Diorcinol - Compound Card

Diorcinol

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Diorcinol

Structure
Zoomed Structure
  • Family: Fungi - Eurotiomycetidae
  • Kingdom: Fungi
  • Class: Phenolic
    • Subclass: Biphenyl Ether Derivative
Canonical Smiles Cc1cc(Oc2cc(C)cc(c2)O)cc(c1)O
InChI InChI=1S/C14H14O3/c1-9-3-11(15)7-13(5-9)17-14-6-10(2)4-12(16)8-14/h3-8,15-16H,1-2H3
InChIKey SPCJQQBYWVGMQG-UHFFFAOYSA-N
Formula C14H14O3
HBA 3
HBD 2
MW 230.26
Rotatable Bonds 2
TPSA 49.69
LogP 3.51
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 17
Formal Charge 0
Fraction CSP3 0.14
Exact Mass 230.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Aspergillus austroafricanus Eurotiomycetidae Fungi 1220192

Showing of synonyms

  • Ebrahim W, El-Neketi M, et al. (2016). Metabolites from the fungal endophyte Aspergillus austroafricanus in axenic culture and in fungal−bacterial mixed cultures. Journal of Natural Products,2016,79,914-922. [View] [PubMed]
Pubchem: 23396613
Chebi: 64413
Nmrshiftdb2: 60147248
Metabolights: MTBLC64413
CPRiL: 412611
Structure

SMILES: c1ccccc1Oc2ccccc2

Level: 1

Mol. Weight: 230.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 230.26 g/mol

Antibacterial

Absorption

Caco-2 (logPapp)
-4.66
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.42
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.36

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.04
Plasma Protein Binding
67.18
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.58
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.58
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.97
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
4.83
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.31
Rat (Acute)
1.81
Rat (Chronic Oral)
2.24
Fathead Minnow
4.37
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
352.17
Hydration Free Energy
-8.71
Log(D) at pH=7.4
3.17
Log(P)
3.83
Log S
-3.96
Log(Vapor Pressure)
-5.84
Melting Point
173.5
pKa Acid
10.04
pKa Basic
6.6
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9414
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9414
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.9405
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.9405
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9104
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9104
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.9100
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.9100
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9031
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9031
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.9028
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.9028
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.8905
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.8905
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8832
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8832
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.8803
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.8803
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8780
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8780
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8757
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8757
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8750
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8750
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8734
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8734
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8699
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8699
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8664
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8664
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8653
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8653
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8643
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8643
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8638
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8638
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8636
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8636
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8565
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8565
Fatty acid synthase P49327 FAS_HUMAN Homo sapiens 4 0.8560
Fatty acid synthase P49327 FAS_HUMAN Homo sapiens 4 0.8560
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.8506
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.8506
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8489
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8489
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8470
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8470
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8463
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8463
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8429
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8429
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8410
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8410
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8403
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8403
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8386
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8386
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8362
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8362
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.8343
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.8343
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8325
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8325
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8311
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8311
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8275
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8275
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8244
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8244
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8232
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8232
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8219
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8219
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8178
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8178
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8174
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8174
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8164
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8164
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8149
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8149
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8139
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8139
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8130
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8130
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8109
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8109
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8104
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8104
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8101
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8101
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8081
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8081
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8031
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8031
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8024
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8024
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8016
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8016
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.8005
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.8005
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7923
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7923
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7893
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7893
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7869
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7869
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7861
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7861
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7859
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7859
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7855
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7855
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7853
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7853
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7838
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7838
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7838
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7838
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7799
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7799
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7785
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7785
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7768
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7768
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7742
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7742
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7742
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7742
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7741
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7741
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7739
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7739
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7718
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7718
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7710
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7710
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7702
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7702
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7699
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7699
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7699
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7699
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7698
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7698
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7689
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7689
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7689
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7689
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7687
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7687
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7663
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7663
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.7646
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.7646
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7637
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7637
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7624
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7624
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7609
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7609
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7608
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7608
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7603
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7603
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7598
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7598
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7589
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7589
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7579
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7579
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7577
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7577
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7573
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7573
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7556
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7556
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7556
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7556
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7553
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7553
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7551
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7551
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7529
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7529
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7526
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7526
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7523
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7523
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7521
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7521
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7516
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7516
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7500
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7500
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7494
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7494
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7488
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7488
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7485
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7485
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7478
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7478
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7472
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7472
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7469
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7469
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7465
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7465
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7442
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7442
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7437
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7437
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7435
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7435
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7429
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7429
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7429
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7429
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 5 0.7427
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 5 0.7427
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7425
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7425
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7422
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7422
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7417
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7417
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7417
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7417
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7415
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7415
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7407
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7407
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7399
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7399
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7394
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7394
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7388
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7388
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7386
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7386
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7381
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7381
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7375
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7375
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7366
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7366
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7363
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7363
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7358
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7358
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7354
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7354
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7350
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7350
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7346
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7346
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7342
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7342
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7337
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7337
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7336
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7336
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7335
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7335
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7330
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7330
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 4 0.7319
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 4 0.7319
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7319
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7319
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7306
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7306
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7305
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7305
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7298
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7298
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7294
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7294
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7291
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7291
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7288
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7288
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7285
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7285
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7281
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7281
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7281
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7281
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7270
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7270
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7269
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7269
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7268
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7268
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7256
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7256
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7245
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7245
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7242
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7242
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7236
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7236
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7218
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7218
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7216
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7216
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7215
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7215
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7200
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7200
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7200
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7200
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7195
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7195
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.7191
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.7191
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7188
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7188
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7187
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7187
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7184
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7184
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7177
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7177
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7164
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7164
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7164
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7164
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7157
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7157
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7152
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7152
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7148
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7148
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7148
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7148
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7142
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7142
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7141
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7141
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7139
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7139
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7138
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7138
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7127
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7127
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7127
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7127
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7114
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7114
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7114
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7114
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7111
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7111
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7102
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7102
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 4 0.7097
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 4 0.7097
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7086
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7086
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7083
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7083
Transcriptional enhancer factor TEF-4 Q15562 TEAD2_HUMAN Homo sapiens 3 0.7082
Transcriptional enhancer factor TEF-4 Q15562 TEAD2_HUMAN Homo sapiens 3 0.7082
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7070
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7070
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7070
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7070
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7061
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7061
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7058
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7058
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7055
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7055
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7054
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7054
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7051
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7051
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7037
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7037
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7021
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7021
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7020
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7020
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7020
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7020
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7019
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7019
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7014
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7014
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7007
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7007

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