1,8-dihydroxy-3,6-dimethoxyxanthone - Compound Card

1,8-dihydroxy-3,6-dimethoxyxanthone

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1,8-dihydroxy-3,6-dimethoxyxanthone

Structure
Zoomed Structure
  • Family: Plantae - Gentianaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles COc1cc(O)c2c(c1)oc1c(c2=O)c(O)cc(c1)OC
InChI InChI=1S/C15H12O6/c1-19-7-3-9(16)13-11(5-7)21-12-6-8(20-2)4-10(17)14(12)15(13)18/h3-6,16-17H,1-2H3
InChIKey AEUSBLWMURRGLG-UHFFFAOYSA-N
Formula C15H12O6
HBA 6
HBD 2
MW 288.25
Rotatable Bonds 2
TPSA 89.13
LogP 2.37
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 288.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Centaurium spicatum Gentianaceae Plantae 172074

Showing of synonyms

  • El-Shanawany MA, Mohamed GA, et al. (2011). A new xanthone from the roots of Centaurium spicatum. Phytochemistry Letters,2011,4,126-128. [View]
Pubchem: 13831944
Nmrshiftdb2: 70088944

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 288.25 g/mol

Antimicrobial
Antiprotozoal
Cytotoxicity

Absorption

Caco-2 (logPapp)
-4.84
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.660
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.77

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.200
Plasma Protein Binding
66.96
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.660
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.400
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.590
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.150
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.260
Rat (Acute)
2.130
Rat (Chronic Oral)
2.760
Fathead Minnow
4.740
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
425.660
Hydration Free Energy
-10.330
Log(D) at pH=7.4
2.900
Log(P)
3.41
Log S
-5.5
Log(Vapor Pressure)
-7.31
Melting Point
253.57
pKa Acid
8.96
pKa Basic
4.02
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9500
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9500
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9473
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9473
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9374
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9374
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9365
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9365
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9359
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9359
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9262
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9262
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9136
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9136
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8996
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8996
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8958
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8958
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8910
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8910
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8861
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8861
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8860
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8860
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8775
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8775
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8741
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8741
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8710
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8710
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8694
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8694
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8628
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8628
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8626
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8626
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8612
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8612
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.8601
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.8601
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8595
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8595
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8581
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8581
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8554
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8554
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8550
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8550
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8467
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8467
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8451
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8451
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8444
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8444
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8422
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8422
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8370
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8370
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8370
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8370
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8362
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8362
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8311
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8311
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8293
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8293
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8255
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8255
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8239
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8239
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8115
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8115
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8098
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8098
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8084
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8084
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.8068
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.8068
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8020
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8020
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7998
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7998
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7995
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7995
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7976
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7976
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7971
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7971
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7931
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7931
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7917
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7917
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7894
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7894
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7800
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7800
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7745
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7745
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7738
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7738
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7700
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7700
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7681
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7681
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7679
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7679
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7673
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7673
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7672
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7672
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7649
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7649
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7626
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7626
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7625
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7625
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7620
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7620
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7604
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7604
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7599
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7599
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7598
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7598
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7590
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7590
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7585
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7585
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7542
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7542
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7541
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7541
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7537
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7537
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7515
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7515
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7498
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7498
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7497
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7497
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7490
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7490
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7482
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7482
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7464
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7464
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 4 0.7460
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 4 0.7460
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7455
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7455
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7435
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7435
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7429
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7429
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7421
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7421
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7415
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7415
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7413
Reaction center protein L chain P0C0Y8 RCEL_RHOSH Rhodobacter sphaeroides 3 0.7413
Reaction center protein L chain P0C0Y8 RCEL_RHOSH Rhodobacter sphaeroides 3 0.7413
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7413
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7401
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7401
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7397
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7397
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7396
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7396
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7387
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7387
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7381
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7381
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7375
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7375
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7372
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7372
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7366
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7366
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7320
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7320
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7313
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7313
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7298
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7298
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7296
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7296
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7294
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7294
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7286
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7286
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7277
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7277
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7276
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7276
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7275
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7275
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7272
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7272
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7268
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7268
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7262
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7262
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7252
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7252
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7244
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7244
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7242
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7242
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7237
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7237
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7236
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7236
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7225
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7225
Orotidine 5'-phosphate decarboxylase Q9KQT7 PYRF_VIBCH Vibrio cholerae serotype O1 4 0.7187
Orotidine 5'-phosphate decarboxylase Q9KQT7 PYRF_VIBCH Vibrio cholerae serotype O1 4 0.7187
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7186
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7186
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7170
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7170
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7156
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7156
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7155
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7155
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7142
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7142
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7136
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7136
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7118
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7118
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7111
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7111
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7105
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7105
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7103
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7103
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7089
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7089
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7085
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7085
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7085
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7085
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7067
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7067
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7066
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7066
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7063
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7063
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7062
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7062
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7049
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7049
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7045
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7045
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7037
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7037
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7036
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7036
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7035
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7035
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7034
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7034
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7027
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7027
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7023
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7023
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7021
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7021
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7002
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7002

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