1,5,8-trihydroxy-3,6,7-trimethoxyxanthone - Compound Card

1,5,8-trihydroxy-3,6,7-trimethoxyxanthone

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1,5,8-trihydroxy-3,6,7-trimethoxyxanthone

Structure
Zoomed Structure
  • Family: Gentianaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles COc1cc(O)c2c(c1)oc1c(c2=O)c(O)c(c(c1O)OC)OC
InChI InChI=1S/C16H14O8/c1-21-6-4-7(17)9-8(5-6)24-14-10(11(9)18)12(19)15(22-2)16(23-3)13(14)20/h4-5,17,19-20H,1-3H3
InChIKey QAEDNOBQEIAWSV-UHFFFAOYSA-N
Formula C16H14O8
HBA 8
HBD 3
MW 334.28
Rotatable Bonds 3
TPSA 118.59
LogP 2.09
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 334.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Centaurium spicatum Gentianaceae Plantae 172074

Showing of synonyms

  • El-Shanawany MA, Mohamed GA, et al. (2011). A new xanthone from the roots of Centaurium spicatum. Phytochemistry Letters,2011,4,126-128. [View]
Pubchem: 162991657
Nmrshiftdb2: 70088943

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 196.21 g/mol

Antimicrobial
Antiprotozoal
Cytotoxicity

Absorption

Caco-2 (logPapp)
-5.58
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.150
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.12

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.190
Plasma Protein Binding
62.14
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.180
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.070
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.830
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
7.020
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.910
Rat (Acute)
2.320
Rat (Chronic Oral)
3.340
Fathead Minnow
4.650
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
452.030
Hydration Free Energy
-8.780
Log(D) at pH=7.4
2.730
Log(P)
2.86
Log S
-5.51
Log(Vapor Pressure)
-7.18
Melting Point
202.58
pKa Acid
7.58
pKa Basic
2.92
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9497
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9497
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9414
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9414
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9366
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9366
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9308
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9308
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9288
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9288
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9259
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9259
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9165
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9165
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9111
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9111
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9032
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9032
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8944
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8944
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8923
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8923
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8913
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8913
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8788
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8788
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8761
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8761
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8748
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8748
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8700
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8700
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8684
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8684
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8675
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8675
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8660
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8660
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8530
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8530
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8518
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8518
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8514
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8514
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8509
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8509
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8503
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8503
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8455
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8455
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8389
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8389
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8341
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8341
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8322
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8322
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8257
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8257
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8248
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8248
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8208
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8208
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8200
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8200
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8193
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8193
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8182
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8182
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8130
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8130
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8125
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8125
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8124
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8124
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.8070
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.8070
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7980
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7980
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7976
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7976
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7970
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7970
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7959
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7959
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7943
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7943
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7937
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7937
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7927
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7927
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7874
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7874
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7859
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7859
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7857
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7857
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7846
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7846
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7819
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7819
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7806
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7806
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7763
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7763
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7761
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7761
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7724
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7724
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7711
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7711
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7677
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7677
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7628
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7628
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7597
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7597
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 4 0.7572
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 4 0.7572
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7560
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7560
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7559
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7559
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7554
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7554
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7543
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7543
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7524
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7524
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7517
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7517
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7514
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7514
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7501
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7501
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7473
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7473
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7462
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7462
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7459
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7459
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 4 0.7444
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 4 0.7444
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7420
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7420
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7417
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7417
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7411
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7411
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7408
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7408
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7389
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7389
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7382
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7382
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7382
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7382
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7377
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7377
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7377
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7377
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7363
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7363
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7358
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7358
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7347
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7347
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7331
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7331
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7327
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7327
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7323
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7323
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7318
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7318
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7309
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7309
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7306
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7306
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7302
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7302
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7280
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7280
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7274
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7274
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7270
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7270
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7270
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7270
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7261
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7261
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7253
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7253
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7250
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7250
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7247
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7247
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7247
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7247
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7242
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7242
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7230
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7230
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7213
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7213
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7206
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7206
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7203
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7203
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7198
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7198
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7197
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7197
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7183
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7183
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7178
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7178
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7175
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7175
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7165
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7165
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7156
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7156
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7150
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7150
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7140
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7140
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7114
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7114
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7114
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7114
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7106
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7106
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7106
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7106
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7092
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7092
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7084
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7084
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7084
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7084
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7084
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7084
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 5 0.7080
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 5 0.7080
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7078
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7078
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7054
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7054
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7038
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7038
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7023
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7023
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7021
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7021
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7007
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7007

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