12-N-methyl-2-debromostevensine - Compound Card

12-N-methyl-2-debromostevensine

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12-N-methyl-2-debromostevensine

Structure
Zoomed Structure
  • Family: Dictyonellidae
  • Kingdom: Animalia
  • Class: Alkaloid
Canonical Smiles Brc1c[nH]c2c1C(=CCNC2=O)c1c[nH]c(=[NH2+])n1C
InChI InChI=1S/C12H12BrN5O/c1-18-8(5-17-12(18)14)6-2-3-15-11(19)10-9(6)7(13)4-16-10/h2,4-5,16H,3H2,1H3,(H2,14,17)(H,15,19)/p+1
InChIKey OLFXKPISVRKHPL-UHFFFAOYSA-O
Formula C12H13BrN5O+
HBA 2
HBD 4
MW 323.17
Rotatable Bonds 1
TPSA 91.2
LogP -0.72
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 19
Formal Charge 1
Fraction CSP3 0.17
Exact Mass 322.03
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Stylissa species Dictyonellidae Animalia 237127

Showing of synonyms

  • Fouad MA, Debbab A, et al. (2012). New bioactive alkaloids from the marine sponge Stylissa sp.. Tetrahedron,2012,68,10176-10179. [View]
Pubchem: 71496870

No compound-protein relationship available.

Structure

SMILES: c1c[nH]c(c12)C(=O)NCC=C2c3c[nH]c(=[NH2+])[nH]3

Level: 1

Mol. Weight: 230.25 g/mol

Structure

SMILES: c1c[nH]c(c12)C(=O)NCC=C2

Level: 0

Mol. Weight: 148.16 g/mol

Structure

SMILES: [NH2+]=c1[nH]cc[nH]1

Level: 0

Mol. Weight: 84.1 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.6
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.37
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
3.27

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.81
Plasma Protein Binding
42.12
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.86
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
-2.03
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.07
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.06
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-6.49
Rat (Acute)
2.76
Rat (Chronic Oral)
2.24
Fathead Minnow
6.66
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
545.01
Hydration Free Energy
-6.02
Log(D) at pH=7.4
0.62
Log(P)
-0.38
Log S
-2.17
Log(Vapor Pressure)
-10.34
Melting Point
306.45
pKa Acid
9.0
pKa Basic
3.35
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9102
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9102
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.9076
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.9076
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9065
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9065
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.9044
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.9044
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9028
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9028
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.9012
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.9012
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8991
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8991
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8965
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8965
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8954
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8954
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8793
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8793
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8776
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8776
Glucanase Q7LHI2 Q7LHI2_PHACH Phanerodontia chrysosporium 3 0.8636
Glucanase Q7LHI2 Q7LHI2_PHACH Phanerodontia chrysosporium 3 0.8636
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8624
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8624
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 3 0.8589
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 3 0.8589
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8574
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8574
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8548
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8548
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.8545
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.8545
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8451
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8451
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8448
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8448
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8298
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8298
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8290
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8290
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8238
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8238
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8205
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8205
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.8095
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.8095
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7889
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7889
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7867
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7867
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7839
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7839
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7758
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7758
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7739
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7739
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7656
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7656
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7649
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.7649
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.7649
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7649
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7646
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7646
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7628
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7628
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7626
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7626
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7599
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7599
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7582
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7582
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7564
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7564
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7562
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7562
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7543
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7543
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7533
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7533
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7514
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7514
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7509
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7509
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7507
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7507
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7506
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7506
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7491
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7491
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.7490
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.7490
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7453
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7453
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7421
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7421
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7394
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7394
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7393
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7393
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7373
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7373
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7350
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7350
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7337
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7337
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7322
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7322
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7322
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7322
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7318
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7318
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7301
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7301
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7298
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7298
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7297
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7297
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7291
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7291
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7270
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7270
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 3 0.7249
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 3 0.7249
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 3 0.7243
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 3 0.7243
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7242
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7242
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7235
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7235
3-oxoacyl-[acyl-carrier-protein] synthase 1 Q2YQQ9 Q2YQQ9_BRUA2 Brucella abortus 3 0.7214
3-oxoacyl-[acyl-carrier-protein] synthase 1 Q2YQQ9 Q2YQQ9_BRUA2 Brucella abortus 3 0.7214
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7209
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7209
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7207
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7207
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7206
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7206
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 2 0.7200
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 2 0.7200
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7199
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7199
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 3 0.7197
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 3 0.7197
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7195
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7195
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7191
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7191
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7190
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7190
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7183
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7183
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7182
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7182
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7182
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7182
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7180
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7180
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7170
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7170
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7166
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7166
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7140
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7140
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 3 0.7139
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 3 0.7139
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7129
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7129
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7126
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7126
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7120
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7120
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7118
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7118
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7112
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7112
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7103
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7103
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7098
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7098
Lactoperoxidase A5JUY8 PERL_BUBBU Bubalus bubalis 3 0.7097
Lactoperoxidase A5JUY8 PERL_BUBBU Bubalus bubalis 3 0.7097
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7095
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7095
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7089
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7089
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7084
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7084
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7082
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7082
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7079
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7079
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7079
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7079
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7079
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7079
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7078
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7078
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7078
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7078
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7077
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7077
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7071
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7071
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7042
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7042
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7040
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7040
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7038
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7038
Arginine kinase O15992 KARG_ANTJA Anthopleura japonica 2 0.7036
Arginine kinase O15992 KARG_ANTJA Anthopleura japonica 2 0.7036
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7034
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7034
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7031
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7031
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7029
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7029
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7020
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7020
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7008
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7008
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7005
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7005

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