Violaceol II - Compound Card

Violaceol II

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Violaceol II

Structure
Zoomed Structure
  • Family: Fungi - Eurotiomycetidae
  • Kingdom: Fungi
  • Class: Phenolic
    • Subclass: Biphenyl Ether Derivative
Canonical Smiles Cc1cc(O)c(c(c1)O)Oc1cc(C)cc(c1O)O
InChI InChI=1S/C14H14O5/c1-7-4-10(16)14(11(17)5-7)19-12-6-8(2)3-9(15)13(12)18/h3-6,15-18H,1-2H3
InChIKey SXPZFHCIUAADLD-UHFFFAOYSA-N
Formula C14H14O5
HBA 5
HBD 4
MW 262.26
Rotatable Bonds 2
TPSA 90.15
LogP 2.92
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.14
Exact Mass 262.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Aspergillus austroafricanus Eurotiomycetidae Fungi 1220192

Showing of synonyms

  • Ebrahim W, El-Neketi M, et al. (2016). Metabolites from the fungal endophyte Aspergillus austroafricanus in axenic culture and in fungal−bacterial mixed cultures. Journal of Natural Products,2016,79,914-922. [View] [PubMed]
Pubchem: 16196968
Chebi: 64417
Nmrshiftdb2: 70000196
Metabolights: MTBLC64417
Bindingdb: 52756

No compound-protein relationship available.

Structure

SMILES: c1ccccc1Oc2ccccc2

Level: 1

Mol. Weight: 262.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 262.26 g/mol

Antibacterial

Absorption

Caco-2 (logPapp)
-5.34
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.18
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.93

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.0
Plasma Protein Binding
83.97
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.45
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.45
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.37
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.08
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.34
Rat (Acute)
2.26
Rat (Chronic Oral)
3.25
Fathead Minnow
4.05
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
400.49
Hydration Free Energy
-8.77
Log(D) at pH=7.4
2.37
Log(P)
2.72
Log S
-3.08
Log(Vapor Pressure)
-5.64
Melting Point
205.66
pKa Acid
6.78
pKa Basic
7.02
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9434
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9434
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.9297
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.9297
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.9257
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.9257
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8930
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8930
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 4 0.8823
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 4 0.8823
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8810
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8810
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.8802
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.8802
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8779
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8779
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8774
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8774
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8762
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8762
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8760
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8760
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8731
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8731
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 4 0.8585
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 4 0.8585
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.8567
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.8567
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8521
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8521
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.8514
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.8514
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 5 0.8510
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 5 0.8510
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8504
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8504
Enoyl-acyl carrier reductase Q6UCJ9 Q6UCJ9_TOXGO Toxoplasma gondii 4 0.8452
Enoyl-acyl carrier reductase Q6UCJ9 Q6UCJ9_TOXGO Toxoplasma gondii 4 0.8452
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.8412
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.8412
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8323
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8323
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 4 0.8249
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 4 0.8249
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.8248
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.8248
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8223
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8223
Enoyl-acyl carrier reductase C6KSZ2 C6KSZ2_PLAF7 Plasmodium falciparum 4 0.8217
Enoyl-acyl carrier reductase C6KSZ2 C6KSZ2_PLAF7 Plasmodium falciparum 4 0.8217
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8187
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8187
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8180
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8180
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8169
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8169
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8101
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8101
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.8087
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.8087
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7973
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7973
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7963
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7963
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7921
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7921
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 4 0.7899
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 4 0.7899
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.7885
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.7885
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7844
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7844
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7829
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7829
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7817
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7817
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 5 0.7803
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 5 0.7803
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7792
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7792
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7789
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7789
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7772
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7772
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7768
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7768
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7718
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7718
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7685
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7685
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7640
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7640
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7614
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7614
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7607
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7607
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7595
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7595
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7586
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7586
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7582
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7582
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7580
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7580
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7561
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7561
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7547
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7547
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7503
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7503
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7501
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7501
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7467
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7467
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7453
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7453
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7429
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7429
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7425
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7425
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 4 0.7412
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7412
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 4 0.7412
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7412
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7404
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7404
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7403
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7403
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7389
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7389
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 4 0.7370
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 4 0.7370
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7354
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7354
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7349
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7349
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7317
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7317
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7316
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7316
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7315
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7315
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 4 0.7311
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 4 0.7311
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7308
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7308
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 4 0.7305
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 4 0.7305
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7302
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7302
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7293
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7293
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7290
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7290
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7281
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7281
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7281
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7281
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7278
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7278
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7271
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7271
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7269
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7269
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7268
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7268
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7268
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7268
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7257
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7257
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7219
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7219
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7202
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7202
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7196
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7196
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7169
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7169
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7157
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7157
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7151
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7151
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7147
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7147
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7144
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7144
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7144
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7144
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7139
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7139
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7129
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7129
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7124
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7124
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7102
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7102
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7097
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7097
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7061
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7061
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7052
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7052
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7025
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7025
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7025
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7025
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7015
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7015
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7014
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7014
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7005
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7005
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7004
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7004

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