochondrial | P22830 | HEMH_HUMAN | Homo sapiens | 2 | 0.7643 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7636 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7636 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7630 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7630 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7626 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7626 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7622 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7622 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7620 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7620 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7614 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7614 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7612 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7612 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7612 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7612 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7585 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7585 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 2 | 0.7557 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 2 | 0.7557 |
| Fatty acid-binding protein, liver | P80226 | FABPL_CHICK | Gallus gallus | 2 | 0.7548 |
| Fatty acid-binding protein, liver | P80226 | FABPL_CHICK | Gallus gallus | 2 | 0.7548 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 2 | 0.7544 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 2 | 0.7544 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 3 | 0.7535 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 3 | 0.7535 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7507 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7507 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 2 | 0.7501 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 2 | 0.7501 |
| Prostaglandin reductase 2 | Q8N8N7 | PTGR2_HUMAN | Homo sapiens | 2 | 0.7474 |
| Prostaglandin reductase 2 | Q8N8N7 | PTGR2_HUMAN | Homo sapiens | 2 | 0.7474 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7470 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7470 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7418 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7418 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7418 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7418 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7411 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7411 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7393 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7393 |
| Nuclear receptor ROR-gamma | P51449 | RORG_HUMAN | Homo sapiens | 2 | 0.7374 |
| Nuclear receptor ROR-gamma | P51449 | RORG_HUMAN | Homo sapiens | 2 | 0.7374 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 2 | 0.7359 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 2 | 0.7359 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 2 | 0.7321 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 2 | 0.7321 |
| Avidin | P02701 | AVID_CHICK | Gallus gallus | 3 | 0.7308 |
| Avidin | P02701 | AVID_CHICK | Gallus gallus | 3 | 0.7308 |
| Nuclear receptor subfamily 1 group I member 3 | O35627 | NR1I3_MOUSE | Mus musculus | 2 | 0.7296 |
| Nuclear receptor subfamily 1 group I member 3 | O35627 | NR1I3_MOUSE | Mus musculus | 2 | 0.7296 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7287 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7287 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 2 | 0.7280 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 2 | 0.7280 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 2 | 0.7233 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 2 | 0.7233 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7216 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7216 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7190 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7190 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7184 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7184 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7184 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7184 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7166 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7166 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.7072 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.7072 |
| Nuclear receptor coactivator 2 | Q15596 | NCOA2_HUMAN | Homo sapiens | 3 | 0.7036 |
| Soluble cytochrome b562 | P0ABE7 | C562_ECOLX | Escherichia coli | 2 | 0.7036 |
| Soluble cytochrome b562 | P0ABE7 | C562_ECOLX | Escherichia coli | 2 | 0.7036 |
| Nuclear receptor coactivator 2 | Q15596 | NCOA2_HUMAN | Homo sapiens | 3 | 0.7036 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7011 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7011 |