12-N-methyl stevensine - Compound Card

12-N-methyl stevensine

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12-N-methyl stevensine

Structure
Zoomed Structure
  • Family: Dictyonellidae
  • Kingdom: Animalia
  • Class: Alkaloid
Canonical Smiles O=C1NCC=C(c2c1[nH]c(c2Br)Br)c1c[nH]c(=[NH2+])n1C
InChI InChI=1S/C12H11Br2N5O/c1-19-6(4-17-12(19)15)5-2-3-16-11(20)9-7(5)8(13)10(14)18-9/h2,4,18H,3H2,1H3,(H2,15,17)(H,16,20)/p+1
InChIKey OFVTZRHCBUKTFP-UHFFFAOYSA-O
Formula C12H12Br2N5O+
HBA 2
HBD 4
MW 402.07
Rotatable Bonds 1
TPSA 91.2
LogP 0.04
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 1
Fraction CSP3 0.17
Exact Mass 399.94
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Stylissa species Dictyonellidae Animalia 237127

Showing of synonyms

  • Fouad MA, Debbab A, et al. (2012). New bioactive alkaloids from the marine sponge Stylissa sp.. Tetrahedron,2012,68,10176-10179. [View]
Pubchem: 71496869

No compound-protein relationship available.

Structure

SMILES: c1c[nH]c(c12)C(=O)NCC=C2c3c[nH]c(=[NH2+])[nH]3

Level: 1

Mol. Weight: 230.25 g/mol

Structure

SMILES: c1c[nH]c(c12)C(=O)NCC=C2

Level: 0

Mol. Weight: 148.16 g/mol

Structure

SMILES: [NH2+]=c1[nH]cc[nH]1

Level: 0

Mol. Weight: 84.1 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-5.56
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.31
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
3.13

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.86
Plasma Protein Binding
43.21
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.67
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-1.82
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.05
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.14
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-5.33
Rat (Acute)
2.86
Rat (Chronic Oral)
2.09
Fathead Minnow
6.74
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
563.75
Hydration Free Energy
-6.16
Log(D) at pH=7.4
1.61
Log(P)
-0.01
Log S
-2.55
Log(Vapor Pressure)
-10.39
Melting Point
329.18
pKa Acid
7.82
pKa Basic
2.94
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.9577
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.9577
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.9504
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.9504
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9169
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9169
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.9148
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.9148
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9132
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9132
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9118
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9118
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.9112
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.9112
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.9090
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.9090
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9060
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9060
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9051
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9051
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.9015
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.9015
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.9008
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.9008
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8998
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8998
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 3 0.8812
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 3 0.8812
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.8720
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.8720
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8677
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8677
Glucanase Q7LHI2 Q7LHI2_PHACH Phanerodontia chrysosporium 3 0.8665
Glucanase Q7LHI2 Q7LHI2_PHACH Phanerodontia chrysosporium 3 0.8665
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8662
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8662
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8642
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8642
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8631
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8631
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8578
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8578
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8508
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8508
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8466
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8466
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8332
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8332
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8317
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8317
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7934
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7934
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7916
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7916
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.7868
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.7868
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7844
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7844
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7825
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7825
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7763
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7763
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7750
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7750
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7738
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7738
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7730
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7730
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7713
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7713
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7680
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7680
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7679
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7679
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7676
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7676
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7652
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7652
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7633
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7633
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7575
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7575
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7569
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7569
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7550
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7550
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7540
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7540
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7509
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7509
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7508
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7508
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7494
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7494
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7491
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7491
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7489
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7489
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7485
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7485
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7481
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7481
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7451
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7451
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7440
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7440
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7438
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7438
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 3 0.7387
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 3 0.7387
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7367
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7367
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7367
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7367
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7355
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7355
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7350
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7350
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7344
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7344
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7342
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7342
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7341
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7341
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7332
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7332
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7325
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7325
Nuclear receptor subfamily 5 group A member 2 O00482 NR5A2_HUMAN Homo sapiens 3 0.7322
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7322
Nuclear receptor subfamily 5 group A member 2 O00482 NR5A2_HUMAN Homo sapiens 3 0.7322
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7322
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7321
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7321
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7316
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7316
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7315
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7315
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7295
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7295
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7287
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7287
Lactoperoxidase A5JUY8 PERL_BUBBU Bubalus bubalis 3 0.7276
Lactoperoxidase A5JUY8 PERL_BUBBU Bubalus bubalis 3 0.7276
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7271
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7271
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7269
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7269
3-oxoacyl-[acyl-carrier-protein] synthase 1 Q2YQQ9 Q2YQQ9_BRUA2 Brucella abortus 3 0.7264
3-oxoacyl-[acyl-carrier-protein] synthase 1 Q2YQQ9 Q2YQQ9_BRUA2 Brucella abortus 3 0.7264
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 3 0.7255
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 3 0.7255
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7249
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7249
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7249
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7249
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 3 0.7249
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 3 0.7249
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7241
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7241
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7238
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7238
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7236
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7236
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7230
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7230
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 3 0.7228
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 3 0.7228
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7225
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7225
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7224
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7224
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7220
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7220
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7209
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7209
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7196
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7196
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7182
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7182
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7177
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7177
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7175
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7175
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7168
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7168
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 2 0.7152
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 2 0.7152
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7152
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7152
Purine nucleoside phosphorylase P50389 PNPH_SACS2 Saccharolobus solfataricus 3 0.7147
Purine nucleoside phosphorylase P50389 PNPH_SACS2 Saccharolobus solfataricus 3 0.7147
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7145
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7145
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7142
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7142
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7142
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7142
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7141
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7141
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7137
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7137
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7135
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7135
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7134
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7134
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7131
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7131
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7127
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7127
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7127
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7127
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7121
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7121
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7119
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7119
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7119
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7119
Nitrate reductase [NADH] 1 P17571 NIA1_MAIZE Zea mays 2 0.7114
Nitrate reductase [NADH] 1 P17571 NIA1_MAIZE Zea mays 2 0.7114
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7113
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7113
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7113
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7113
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7112
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7112
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7111
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7111
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7108
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7108
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7107
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7107
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7100
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7100
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7100
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7100
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7100
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7100
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7097
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7097
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7093
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7093
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7091
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7091
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7083
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7083
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7081
Pyridine nucleotide-disulfide oxidoreductase, class I A0A6L7H7X4 A0A0F7RMY2_BACAN Bacillus anthracis 2 0.7081
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7081
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7081
Pyridine nucleotide-disulfide oxidoreductase, class I A0A6L7H7X4 A0A0F7RMY2_BACAN Bacillus anthracis 2 0.7081
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7081
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7078
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7078
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7073
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7073
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7069
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7069
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7062
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7062
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7056
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7056
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7056
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7056
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7053
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7053
DNA (cytosine-5)-methyltransferase 1 P13864 DNMT1_MOUSE Mus musculus 2 0.7051
DNA (cytosine-5)-methyltransferase 1 P13864 DNMT1_MOUSE Mus musculus 2 0.7051
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7044
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7044
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7042
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7042
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7041
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7041
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7034
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7034
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7031
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7031
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7029
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7029
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7017
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7017
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7016
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7016
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7008
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7008
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7002
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7002

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