Austramide - Compound Card

Austramide

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Austramide

Structure
Zoomed Structure
  • Family: Eurotiomycetidae
  • Kingdom: Fungi
  • Class: Amide
Canonical Smiles NC(=O)c1c(C)cc(cc1O)Oc1ccc(c(c1)C)O
InChI InChI=1S/C15H15NO4/c1-8-5-10(3-4-12(8)17)20-11-6-9(2)14(15(16)19)13(18)7-11/h3-7,17-18H,1-2H3,(H2,16,19)
InChIKey RRLREWMAQPONDJ-UHFFFAOYSA-N
Formula C15H15NO4
HBA 4
HBD 3
MW 273.29
Rotatable Bonds 3
TPSA 92.78
LogP 2.61
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 273.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Aspergillus austroafricanus Eurotiomycetidae Fungi 1220192

Showing of synonyms

  • Ebrahim W, El-Neketi M, et al. (2016). Metabolites from the fungal endophyte Aspergillus austroafricanus in axenic culture and in fungal−bacterial mixed cultures. Journal of Natural Products,2016,79,914-922. [View] [PubMed]
Pubchem: 162817199
Nmrshiftdb2: 70000352

No compound-protein relationship available.

Structure

SMILES: c1ccccc1Oc2ccccc2

Level: 1

Mol. Weight: 170.21 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.64
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.880
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.78

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.220
Plasma Protein Binding
70.05
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.490
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.830
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.680
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.350
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.540
Rat (Acute)
1.970
Rat (Chronic Oral)
2.200
Fathead Minnow
4.130
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
407.420
Hydration Free Energy
-13.400
Log(D) at pH=7.4
2.590
Log(P)
2.9
Log S
-3.77
Log(Vapor Pressure)
-7.65
Melting Point
194.01
pKa Acid
8.5
pKa Basic
5.12
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.9406
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.9406
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9341
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9341
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9279
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9279
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9216
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9216
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.9139
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.9139
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.9106
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.9106
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9096
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9096
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8980
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8980
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8957
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8957
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.8934
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.8934
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8933
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8933
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8927
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8927
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8878
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8878
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 3 0.8846
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 3 0.8846
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8753
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8753
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8745
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8745
Ficolin-2 Q15485 FCN2_HUMAN Homo sapiens 3 0.8730
Ficolin-2 Q15485 FCN2_HUMAN Homo sapiens 3 0.8730
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8713
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8713
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.8699
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.8699
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8695
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8695
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8685
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8685
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.8678
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.8678
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8625
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8625
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8618
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8618
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8616
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8616
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8590
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8590
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8568
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8568
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8541
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8541
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 3 0.8517
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 3 0.8517
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8500
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8500
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8434
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8434
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8399
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8399
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8399
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8399
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8327
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8327
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8319
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8319
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8305
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8305
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8300
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8300
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8293
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8293
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8285
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8285
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8276
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8276
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8249
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8249
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8242
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8242
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8229
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8229
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8159
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8159
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8150
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8150
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8144
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8144
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8139
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8139
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8136
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8136
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8108
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8108
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8065
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8065
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8043
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8043
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8042
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8042
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8011
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8011
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8005
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8005
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8000
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8000
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8000
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8000
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7984
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7984
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 3 0.7978
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 3 0.7978
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7966
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7966
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7939
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7939
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7931
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7931
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7925
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7925
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.7922
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.7922
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7918
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7918
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7918
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7918
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7915
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7915
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7900
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7900
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7897
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7897
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7869
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7869
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7839
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7839
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7839
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7839
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7834
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7834
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7805
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7805
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7755
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7755
Ornithine transcarbamylase, mitochondrial P00480 OTC_HUMAN Homo sapiens 3 0.7737
Ornithine transcarbamylase, mitochondrial P00480 OTC_HUMAN Homo sapiens 3 0.7737
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7736
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7736
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7715
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7715
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7714
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7714
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7707
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7707
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7684
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7684
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7681
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7681
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7661
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7661
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 3 0.7654
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 3 0.7654
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7619
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7619
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7619
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7619
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7613
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7613
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7605
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7605
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7596
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7596
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7589
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7589
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7588
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7588
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7586
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7586
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7577
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7577
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7573
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7573
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7558
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7558
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7558
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7558
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7556
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7556
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7538
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7538
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7525
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7525
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7518
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7518
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7509
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7509
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 3 0.7501
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7501
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7501
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 3 0.7501
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7501
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7501
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7495
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7495
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7494
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7494
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7493
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7493
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7489
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7489
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7486
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7486
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7468
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7468
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7466
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7466
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7461
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7461
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7458
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7458
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7456
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7456
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7451
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7451
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7448
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7448
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7439
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7439
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.7431
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7431
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7431
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.7431
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7430
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7430
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7425
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7425
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7411
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7411
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7409
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7409
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7402
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7402
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7398
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7398
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7398
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7398
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7396
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7396
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7394
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7394
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7385
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7385
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7378
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7378
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7374
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7374
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7372
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7372
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7370
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7370
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7360
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7360
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7352
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7352
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 4 0.7345
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 4 0.7345
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 3 0.7340
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 3 0.7340
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7334
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7334
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7334
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7334
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7334
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7334
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7328
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7328
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7327
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7327
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7322
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7322
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7317
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7317
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7317
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7317
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7316
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7316
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7312
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7312
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 3 0.7308
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 3 0.7308
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7302
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7302
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7300
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7300
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7300
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7300
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7299
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7299
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7299
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7299
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7287
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7287
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7285
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7285
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 4 0.7274
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 4 0.7274
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 3 0.7272
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 3 0.7272
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7269
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7269
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.7269
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.7269
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7266
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7266
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7260
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7260
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7258
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7258
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7258
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7258
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7256
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7256
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7245
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7245
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7234
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7234
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7231
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7231
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7230
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7230
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7223
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7223
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7218
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7218
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7216
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7216
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7213
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7213
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7212
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7212
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7210
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7210
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7209
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7209
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7207
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7207
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7206
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7206
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7205
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7205
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.7203
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.7203
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7201
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7201
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7199
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7199
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7197
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7197
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7197
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7197
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7190
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7190
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7188
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7188
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7186
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7186
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7186
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7186
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7184
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7184
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7181
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7181
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7174
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7174
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7173
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7173
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7171
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7171
Heat shock protein 83 P12861 HSP83_TRYBB Trypanosoma brucei brucei 3 0.7163
Heat shock protein 83 P12861 HSP83_TRYBB Trypanosoma brucei brucei 3 0.7163
Myeloperoxidase P05164 PERM_HUMAN Homo sapiens 4 0.7163
Myeloperoxidase P05164 PERM_HUMAN Homo sapiens 4 0.7163
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7161
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7161
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7153
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7153
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7145
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7145
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7145
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7145
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7142
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7142
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7140
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7140
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7140
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7140
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7124
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7124
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7111
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7111
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7110
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7110
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7108
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7108
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7107
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7107
Sterol 14-alpha demethylase Q7Z1V1 CP51_TRYCC Trypanosoma cruzi 3 0.7106
Sterol 14-alpha demethylase Q7Z1V1 CP51_TRYCC Trypanosoma cruzi 3 0.7106
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 3 0.7100
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 3 0.7100
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7097
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7097
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7097
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7097
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7093
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7093
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7084
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7084
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 2 0.7083
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 2 0.7083
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7082
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7082
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7068
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7068
Methionine aminotransferase P77806 YBDL_ECOLI Escherichia coli 3 0.7067
Methionine aminotransferase P77806 YBDL_ECOLI Escherichia coli 3 0.7067
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7065
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7065
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7064
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7064
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7063
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7063
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7062
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7062
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7055
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7055
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7051
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7051
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7050
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7050
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7048
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7048
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7047
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7047
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7039
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7039
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7028
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7028
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7028
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7028
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7026
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7026
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 3 0.7022
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 3 0.7022
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7012
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7012
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7007
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7007
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7002
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7002
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7000
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7000

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